Effect of lipophilic nutrients on diabetic eye diseases

A diabetic and diabetic technology, applied in the field of the effect of lipophilic nutrients on diabetic eye disease, can solve the problem of difficult delivery of therapeutic/preventive drugs

Inactive Publication Date: 2016-11-23
奥米尼埃克蒂夫健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0028] From the above, it is clear that there is a need for a technology that can overcome difficulties in therapeutic / prophylactic drug delivery (even at reduced dose levels) for diabetic ocular complications

Method used

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  • Effect of lipophilic nutrients on diabetic eye diseases
  • Effect of lipophilic nutrients on diabetic eye diseases
  • Effect of lipophilic nutrients on diabetic eye diseases

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0145] In some embodiments, a method for preparing a novel water-soluble composition with enhanced bioavailability comprises:

[0146] (i) dissolving curcumin, at least one antioxidant, hydrophilic carrier and fat in a solvent to form a homogeneous mixture;

[0147] (ii) heating the obtained mixture at a temperature range of 25°C-60°C for 4-8 hours to obtain a dry-wet mixture;

[0148] (iii) removing the solvent by evaporation to form a dry mixture; and

[0149] (iv) Grinding the dry blend to obtain a fine powder.

[0150] The curcumin used in step (i) can be commercially available, and its content range is 85-96%. It can also be curcumin-rich turmeric extract. The amount of curcumin added may be sufficient to make the water-soluble curcumin contain 1-55% curcumin.

[0151] The antioxidant used in step (i) may be selected from: natural tocopherol, ascorbyl palmitate, rosemary extract, epigallocatechin, catechin, ascorbic acid and mixtures thereof. The amount of antioxidan...

Embodiment 1

[0163] UltraSol Lutemax2020 TM and UltraSol CurcuWin TM Effect on diabetic cataract

[0164] experimental design

[0165]Male Wistar strain (WNIN) rats (2 months old; mean BW 213±14 g) were obtained from the National Center for Laboratory Animal Science, National Institute of Nutrition, Hyderabad, India. Animals were maintained on NCLAS, NIN, and acclimatized in the laboratory for 2 weeks. Overnight fasted animals were injected intraperitoneally with a single dose of STZ (30 mg / kg) in 0.1 M citrate buffer, pH 4.5. Another group of rats received vehicle only as a control (Group I; n=12). Fasting blood glucose levels were measured 72 hours after STZ injection. Animals with blood glucose levels >150 mg / dL were considered diabetic and they were divided into 5 groups (Groups II-VI). A control group of rats (n=6) was fed with 0.01% soluble curcumin (group VII) and 0.5% soluble lutein (group VIII) alone.

[0166] All animals were housed individually and maintained on their res...

Embodiment 2

[0206] UltraSol Lutemax2020 TM -Impact on diabetic retinopathy (by genetic nutrition approach)

[0207] Determination of soluble lutein by genetic nutrition method (UltraSol Lutemax2020 TM ) beneficial effect on the retina of diabetic rats and compared this effect with common lutein

[0208] Methodology

[0209] Animal model: Streptozotocin (STZ) diabetic rat model is one of the most commonly used models of human diabetes. It is known to mimic a variety of acute and some chronic complications observed in human diabetes. The strength of this model is that it is highly reproducible, and the timelines for the development of various complications are well established and reproducible. Given the similarity of certain structural, functional, and biochemical abnormalities in the human disease, it is considered an appropriate model to evaluate the mechanisms of diabetes and its potential treatments.

[0210] Experimental design: Male Wistar-NIN (WNIN) rats (2 months old; mean B...

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Abstract

Compositions containing molecular dispersions of lipophilic nutrients and methods thereof are provided for delaying the development and maturation of eye related complications of diabetes by administering a composition containing lipophilic nutrients. More particularly, methods relate to delaying the development and maturation of eye related complications of diabetes by administering a composition containing lutein and its isomers, lutein ester, zeaxanthin isomers, turmeric extract, curcumin or curcuminoids, derived from plant extract / oleoresin containing xanthophylls / xanthophylls esters which are safe for human consumption and are particularly useful as dietary supplements for nutrition and health promoting benefits.

Description

field of invention [0001] The present invention relates to a method of delaying the development and formation of diabetic eye-related complications by administering a composition comprising lipophilic nutrients. More specifically, the present invention relates to a method for delaying the development and formation of diabetic eye-related complications by administering a composition comprising lutein and its isomers, lutein esters, zeaxanthin One or a combination of isomers, turmeric extracts, curcumin or curcuminoids derived from plant extracts / oleoresins containing luteolin / lutein esters, which are safe for human consumption and used as dietary Supplements are especially useful for nutritional and health-promoting benefits. Background of the invention [0002] The eye, protected by the bony orbit, is the most important and complex organ of the human body. It is divided into anterior segment, which is composed of cornea, iris, lens, ciliary body and sclera. The posterior ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K36/9066A61K31/09A61K31/047A61K9/00A61K47/44A61K47/38A61K47/36A61K47/32A61K47/26A61K47/22A61K47/20A61K47/10A23L33/105A61P27/12A61P9/10A61P27/02A61P3/10
CPCA61K9/0053A61K31/047A61K31/09A61K36/9066A61K36/9068A61K47/10A61K47/20A61K47/22A61K47/26A61K47/32A61K47/36A61K47/38A61K47/44A61K2300/00A23L33/105A61K47/00A61K31/12A61P27/02A61P27/12A61P9/10A61P3/10A23V2200/328A23V2002/00A61K9/0056
Inventor J·德什潘德S·吉亚寇迪
Owner 奥米尼埃克蒂夫健康科技有限公司
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