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Tilmicosin inclusion compound chitosan temperature-sensitive gel and preparation method thereof

A technology of tilmicosin and temperature-sensitive gel, which is applied in the field of tilmicosin inclusion compound chitosan temperature-sensitive gel and its preparation, can solve problems such as poor taste, affecting animal feed intake, and failure to achieve therapeutic effects. Achieve good needle penetration effect

Inactive Publication Date: 2016-12-07
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the bitter taste and poor taste of tilmicosin, it affects the feed intake of animals and fails to achieve the desired therapeutic effect

Method used

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  • Tilmicosin inclusion compound chitosan temperature-sensitive gel and preparation method thereof
  • Tilmicosin inclusion compound chitosan temperature-sensitive gel and preparation method thereof
  • Tilmicosin inclusion compound chitosan temperature-sensitive gel and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0027] A kind of tilmicosin inclusion compound chitosan thermosensitive gel and preparation method thereof:

[0028] (1) Dissolve chitosan with a deacetylation degree of 85% in 0.1mol / L hydrochloric acid, stir until completely dissolved to obtain a 10 mg / mL chitosan solution, and dissolve sodium glycerophosphate in deionized water to obtain 0.2 g / mL sodium glycerophosphate solution, add the sodium glycerophosphate solution dropwise to the chitosan solution and mix, adjust the pH of the mixed solution to 7.1-7.4, then stir the mixed solution evenly at 4°C to obtain a chitosan thermosensitive gel;

[0029] (2) Weigh HP-β-CD in a mortar, weigh water to dissolve it according to the ratio of water to HP-β-CD mass ratio of 2:1, and dissolve it according to the mass ratio of HP-β-CD to tilmicosin 2:1. Take tilmicosin in a mortar in a ratio of :1, mix and grind for 30 minutes at a temperature of 20° C. to obtain a white powder, and pass through an 80-mesh sieve to obtain the inclusion...

Embodiment 2

[0032] A kind of tilmicosin inclusion compound chitosan thermosensitive gel and preparation method thereof:

[0033] (1) Dissolve chitosan with a deacetylation degree of 85% in 0.1mol / L hydrochloric acid, stir until completely dissolved to obtain a 15 mg / mL chitosan solution, and dissolve sodium glycerophosphate in deionized water to obtain 0.6 g / mL sodium glycerophosphate solution, add the sodium glycerophosphate solution dropwise to the chitosan solution and mix, adjust the pH of the mixed solution to 7.1-7.4, then stir the mixed solution evenly at 4°C to obtain a chitosan thermosensitive gel;

[0034] (2) Weigh HP-β-CD in a mortar, weigh water to dissolve it according to the ratio of water to HP-β-CD mass ratio of 3:1, and dissolve it according to the mass ratio of HP-β-CD to tilmicosin 2 Take tilmicosin in a mortar in a ratio of :1, mix and grind for 30 minutes at a temperature of 20° C. to obtain a white powder, and pass through an 80-mesh sieve to obtain the inclusion co...

Embodiment 3

[0037] A kind of tilmicosin inclusion compound chitosan thermosensitive gel and preparation method thereof:

[0038] (1) Take by weighing a deacetylation degree of 85% chitosan and dissolve it in 0.1mol / L hydrochloric acid, fully stir until completely dissolved to obtain a 20 mg / mL chitosan solution, and dissolve sodium glycerophosphate in deionized water to obtain 1.0 g / mL sodium glycerophosphate solution, add the sodium glycerophosphate solution dropwise to the chitosan solution and mix, adjust the pH of the mixed solution to 7.1-7.4, then stir the mixed solution evenly at 4°C to obtain a chitosan thermosensitive gel;

[0039] (2) Weigh HP-β-CD in a mortar, weigh water to dissolve it according to the ratio of water to HP-β-CD mass ratio of 2:1, and dissolve it according to the mass ratio of HP-β-CD to tilmicosin 2:1. Take tilmicosin in a mortar in a ratio of :1, mix and grind for 30 minutes at a temperature of 20° C. to obtain a white powder, and pass through an 80-mesh siev...

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Abstract

The invention belongs to the field of chemical synthesis, and in particular relates to a tilmicosin inclusion complex chitosan temperature-sensitive gel and a preparation method thereof. The preparation method comprises the following steps: dissolving chitosan in 0.1mol / L hydrochloric acid by weighing and fully stirring until Dissolve the sodium glycerophosphate in deionized water, add the sodium glycerophosphate solution dropwise into the chitosan solution, adjust the pH value of the mixed solution, and stir the resulting mixed solution at 4°C to obtain the chitosan thermosensitive gel, which is called Take a tilmicosin inclusion compound in a conical flask, add an appropriate amount of chitosan thermosensitive gel into the conical flask, and stir evenly with a magnetic stirrer at room temperature to obtain a tilmicosin inclusion complex thermosensitive gel. The invention has the advantages of low toxicity, high bioavailability and low injection irritation.

Description

technical field [0001] The invention belongs to the field of chemical synthesis, and in particular relates to a tilmicosin inclusion complex chitosan temperature-sensitive gel and a preparation method thereof. technical background [0002] Tilmicosion (Tilmicosion) is obtained by the American Eli Lilly (Elanco) Animal Health Company through the amination reaction of aldehyde groups after hydrolyzing and desugaring Tylosin in acid. The molecular formula is C46H80N2013, and the molecular weight is 869.15 present. Tilmicosin has a broad antibacterial spectrum, strong antibacterial activity, and a high concentration of the drug in the lungs. Clinical medication mainly treats respiratory diseases caused by Mycoplasma, Actinobacillus pleuropneumoniae, etc. However, tilmicosin is highly toxic, and injections are generally used in cattle. Therefore, most tilmicosin-related products on the market are oral medicines, which are mainly fed with mixing materials and administered with ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K31/706A61K9/06A61P31/04A61P11/00
CPCA61K31/706A61K9/0019A61K9/06
Inventor 刘焕奇迟良邹明赵修龙毕可东
Owner QINGDAO AGRI UNIV
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