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Enteric hollow capsule and preparation method thereof

A hollow capsule, enteric-coated technology, applied in the directions of capsule delivery, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve the problems of affecting the sealing, affecting the efficacy, and breaking the gastric juice, so as to improve the sealing and slow down the water. The effect of reducing the loss of parts and improving the stability

Inactive Publication Date: 2017-01-04
JIANGSU LEFAN CAPSULE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the existing enteric-coated capsules are easy to lose water and become brittle when stored for a long time, which affects their sealing performance, and breaks in gastric juice, which affects the efficacy of the medicine.

Method used

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  • Enteric hollow capsule and preparation method thereof
  • Enteric hollow capsule and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Such as figure 1 As shown, an enteric hollow capsule includes a capsule shell 1 and an enteric coating 3, the enteric coating 3 is coated on the outer surface of the capsule shell 1, and the capsule shell 1 includes a capsule cap inserted into one body and the capsule body, the capsule cap and the capsule body are sealed by a layer of sealing film 4, and the sealing film 4 is arranged at the position where the opening end of the capsule cap and the capsule body are inserted. An isolation layer 2 is provided between the capsule shell 1 and the enteric coating 3 . The thickness of the isolation layer 2 is 7 μm, and the thickness of the enteric coating 3 is 10 μm.

[0025] A method for preparing an enteric-coated hollow capsule, comprising the following steps: using gelatin, cellulose, or pullulan to prepare a capsule liquid according to a known method, dipping the capsule liquid into a rubber mold to form a capsule shell, and The capsule shell includes a capsule cap and...

Embodiment 2

[0030] An enteric hollow capsule, comprising a capsule shell 1 and an enteric coating 3, the enteric coating 3 is coated on the outer surface of the capsule shell 1, and the capsule shell 1 includes a capsule cap and a capsule body inserted in one , the capsule cap and the capsule body are sealed by two layers of sealing film 4, and the sealing film 4 is arranged at the position where the opening end of the capsule cap and the capsule body are inserted. An isolation layer 2 is provided between the capsule shell 1 and the enteric coating 3 . The thickness of the isolation layer 2 is 10 μm, and the thickness of the enteric coating 3 is 15 μm.

[0031] A method for preparing an enteric-coated hollow capsule, comprising the following steps: using gelatin, cellulose, or pullulan to prepare a capsule liquid according to a known method, dipping the capsule liquid into a rubber mold to form a capsule shell, and The capsule shell includes a capsule cap and a capsule body; the capsule ...

Embodiment 3

[0036] An enteric hollow capsule, comprising a capsule shell 1 and an enteric coating 3, the enteric coating 3 is coated on the outer surface of the capsule shell 1, and the capsule shell 1 includes a capsule cap and a capsule body inserted in one , the capsule cap and the capsule body are sealed by two layers of sealing film 4, and the sealing film 4 is arranged at the position where the opening end of the capsule cap and the capsule body are inserted. An isolation layer 2 is provided between the capsule shell 1 and the enteric coating 3 . The thickness of the isolation layer 2 is 8 μm, and the thickness of the enteric coating 3 is 12 μm.

[0037] A method for preparing an enteric-coated hollow capsule, comprising the following steps: using gelatin, cellulose, or pullulan to prepare a capsule liquid according to a known method, dipping the capsule liquid into a rubber mold to form a capsule shell, and The capsule shell includes a capsule cap and a capsule body; then the caps...

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Abstract

The invention discloses an enteric hollow capsule and a preparation method thereof. The enteric hollow capsule comprises a capsule shell (1) and an enteric coating (3), the outer surface of the capsule shell (1) is wrapped by the enteric coating (3), the capsule shell (1) comprises a capsule cap and a capsule body which are inserted together, the capsule cap and the capsule body are sealed through a sealing film (4), and an isolating layer (2) is arranged between the capsule shell (1) and the enteric coating (3). The preparation method comprises the steps that a capsule liquid glue dipping mold is dipped with glue for forming, and the capsule shell is obtained; then the capsule shell is dipped with isolating liquid and dried; then the capsule shell is dipped with enteric coating liquid and dried; the capsule shell is placed on a sealing machine after demoulding, cutting and sleeving, and sealing liquid is added to the combination position of the capsule cap and the capsule body. The isolating layer for isolating water loss is additionally arranged between the enteric coating and the capsule shell to reduce loss of water of the capsule shell and improve the sealing performance of the enteric capsule.

Description

technical field [0001] The invention relates to the field of pharmaceutical dosage forms, in particular to an enteric-coated hollow capsule and a preparation method thereof. Background technique [0002] Enteric-coated capsules are capsules that can disintegrate and release drugs in the small intestine, and are generally used as drug packaging materials that damage the stomach. The existing enteric-coated capsules are mostly made of gelatin and enteric-coated materials, which can prevent the capsule from disintegrating in the acidic environment of the stomach, and can enter the small intestine with the emptying of the stomach, and collapse in the alkaline environment of the small intestine solution, release the drug. This makes the enteric-coated capsules need to have a good seal, otherwise in the environment of gastric juice, the corrosiveness of gastric juice will easily cause the capsule to disintegrate and fail. [0003] However, the existing enteric-coated capsules ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/38
CPCA61K9/4808A61K9/4866A61K9/4891
Inventor 方忠明王飞茅琦孔奇
Owner JIANGSU LEFAN CAPSULE
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