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Detection method of ginseng formula granules

A technology of formula granules and detection methods, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., and can solve the problems of inability to detect multiple active ingredients

Inactive Publication Date: 2017-01-04
JILIN AODONG GRP LIYUAN PHARM CO LTD
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Problems solved by technology

[0009] At present, the detection method of ginseng preparations is to detect one or a few components, but it is well known that the therapeutic effect of ginseng in TCM clinics does not come from a single active component, but the result of the joint action of multiple active components, so only one component is tested. One or a few ingredients, it is impossible to comprehensively detect the various active ingredients of ginseng

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  • Detection method of ginseng formula granules
  • Detection method of ginseng formula granules
  • Detection method of ginseng formula granules

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Embodiment Construction

[0021] Include the following steps:

[0022] (1) Chromatographic conditions and system suitability test Octadecylsilane bonded silica gel is used as filler; CAPCELL PAKMG, 4.6×250mm, 5μm; acetonitrile is used as mobile phase A, water is used as mobile phase B, as shown in the following table Gradient elution according to the regulations; the detection wavelength is 203nm, the number of theoretical plates should not be less than 6,000 based on the peak of ginsenoside Re, and should not be less than 200,000 based on the peak of ginsenoside Rd;

[0023]

[0024] (2) Preparation of reference substance solution Take appropriate amounts of ginsenoside Rg1 reference substance, ginsenoside Re reference substance and ginsenoside Rd reference substance, weigh them accurately, add methanol to make a mixed solution containing 0.2mg per 1ml, and get ready;

[0025] (3) Preparation of the test solution, accurately weighed 1 g of ginseng formula granules, accurately added 50 ml of methano...

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Abstract

The invention relates to a detection method of ginseng formula granules, and belongs to the field of modernization of Chinese traditional medicine. Octadecylsilane chemically bonded silica is used as a filler; the column is CAPCELL PAK MG, 4.6*250 mm, and 5 microns; acetonitrile is used as a mobile phase A, water is used as a mobile phase B, and gradient eluting is carried out; the detection wavelength is 203 nm, the number of theoretical plates is not lower than 6000 in terms of ginsenoside Re peaks and is not lower than 200000 in terms of ginsenoside Rd peaks; in the preparation of a reference substance solution and a test solution, 5 microliters of the reference substance solution and 5 microliters of the test solution are adsorbed precisely respectively and then are injected into a liquid chromatograph, collection lasts for 120 minutes, and a chromatogram map is recorded. According to the detection method, the ginseng formula granules are qualitatively detected relatively comprehensively, and the method is a qualitative ginseng formula granule detection method with relatively high specificity.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine modernization, and in particular relates to a method for detecting characteristic spectrum of ginseng formula particles. Background technique [0002] Ginseng is the dried root and rhizome of Araliaceae Panax ginseng C.A.Mey. It is mostly excavated in autumn, washed and sun-dried or dried. The cultivated ginseng is commonly called "garden ginseng"; the one that grows naturally in the wild state of the forest is called "forest ginseng", and is commonly called "seed sea". It mainly contains ginsenosides, the content of total saponins in various ginseng is usually 2% to 12%, and the content of total saponins in branch roots and fibrous roots is higher than that in tap roots; among them, it is mainly damane-type tetracyclic triterpene saponins, such as ginsenosides R a1 , R a2 , R a3 , R b1 , R b2 , R b3 , R c , R d , R e , R f Wait. Hydrolysis can get ginsengdiol or panaxatrio...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 刘同彦陈志国李苹杨献玲
Owner JILIN AODONG GRP LIYUAN PHARM CO LTD
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