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Detection method for schisandra chinensis formula granule

A technology of formula granules and detection methods, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., and can solve the problems of inability to detect multiple active ingredients

Inactive Publication Date: 2017-01-04
JILIN AODONG GRP LIYUAN PHARM CO LTD
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Problems solved by technology

[0007] At present, the detection method of Schisandra preparations is to detect one or a few ingredients, but it is well known that the therapeutic effect of Schisandra in Chinese medicine does not come from a single active ingredient, but the result of the joint action of multiple active ingredients, so only one One or a few ingredients, it is impossible to comprehensively detect the various active ingredients of Schisandra chinensis

Method used

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  • Detection method for schisandra chinensis formula granule
  • Detection method for schisandra chinensis formula granule
  • Detection method for schisandra chinensis formula granule

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Embodiment Construction

[0019] Include the following steps:

[0020] (1) Chromatographic conditions and system suitability test with Diamonsil C 18 , 4.6×250mm, 5μm as chromatographic column; acetonitrile as mobile phase A, water as mobile phase B, gradient elution as shown in the table below; flow rate: 1.0ml / min; column temperature: 30°C; detection wavelength is 220nm, theoretical The number of plates should not be less than 5000 based on the peak of schisandrin;

[0021]

[0022] (2) Preparation of reference solution: Take the appropriate amount of schisandrin A reference substance, schisandrin A reference substance, and schisandrin B reference substance, accurately weigh them, and add methanol to make each 1ml contain 0.1 mg of schisandrin A and 0.03 mg of schisandrin A. , the mixed solution of Schisandrin B 0.06mg, shake well, and get it.

[0023] (3) Preparation of the test solution Take Schisandra chinensis formula granules and grind finely, accurately weigh 0.25g, put in a stoppered Erle...

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Abstract

The invention relates to a detection method for a schisandra chinensis formula granule, belonging to the field of modernization of Chinese traditional medicines. The method comprises the following steps: taking Diamonsil C18, being 4.6*250mm and 5 microns, as a chromatographic column; taking acetonitrile as a mobile phase A and water as a mobile phase B and performing gradient eluting; keeping the flow rate to be 1.0ml / min and the column temperature to be 30 DEG C, wherein the detection wavelength is 220nm and the number of a theoretical plate shall be not less than 5000 on the basis of deoxyschizandrin peak calculation; preparing a reference substance solution and a test solution; respectively accurately sucking 10mul reference substance solution and 10mul test solution; injecting intoliquid chromatograph and determining. The detection method provided by the invention is used for comprehensively qualitatively detecting the schisandra chinensis formula granule and is a qualitative detection method for the schisandra chinensis formula granule with relatively high specificity.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine modernization, and in particular relates to a method for detecting characteristic spectrum of ginseng formula particles. Background technique [0002] Schisandra chinensis (Turcz.) Baill. is the dry and mature fruit of Magnoliaceae Schisandra chinensis (Turcz.) Baill. It is a commonly used Chinese medicinal material, mainly produced in Liaoning, Jilin, Heilongjiang, Hebei and other places. It has the effects of astringing the lungs, nourishing the kidneys, promoting body fluid, absorbing sweat, and astringent essence. It is used to treat dyspnea and cough due to lung deficiency, dry mouth and thirst, spontaneous sweating, night sweats, fatigue and emaciation, nocturnal nocturnal emission, chronic diarrhea and dysentery. [0003] Modern studies have shown that Schisandra contains lignans, volatile oils, organic acids, vitamins, triterpenes, sesquiterpenes and polysaccharides and other c...

Claims

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Application Information

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IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 刘同彦陈志国李苹唐秋竹
Owner JILIN AODONG GRP LIYUAN PHARM CO LTD
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