A method for preparing polymer multilayer hydrogel drug sustained-release material

Abstract

The present invention is a method for preparing a polymer multilayer hydrogel drug sustained-release material, the main content of which is to pass the polyanionic polymer blend solution A and the polycation polymer blend solution B through a micro The multi-layer co-extrusion device performs multi-layer lamination, and seals it to make it slowly cross-link completely, realizes the structural customization of the drug-loaded polymer polyelectrolyte, and prepares a drug with flexible and controllable drug morphology distribution and drug release performance. The polymer hydrogel drug-loading system with alternating multi-layer structure can meet different drug release requirements. Compared with the traditional method of preparing polymer multilayer hydrogel drug sustained-release materials by layer-by-layer stacking, this method is a continuous production process, which is conducive to the improvement of production efficiency; the process is simple, and the product quality indicators between different batches It is stable, capable of large-scale industrial production, has a wide range of applications, and has broad industrialization and market prospects.

Description

technical field [0001] The invention relates to a preparation method of a polymer polyelectrolyte drug sustained-release material, and more specifically relates to a solution co-extrusion preparation method with adjustable structure, designable performance, continuous production and flexible drug release behavior. The invention discloses a multi-layered hydrogel drug slow-release material controlled release method, which belongs to the technical field of functional composite materials. Background technique [0002] Smart hydrogel is a kind of hydrogel that can respond to external stimuli, that is, when the external temperature, pH, light, magnetic field, ion concentration, electric field, pressure, biomolecules and other factors change, its morphological structure or properties also change. of change. This responsive property makes smart hydrogels play an important role in the preparation of environment-responsive drug sustained-release materials, and has attracted extensiv...

AI Technical Summary

Problems solved by technology

However, the traditional smart hydrogel drug sustained release system has many shortcomings: because it is generally a hydrophilic homogeneous system, the release behavior of the loaded drug is mostly nonlinear. The drug concentration is often low, and the therapeutic effect cannot be achieved; the preparation form is relatively single, and it is difficult to flexibly and effectively control the dosage and administration plan, and cannot meet the complex drug release requirements

[0005] Although the above studies can overcome the problem of single drug delivery scheme of traditional homogeneous hydrogel drug-loaded materials, the preparation method is too cumbersome, and the layer structure of drug-loaded materials needs to be constructed layer by layer. The process of drying or curing cross-linking is complex and time-consuming, which cannot meet the needs of industrial mass production; and due to the limitation of its preparation process, the thickness and layer structure of the material single layer cannot be flexibly adjusted, and it is difficult to meet different drug effects. Drug release requirements

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