A method for preparing polymer layered drug-loaded hydrogel with controllable drug distribution

Abstract

The present invention is a method for preparing polymer layered drug-loaded hydrogel, the main content of which is to co-extrude polyanionic polymer blend solution A and polycation polymer blend solution B through microlayer co-extrusion The device is laminated for multiple times, and it is sealed and placed to make it slowly cross-linked completely, so as to realize the structural customization of the drug-loaded polymer polyelectrolyte, and to prepare a flexible and controllable drug morphology distribution and drug release performance with alternating layers. Structured polymer hydrogel drug-loading system to meet different drug release requirements. Compared with the traditional method of preparing polymer layered drug-loaded hydrogel by layer-by-layer stacking, this method is a continuous production process, which is conducive to the improvement of production efficiency; the process is simple, and the product quality indicators between different batches are stable. Large-scale industrial production, wide application range, has broad industrialization and market prospects.

Description

technical field [0001] The present invention relates to a preparation method of a polymer layered drug-loaded hydrogel, and more specifically relates to a solution co-extrusion preparation preparation with controllable drug distribution, customizable material structure, designable performance, and continuous production. The invention relates to a polymer layered drug-loaded hydrogel method with flexible and variable drug release behavior, which belongs to the technical field of functional composite materials. Background technique [0002] Smart hydrogel is a kind of hydrogel that can respond to external stimuli, that is, when the external temperature, pH, light, magnetic field, ion concentration, electric field, pressure, biomolecules and other factors change, its morphological structure or properties also change. of change. This responsive property makes smart hydrogels play an important role in the preparation of environment-responsive drug sustained-release materials, an...

AI Technical Summary

Problems solved by technology

However, the traditional smart hydrogel drug sustained release system has many shortcomings: because it is generally a hydrophilic homogeneous system, the release behavior of the loaded drug is mostly nonlinear. The drug concentration is often low, and the therapeutic effect cannot be achieved; the preparation form is relatively single, and it is difficult to flexibly and effectively control the dosage and administration plan, and cannot meet the complex drug release requirements

[0005] Although the above studies can overcome the problem of single drug delivery scheme of traditional homogeneous hydrogel drug-loaded materials, the preparation method is too cumbersome, and the layer structure of drug-loaded materials needs to be constructed layer by layer. The process of drying or curing crosslinking is complex and time-consuming, which cannot meet the needs of large-scale industrial production; and due to the limitation of its preparation process, the thickness and layer structure of the material single layer cannot be flexibly adjusted, and it is difficult to meet the needs of different drugs. release demand

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