Preparation method of macromolecular multi-layered hydrogel drug sustained-release material

Abstract

The invention relates to a preparation method of a macromolecular multi-layered hydrogel drug sustained-release material. The preparation method mainly includes steps of performing laminar superimposition function on the proper mixture ratio and composition of polyanion macromolecular blended solution A and polycation macromolecular blended solution B through a micro-bedding co-extruding device, sealing and placing the solution A and solution B to make them crosslink slowly and completely to realize structuring of macromolecular polyelectrolyte loaded with drugs, and to prepare a macromolecular polyelectrolyte hydrogel drug loading system with flexible and controllable drug form distribution, flexible and controllable drug sustained-release performance and having alternative multilayered structure, so as to meet different drug sustained-release demands. Compared with the traditional method of preparing the macromolecular multi-layered hydrogel drug sustained-release material by superimposition layer by layer, the method is a continuous production method, and good for improving the production efficiency; the technique is simple, and product quality index between different batches is stable; the preparation can realize the large-scale industrial production, is wide in application scale and has wide industrial and market prospect.

Description

technical field [0001] The invention relates to a preparation method of a polymer polyelectrolyte drug sustained-release material, and more specifically relates to a solution co-extrusion preparation method with adjustable structure, designable performance, continuous production and flexible drug release behavior. The invention discloses a multi-layered hydrogel drug slow-release material controlled release method, which belongs to the technical field of functional composite materials. Background technique [0002] Smart hydrogel is a kind of hydrogel that can respond to external stimuli, that is, when the external temperature, pH, light, magnetic field, ion concentration, electric field, pressure, biomolecules and other factors change, its morphological structure or properties also change. of change. This responsive property makes smart hydrogels play an important role in the preparation of environment-responsive drug sustained-release materials, and has attracted extensiv...

AI Technical Summary

Problems solved by technology

However, the traditional smart hydrogel drug sustained release system has many shortcomings: because it is generally a hydrophilic homogeneous system, the release behavior of the loaded drug is mostly nonlinear. The drug concentration is often low, and the therapeutic effect cannot be achieved; the preparation form is relatively single, and it is difficult to flexibly and effectively control the dosage and administration plan, and cannot meet the complex drug release requirements

[0005] Although the above studies can overcome the problem of single drug delivery scheme of traditional homogeneous hydrogel drug-loaded materials, the preparation method is too cumbersome, and the layer structure of drug-loaded materials needs to be constructed layer by layer. The process of drying or curing cross-linking is complex and time-consuming, which cannot meet the needs of industrial mass production; and due to the limitation of its preparation process, the thickness and layer structure of the material single layer cannot be flexibly adjusted, and it is difficult to meet different drug effects. Drug release requirements

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