Preparation method of macromolecular laminar drug-loaded hydrogel with controllable drug distribution

Abstract

The invention discloses a preparation method of macromolecular laminar drug-loaded hydrogel with controllable drug distribution. The preparation method mainly includes steps of performing multiple times of laminar superimposition on polyanion macromolecular blended solution A with appropriate proportion and composition and polycation macromolecular blended solution B with appropriate proportion and composition through a microlayer co-extrusion device, and sealing and placing to allow the solution A and the solution B to crosslink slowly and completely to realize structuring of drug-loaded macromolecular polyelectrolyte so as to prepare a macromolecular hydrogel drug loading system with flexible and controllable drug form distribution and drug release performance and with an alternative multilayered structure to meet different drug release demands. Compared with a traditional method using layer-by-layer superposition to prepare the macromolecular laminar drug-loaded hydrogel, the method has the advantages that the method is a continuous production method and beneficial to the improving of production efficiency; the method is simple in process, the product quality indexes of different batches of produces are stable, and the method is capable of achieving large-scale industrial production, wide in application range and promising in industrialization and market prospect.

Description

technical field [0001] The present invention relates to a preparation method of a polymer layered drug-loaded hydrogel, and more specifically relates to a solution co-extrusion preparation preparation with controllable drug distribution, customizable material structure, designable performance, and continuous production. The invention relates to a polymer layered drug-loaded hydrogel method with flexible and variable drug release behavior, which belongs to the technical field of functional composite materials. Background technique [0002] Smart hydrogel is a kind of hydrogel that can respond to external stimuli, that is, when the external temperature, pH, light, magnetic field, ion concentration, electric field, pressure, biomolecules and other factors change, its morphological structure or properties also change. of change. This responsive property makes smart hydrogels play an important role in the preparation of environment-responsive drug sustained-release materials, an...

AI Technical Summary

Problems solved by technology

However, the traditional smart hydrogel drug sustained release system has many shortcomings: because it is generally a hydrophilic homogeneous system, the release behavior of the loaded drug is mostly nonlinear. The drug concentration is often low, and the therapeutic effect cannot be achieved; the preparation form is relatively single, and it is difficult to flexibly and effectively control the dosage and administration plan, and cannot meet the complex drug release requirements

[0005] Although the above studies can overcome the problem of single drug delivery scheme of traditional homogeneous hydrogel drug-loaded materials, the preparation method is too cumbersome, and the layer structure of drug-loaded materials needs to be constructed layer by layer. The process of drying or curing crosslinking is complex and time-consuming, which cannot meet the needs of large-scale industrial production; and due to the limitation of its preparation process, the thickness and layer structure of the material single layer cannot be flexibly adjusted, and it is difficult to meet the needs of different drugs. release demand

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