Preparation Technology of Compound Gentamicin Membrane

Abstract

The invention discloses a preparation process of a compound gentamicin film, made from, according to the formula, 750-770 parts of gentamicin sulfate, 2000-2100 parts of tetracaine hydrochloride, 50-60 parts of dexamethasone acetate, suitable polyvinyl alcohol (PVA), suitable chitosan, suitable sodium hydrogen sulfite, suitable steviosin, suitable tartaric acid, suitable indigo, and suitable of lemon yellow; the compound gentamicin film is prepared through the preparation of a drug film, the preparation of tetracaine hydrochloride hydroxypropyl-Beta-cyclodextrin inclusion, and the preparation of dissolution and mixing of other materials. By using the process of the invention, gel pharmaceutical value in the formula is made full use, effective ingredients of tetracaine hydrochloride tend to be more stable in the drug film and are better utilized, and the compound gentamicin film has low loss of effective ingredients and stable quality.

Description

technical field

[0001] The invention relates to a preparation process of a film (compound gentamicin film) for treating oral ulcer. Background technique

[0002] Compound gentamycin film: This variety was originally a product of Fuzhou Daoshan Pharmaceutical Factory. In 2003, the national approval number was changed uniformly. In 2004, Fuzhou Daoshan Pharmaceutical Factory was merged by our company, and this variety was also transferred to our company. In 2015 Obtained re-registration approval in June.

[0003] The compound gentamicin film is mainly made of more than 10 materials such as compound gentamicin, tetracaine hydrochloride, dexamethasone acetate and other auxiliary materials through inclusion, dissolution and film making. Among them, compound gentamicin is an aminoglycoside broad-spectrum antibiotic, which has antibacterial and bactericidal effects on a variety of Gram-negative bacteria and positive bacteria, and mainly plays an antibacterial and anti-inflammatory...

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