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Preparation Technology of Compound Gentamicin Membrane

A gentamicin film and preparation process technology, applied in the field of compound gentamicin film preparation process, can solve the problems of compound gentamycin film content instability, inability to fully and stably exert its effect, and easy degradation

Active Publication Date: 2018-12-14
FUZHOU JINXIANG CHINESE MEDICINE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The compound gentamicin film prepared by this method has shortcomings such as unstable content and easy degradation, so that the effect of this product cannot be fully and stably brought into play.

Method used

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  • Preparation Technology of Compound Gentamicin Membrane
  • Preparation Technology of Compound Gentamicin Membrane
  • Preparation Technology of Compound Gentamicin Membrane

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0069] 2.2 Preparation of mucilage: take enough purified water and add dilute hydrochloric acid to prepare a dilute hydrochloric acid aqueous solution with a pH value of 4. Dissolve the chitosan with an appropriate amount of dilute hydrochloric acid aqueous solution prepared above; set aside. Add polyvinyl alcohol to the prepared dilute hydrochloric acid aqueous solution, heat it in a water bath at 100°C to dissolve, add the dissolved chitosan and an appropriate amount of glycerin and stir evenly to obtain a glue solution.

[0070] 2.3 Verification of glue

[0071] 2.3.1 Orthogonal test method was used to optimize the glue formula after adding chitosan, and observe its film-forming properties.

[0072] 2.3.2 Prescription screening: On the basis of the single factor test, the amount of glycerin, chitosan and polyvinyl alcohol was selected as the investigation object, and the film-forming time was used as the investigation index, and L 9 (3 4 ) Orthogonal test, using intuitiv...

Embodiment 2

[0099] The second batch of experiments of embodiment 2:

[0100] (1) Weighing and ingredients

[0101] Receive 760 parts of gentamicin sulfate by weight, 2050 parts of tetracaine hydrochloride, 55 parts of dexamethasone acetate, appropriate amount of polyvinyl alcohol (PVA), appropriate amount of chitosan, appropriate amount of sodium bisulfite, appropriate amount of stevia, tartaric acid Appropriate amount, appropriate amount of beautiful blue, appropriate amount of lemon yellow. Check the product name, specification, batch number, and quantity, weigh out each material, and have a special person check it.

[0102] (2) Preparation of tetracaine hydrochloride hydroxypropyl-β-cyclodextrin inclusion compound

[0103] Take tetracaine hydrochloride and hydroxypropyl-β-cyclodextrin according to the weight ratio of 1:2, put the hydroxypropyl-β-cyclodextrin in a beaker, add a certain amount of purified water to make it saturated, and heat to dissolve and cooling; then add half the ...

Embodiment 3

[0116] The third batch of experiments of embodiment 3:

[0117] (1) Weighing and ingredients

[0118] Receive 770 parts of gentamicin sulfate by weight, 2100 parts of tetracaine hydrochloride, 60 parts of dexamethasone acetate, appropriate amount of polyvinyl alcohol (PVA), appropriate amount of chitosan, appropriate amount of sodium bisulfite, appropriate amount of stevia, tartaric acid Appropriate amount, appropriate amount of beautiful blue, appropriate amount of lemon yellow. Check the product name, specification, batch number, and quantity, weigh out each material, and have a special person check it.

[0119] (2) Preparation of tetracaine hydrochloride hydroxypropyl-β-cyclodextrin inclusion compound

[0120] Take tetracaine hydrochloride and hydroxypropyl-β-cyclodextrin according to the weight ratio of 1:2, put the hydroxypropyl-β-cyclodextrin in a beaker, add a certain amount of purified water to make it saturated, and heat to dissolve and cooling; then add half the a...

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Abstract

The invention discloses a preparation process of a compound gentamicin film, made from, according to the formula, 750-770 parts of gentamicin sulfate, 2000-2100 parts of tetracaine hydrochloride, 50-60 parts of dexamethasone acetate, suitable polyvinyl alcohol (PVA), suitable chitosan, suitable sodium hydrogen sulfite, suitable steviosin, suitable tartaric acid, suitable indigo, and suitable of lemon yellow; the compound gentamicin film is prepared through the preparation of a drug film, the preparation of tetracaine hydrochloride hydroxypropyl-Beta-cyclodextrin inclusion, and the preparation of dissolution and mixing of other materials. By using the process of the invention, gel pharmaceutical value in the formula is made full use, effective ingredients of tetracaine hydrochloride tend to be more stable in the drug film and are better utilized, and the compound gentamicin film has low loss of effective ingredients and stable quality.

Description

technical field [0001] The invention relates to a preparation process of a film (compound gentamicin film) for treating oral ulcer. Background technique [0002] Compound gentamycin film: This variety was originally a product of Fuzhou Daoshan Pharmaceutical Factory. In 2003, the national approval number was changed uniformly. In 2004, Fuzhou Daoshan Pharmaceutical Factory was merged by our company, and this variety was also transferred to our company. In 2015 Obtained re-registration approval in June. [0003] The compound gentamicin film is mainly made of more than 10 materials such as compound gentamicin, tetracaine hydrochloride, dexamethasone acetate and other auxiliary materials through inclusion, dissolution and film making. Among them, compound gentamicin is an aminoglycoside broad-spectrum antibiotic, which has antibacterial and bactericidal effects on a variety of Gram-negative bacteria and positive bacteria, and mainly plays an antibacterial and anti-inflammatory...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/722A61K31/7036A61K9/70A61K47/36A61K47/69A61P1/02A61P31/04A61K31/573A61K31/245
CPCA61K9/006A61K31/245A61K31/573A61K31/7036A61K31/722A61K47/36A61K2300/00
Inventor 连红郑玉华苏玉兰方梨英
Owner FUZHOU JINXIANG CHINESE MEDICINE PHARMA
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