A chitosan-based multilayer nanofiber membrane dressing and its preparation method and application
A nanofiber membrane and chitosan nanotechnology, applied in the direction of medical formulations, bandages, drug delivery, etc., can solve the problems that are not conducive to the wound healing process, cannot keep the wound moist, and unfavorable wound healing, etc., to promote wound healing, size Uniform controllable and adjustable composition effect
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[0068] The second aspect of the present invention provides a kind of preparation method of chitosan-based multilayer nanofiber membrane dressing, comprising:
[0069] (1) prepare chitosan nanofiber membrane by the method for electrospinning;
[0070] (2) Prepare chitosan solution and hydrophilic polymer solution respectively, and then adopt double-channel electrospinning to prepare chitosan-hydrophilic polymer composite membrane, chitosan-hydrophilic polymer composite film The membrane is a three-dimensional network structure formed by the interlaced arrangement of chitosan nanofibers and hydrophilic polymer nanofibers;
[0071] (3) placing the nano-bioactive glass in the hydrophilic polymer solution, stirring to obtain a mixed solution, and electrospinning the mixed solution to obtain a hydrophilic polymer fiber loaded with nano-bioactive glass. After the spinning is completed, A hydrophilic polymer film loaded with nano-bioactive glass was prepared on the chitosan-hydrophil...
Embodiment 1
[0116] to combine figure 1 Specifically describe a kind of preparation method of chitosan-based multilayer nanofiber membrane dressing, comprising:
[0117] (1) Preparation of chitosan nanofiber membrane
[0118] Weigh 0.7 g of chitosan (CS), and dissolve it in a mixed solution formed by 7 mL of TFA and 3 mL of DMC to obtain a CS solution, place the CS solution in a 37° C. 7% (w / v) CS solution, stored at 4°C for later use;
[0119] Use No. 7 syringe A to draw 4mL of 7% (w / v) CS solution, connect the positive pole of the high-voltage power supply to the needle tip, connect the negative pole to the receiving device, place the needle tube in the push pump, set the voltage to 14kV, and push The speed is 0.1mL / h, and the receiving distance is 12cm. Start the propulsion pump, and turn on the DC voltage infusion pump to push forward at a certain speed after there are droplets dripping from the needle. Combined with the action of the electric field force, the CS electrospinning liq...
Embodiment 2
[0132] A preparation method of chitosan-based multilayer nanofiber membrane dressing, comprising:
[0133] (1) Preparation of chitosan nanofiber membrane
[0134] Weigh 0.5 g of chitosan (CS), and dissolve it in a mixed solution formed by 7 mL of TFA and 3 mL of DMC to prepare a CS solution. Place the CS solution in a 37° C. into a CS solution with a concentration of 5% (w / v), and store at 4°C for later use;
[0135] Use a No. 7 syringe to draw 4mL of 5% (w / v) CS solution, connect the positive pole of the high-voltage power supply to the needle tip, and connect the negative pole to the receiving device. Fix the needle tube on the propulsion pump, set the voltage to 10kV, and the propulsion speed It is 0.05mL / h, and the receiving distance is 15cm. Start the propulsion pump, and turn on the DC voltage infusion pump to push forward at a certain speed after there are droplets dripping from the needle. Combined with the action of the electric field force, the CS electrospinning l...
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