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Polymethoxylated flavone, composition and application of polymethoxylated flavone preparation in preventing or treating diabetes

A technology of polymethoxylated flavonoids and diabetes, which is applied in the field of medicine, can solve the problems of neuropathy and diabetes without a substantial breakthrough in pathology, and achieve the improvement of impaired glucose tolerance, the improvement of fasting blood sugar levels, and the treatment and prevention of diabetes Effect

Active Publication Date: 2017-02-22
GUANGZHOU MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

At present, diet, exercise therapy, sulfonylureas, glinides, biguanides, thiazolidinediones, α-glucoside inhibitors, insulin, etc. are mainly used in the treatment of type II diabetes. There is no substantive breakthrough. While taking western medicine for a long time, patients continue to have complications such as cardiovascular disease, kidney disease, and neuropathy.

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  • Polymethoxylated flavone, composition and application of polymethoxylated flavone preparation in preventing or treating diabetes
  • Polymethoxylated flavone, composition and application of polymethoxylated flavone preparation in preventing or treating diabetes
  • Polymethoxylated flavone, composition and application of polymethoxylated flavone preparation in preventing or treating diabetes

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Embodiment Construction

[0020] The technical solutions of the present invention will be described in detail below in conjunction with the accompanying drawings and embodiments.

[0021] experimental method:

[0022] 1. Establishment of animal models

[0023] Take 60 C57BL / 6 male mice, weighing 18-20 g, aged 6 weeks. After one week of adaptation, the mice were randomly divided into: normal chow diet (NCD), high fat diet (HFD), 3,5,6,7,8,3',4'-heptagram Low-dose oxyflavone group (HMF-L) and high-dose 3,5,6,7,8,3',4'-heptamethoxyflavone group (HMF-H), all groups except normal feed group Eat a high-fat diet. HFD feed formula is: 1.25% cholesterol, 20% lard, 5% sucrose, 0.5% cholic acid, vitamins adjusted to normal levels. Modeling began to administer drugs, and the experimental period was 6 weeks. NCD and HFD were given the same volume of 0.5% CMC-Na solution.

[0024] 2. Dosage and administration method: In the HFD induction experiment, mice were administered by intragastric administration. Modeli...

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Abstract

The invention discloses a polymethoxylated flavone, a composition and application of the polymethoxylated flavone preparation in preventing or treating diabetes. The active component of the medicine for preventing and treating diabetes comprises a polymethoxylated flavone and a pharmaceutically acceptable carrier or excipient which are made into a pharmaceutically acceptable preparation formulation, wherein the polymethoxylated flavone is 3,5,6,7,8,3',4'-heptamethoxyflavone. The invention proves that the 3,5,6,7,8,3',4'-heptamethoxyflavone can effectively improve the fasting blood glucose level increase of the high-fat-diet-induced diabetes model and improve the Type II diabetes mainly characterized in impaired glucose tolerance reduction and insulin sensitivity reduction, and thus, can be used for treating and preventing diabetes.

Description

technical field [0001] The invention belongs to the field of medicine and relates to new uses of natural products, in particular to the use of polymethoxylated flavones, compositions and preparations thereof for preventing or treating diabetes. Background technique [0002] Diabetes mellitus is an endocrine and metabolic disease characterized by hyperglycemia due to defective insulin secretion (type I diabetes) or insulin resistance (type II diabetes), and has now become the third major threat to human health after cardiovascular disease and cancer. disease. According to a report released by the International Diabetes Federation (IDF) in 2015, about 415 million adults worldwide suffer from diabetes, and about 5 million people are expected to die from diabetes. At present, diet, exercise therapy, sulfonylureas, glinides, biguanides, thiazolidinediones, α-glucoside inhibitors, insulin, etc. are mainly used in the treatment of type II diabetes. There is no substantive breakth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K31/7048A61P3/10
CPCA61K31/352A61K31/7048A61K2300/00
Inventor 郑国栋刘鄂湖韦敏燕
Owner GUANGZHOU MEDICAL UNIV
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