Application of metformin used for preparation of medicine for treating and/or preventing squamous cell carcinoma of head and neck and pharmaceutical composition
A technology of metformin and its composition, which is applied in the field of preparation of drugs for the treatment and/or prevention of head and neck squamous cell carcinoma and the field of pharmaceutical composition, and can solve problems such as unclear molecular mechanism
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Embodiment 1
[0036] 1. Hypoglycemia promotes anoikis in Metformin-induced head and neck squamous cell carcinoma FaDu cells.
[0037] Figure 1-Figure 4 The dosage of metformin in the drug was 20 mmol / L.
[0038] The process of anoikis in head and neck squamous cell carcinoma FaDu cells is as follows: figure 1 As shown, adherent cells undergo apoptosis after detaching from their growth site.
[0039] figure 2 It was obtained by adding 20 mmol / L metformin to treat FaDu cells for 24 hours under the conditions of blood glucose concentration of 4.5 mg / mL and blood glucose concentration of 1.0 mg / mL, and counting the number of adherent cells by hemocytometer. like figure 2 As shown, when the blood glucose concentration was 4.5 mg / mL, metformin had no effect on FaDu cells of head and neck squamous cell carcinoma, and when the blood glucose concentration was 1.0 mg / mL, the number of adherent cells of FaDu cells of head and neck squamous cell carcinoma decreased significantly, indicating that...
Embodiment 2
[0047] Based on the use of metformin of the present invention in the preparation of drugs for the treatment and / or prevention of head and neck squamous cell carcinoma, the present invention also provides a pharmaceutical composition comprising metformin as an active ingredient, an active ingredient of a hypoglycemic drug, one or more pharmaceutical acceptable excipients or excipients.
[0048] The active ingredients of the hypoglycemic drugs include insulin and its analogs, sulfonylurea secretagogues, metformin, α-glucosidase inhibitors, thiazolidinedione derivatives sensitizers, fennelic acid derivatives Any one or more of the active ingredients in secretagogues, GLP-1 receptor agonists, DDP-4 enzyme inhibitors, and Chinese patent medicines. The therapeutic effect of metformin is achieved by creating a glucose-starved environment through the active ingredients of hypoglycemic drugs. Metformin and hypoglycemic drug active ingredients are selected according to conventional dos...
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