Composition for preventing livestock skin diseases and preparation method thereof
A composition and technology for skin diseases, applied in the directions of skin diseases, drug combinations, active ingredients of heterocyclic compounds, etc., can solve problems such as increasing the risk of skin diseases, imbalance of microbial diversity, and reducing production performance, and improve animal skin resistance. Weak strength, improve skin resistance, prevent skin diseases
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Embodiment 1
[0033] A traditional Chinese medicine compound capsule for preventing livestock skin diseases, comprising: 3 parts by weight of astragalus, 4 parts by weight of Angelica dahurica, 4 parts by weight of hibiscus bark, 3 parts by weight of angelica, 2 parts by weight of wolfberry, 2 parts by weight of tribulus terrestris, and 2 parts by weight of vitamin B parts, EGF 2 parts by weight.
[0034] Its specific preparation method is as follows:
[0035] In the first step, take Tribulus terrestris, Angelica dahurica, hibiscus bark, and angelica plus 8 times the amount of water, soak for 0.5 hours, extract volatile oil for 8 hours, collect volatile oil, volatile oil and β-cyclodextrin in a weight ratio of 1:10 inclusion, 40 Dry at ℃, and store the extracted medicinal solution in another container;
[0036] In the second step, decoct the dregs obtained in the first step with 10 times the weight of the mixture of wolfberry and astragalus, and decoct them for 3 times, each time for 2 hou...
Embodiment 2
[0039]A traditional Chinese medicine compound injection for preventing livestock skin diseases, comprising: 3 parts by weight of astragalus, 4 parts by weight of Angelica dahurica, 4 parts by weight of hibiscus bark, 3 parts by weight of angelica, 2 parts by weight of wolfberry, 2 parts by weight of tribulus terrestris, and 2 parts by weight of vitamin B , EGF 2 parts by weight.
[0040] Its specific preparation method is as follows:
[0041] In the first step, take Tribulus terrestris, Angelica dahurica, hibiscus bark, and angelica plus 8 times the amount of water, soak for 0.5 hours, extract volatile oil for 8 hours, collect volatile oil, volatile oil and β-cyclodextrin in a weight ratio of 1:10 inclusion, 40 Dry at ℃, and store the extracted medicinal solution in another container;
[0042] In the second step, decoct the dregs obtained in the first step with 10 times the weight of the mixture of wolfberry and astragalus, and decoct them for 3 times, each time for 2 hours. ...
Embodiment 3
[0045] 1. Long-term toxicity test process
[0046] Use Wistar rats (provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.) to set the experimental drug to three doses of high, medium and low, which are capsules 8g / kg, 4g / kg, and 2g of the formula in Example 1, respectively. / kg. Another control group was set up, and the effects on various physiological and biochemical indexes of rats were observed after continuous intragastric administration for 90 days and 180 days and part of the animals were stopped for 10 days. The experimental results show that: continuous oral administration of different doses to rats for 180 days has no effect on the food intake and weight growth of the rats. No significant toxic effects were found on liver and kidney function. There was no obvious effect on blood routine, blood biochemistry, urine biochemistry and bone marrow slices, and there was no significant difference between each group and the control group.
[0047] 2. Ac...
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