Expansion of lymphocytes with a cytokine composition for active cellular immunotherapy
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A technology of lymphocytes and cytokines, applied in the field of cytokine composition and clinically relevant lymphocytes
Active Publication Date: 2017-04-19
保利比奥斯博特有限责任公司
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Only about 15 to 20% of patients have resectable tumors, so the disease has the potential to be cured
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Embodiment 1
[0215] Example 1 - Lymphocyte Expansion Protocol Using Peripheral Blood Mononuclear Cells
[0238] Mixed human AB serum (Innoative Research, IPLA-SerAB-13458)
[0239] Fetal bovine ser...
Embodiment 2
[0248] Example 2 Lymphocyte Expansion Protocol Using Peripheral Blood Mononuclear Cells
[0249] The procedure of Example 2 is the same as that of Example 1, except that the donor is a patient receiving NY-ESO-1 vaccination.
Embodiment 3
[0250] Example 3 - Lymphocyte Expansion Protocol Using Peripheral Blood Mononuclear Cells
[0251] Example 3 is the same as Example 1, except that the donor is a patient whose tumor already expresses TAA NY-ESO-1.
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Abstract
The present invention relates to a composition for expanding lymphocytes comprising at least two types of cytokines selected from interleukin 2 (IL-2), interleukin 15 (IL-15) and interleukin 21 (IL-21). It further relates to a Method of preparing a population of clinically relevant lymphocytes, comprising the steps of: obtaining a body sample from a mammal in particular a tissue sample or body liquid sample, comprising at least one lymphocyte and optionally separating the cells in the body sample, culturing the body sample in-vitroto expand and / or stimulate lymphocytes in the sample wherein the culturing comprises using IL-2, IL-15 and / or IL-21, and optionally determining the presence of clinically relevant lymphocyte in the cultured sample.The present invention also relates to an immunotherapy and the population of clinically relevant lymphocytes.
Description
technical field [0001] The present invention relates to active cellular immunotherapy comprising methods of producing clinically relevant lymphocyte populations using predetermined cytokine compositions. The invention also relates to cytokine compositions and the resulting clinically relevant lymphocytes. Background technique [0002] Cancer remains one of the most common causes of death in developed countries. For example, it is the second most common cause of death in the United States and Germany, with 560,000 (2009) and 218,000 (2010) deaths, respectively. Despite improvements in the ability to detect and treat this range of diseases, survival rates for many cancers remain low. [0003] Among cancer diseases, pancreatic cancer is the fourth leading cause of cancer death in the United States and Sweden, and shows no sign of improvement. By the time pancreatic cancer is diagnosed, most patients with locally advanced cancer or metastatic disease are not cured and are per...
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