Substituted muramyl dipeptide compound and preparation method and applications thereof

A compound and composition technology, applied in the direction of dipeptide components, medical preparations containing active ingredients, peptides, etc., can solve the problems of unclear relationship between tumors and the need for further research on NOD1/2 receptors
CN106589055AActive Publication Date: 2017-04-26TSINGHUA UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
TSINGHUA UNIV
Publication Date
2017-04-26

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Abstract

The invention discloses a substituted muramyl dipeptide compound and a preparation method and applications thereof, and further discloses a pharmaceutical composition of the compound and applications of the pharmaceutical composition. The substituted muramyl dipeptide compound can antagonize human derived or mouse derived immune cell NOD1 and / or NOD2 mediated inflammation NF-[kappa]B and MAPKs signal transduction pathway and inhibit the growth and metastasis of tumors.
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Description

technical field

[0001] The present invention relates to the field of medicine, specifically, the present invention relates to substituted cytoacyl dipeptide compounds, their preparation method and use, and the use of antagonists in the preparation of medicines, more specifically, the present invention relates to paclitaxel or docetaxel and A compound obtained by linking its analogue with muramyl dipeptide through an ether bond, its preparation method and application, and the application of the antagonist comprising the above-mentioned compound in the preparation of medicaments. Background technique

[0002] Pattern recognition receptors NOD1 and NOD2 belong to the NOD-like receptors (NLRs) family, which is an important class of intrinsic pattern recognition receptors (pattern recognition receptors, PPRs) in the body, similar to Toll-like receptors (TLRs), by recognizing exogenous Pathogen-associated molecular pattern (pathogen associated molecular pattern, PAMP) or endogenou...

Claims

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