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Antipyretic-analgesic externally-used patch prepared from high polymer material

A polymer material, antipyretic and analgesic technology, applied in non-active ingredients of polymer compounds, non-central analgesics, antipyretics, etc., can solve problems such as kidney damage, achieve ideal effects, long drug action time, The effect of relieving symptoms of fever and soreness

Inactive Publication Date: 2017-05-10
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of these drugs currently on the market are oral solid preparations and oral solution preparations. However, with the clinical use of this product in large quantities, the gastrointestinal adverse reactions caused by oral administration are becoming more and more obvious. Many patients repeatedly Gastrointestinal discomfort of varying degrees occurred after administration, and it has also been reported that long-term oral administration of diclofenac can cause severe kidney damage

Method used

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  • Antipyretic-analgesic externally-used patch prepared from high polymer material
  • Antipyretic-analgesic externally-used patch prepared from high polymer material
  • Antipyretic-analgesic externally-used patch prepared from high polymer material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017]

[0018] The medicine preparation method of above-mentioned embodiment 1 is:

[0019] 1) 5% diclofenac, 5% gelatin, 1% Tween, 2% oleic acid, 2% menthol, 10% polyethylene glycol 300, 1% calcium carbonate were uniformly dispersed in 0.5 % sorbic acid and 22.5% glycerol to form phase A;

[0020] 2) Uniformly disperse 1% glutaraldehyde, 0.5% sorbic acid and 22.5% glycerin in the aqueous solution under heating and stirring conditions to form phase B;

[0021] 3) heating and stirring phase B in step 2 under a certain vacuum condition and uniformly dispersing in phase A to form a gel layer;

[0022] 4) Coating the gel layer obtained in step 3 on a non-woven fabric, covering it with a protective film, cutting it to a certain size, and refrigerating and solidifying to make a plaster preparation for external use containing diclofenac.

Embodiment 2

[0024]

Embodiment 3

[0026]

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PUM

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Abstract

The invention discloses antipyretic-analgesic externally-used patch prepared from a high polymer material, and a preparation method of the externally-used patch. The externally-used patch is characterized in that plaster takes diclofenac sodium as a main raw material, and is prepared by adding a certain amount of high polymer base glue, a surface active agent, a humectant, a cross-linking agent, an adhesive and a transdermal penetration enhancer. The plaster gives a good play to cooling and analgesic effects by means of transdermal drug delivery, has a remarkable effect for treating and relieving symptoms of fever and pain which are caused by various reasons, and enables a body not to have adverse effects.

Description

technical field [0001] The invention relates to a transdermal drug delivery preparation with antipyretic and analgesic properties, in particular to an external patch with antipyretic and analgesic properties prepared from polymer materials and a preparation method thereof. Background technique [0002] Diclofenac is an antipyretic and analgesic drug of non-steroidal anti-inflammatory drugs. After many years of clinical application, its antipyretic and analgesic effect has been recognized all over the world. Most of these drugs currently on the market are oral solid preparations and oral solution preparations. However, with the clinical use of this product in large quantities, the gastrointestinal adverse reactions caused by oral administration are becoming more and more obvious. Many patients repeatedly Gastrointestinal discomfort to varying degrees occurred after administration, and it has also been reported that long-term oral administration of diclofenac can cause severe ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/42A61K47/38A61K47/36A61K31/196A61P29/00
CPCA61K9/7023A61K9/0002A61K31/196A61K47/36A61K47/38A61K47/42
Inventor 樊李红王万吉
Owner WUHAN UNIV OF TECH
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