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Experimental method for medicine used for treating spinal cord injury (SCI)

An experimental method and technology of spinal cord injury, applied in the medical field, can solve the problems of lack of treatment methods and achieve the effect of effective treatment methods

Inactive Publication Date: 2017-05-17
连云港市东方医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the incidence of SCI presents a trend of increasing year by year, there is currently a lack of better treatment methods. The present invention transforms the basic research results into clinical treatment techniques, and provides an effective treatment method with less side effects for clinical practice. Promotion prospects

Method used

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  • Experimental method for medicine used for treating spinal cord injury (SCI)
  • Experimental method for medicine used for treating spinal cord injury (SCI)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0059] Example Acute spinal cord injury (SCI) rat model pre-test report:

[0060] Using a precision damage impactor (PinPoint TM PCI3000 Precision Cortical Impactor TM ) to make acute SCI rat model. After the acute SCI rat model was established, hydrogen-rich saline combined with methylprednisolone was used for drug intervention, and neurological function scores, HE staining and Prussian blue staining of tissue sections were performed at different time points to evaluate the course of acute SCI animals progress. The pre-test process and results are reported as follows:

[0061] (1. Purpose

[0062] An acute SCI rat model was made, drug intervention was performed with hydrogen-rich saline combined with methylprednisolone, and spinal cord function scores, HE staining and Prussian blue staining of tissue sections were performed at different time points to evaluate the effects of hydrogen-rich saline combined with methylprednisolone. Effects of prednisolone on hindlimb motor...

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Abstract

The invention discloses an experimental method for a medicine used for treating spinal cord injury (SCI). According to the method, SCI is treated by adopting hydrogen-rich normal saline and methylprednisolone; by comparing rat neural functional recovery, observing the morphological change of injured spinal nerve cells and the cell apoptosis condition, and exploring the effectiveness of the combined treatment, the therapeutic method of combination of hydrogen-rich normal saline and methylprednisolone is taken as a new method for treating SCI. MBI and ASIA score are recorded and analyzed; the clinic application effect of the therapeutic method is verified by adopting hydrogen-rich normal saline combined with methylprednisolone. According to the experimental method, evidence is acquired for the practical application of the therapeutic method by adopting hydrogen-rich normal saline combined with methylprednisolone in treating spinal cord injury. A more efficient therapeutic method is supplied for the spinal cord injury.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to an experimental method of medicine for treating spinal cord injury. Background technique [0002] With the development of the economic level of countries in the world, the incidence of spinal cord injury (SCI) is increasing year by year, and it leads to serious dysfunction of the limbs below the injured segment. While SCI brings serious physical and mental damage to the patients themselves, it also causes a huge economic burden to the whole society. Therefore, the prevention, treatment and rehabilitation of SCI have become a major topic in today's medical field. In the acute stage of SCI, in order to protect the incompletely injured spinal cord, it is necessary to take reasonable and effective neuroprotective measures in the early stage, so as to improve the neurological function of the injured spinal cord to a certain extent. [0003] At present, corticosteroids have been proven...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K67/02A61K49/00A61K33/00A61P25/28A61K31/573
CPCA01K67/02A61K31/573A61K33/00A61K49/0004A61K2300/00
Inventor 王文学张菁蒋娜娜刘岳鹏康新王建伟袁涛伏光辉刘宇梁彭霞林谢芳芳张爱娟龚来弟
Owner 连云港市东方医院
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