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A kind of pharmaceutical composition for preventing and treating neonatal jaundice, preparation method and application

A technology for neonatal jaundice and composition, applied in the field of pharmaceutical composition and preparation for preventing and treating neonatal jaundice, and the field of pharmaceutical composition for preventing and treating neonatal jaundice, which can solve the problem of lack of neonatal drug safety data and clinical experiment data, and potential safety hazards To achieve the effects of clear pharmacology, accelerated self-healing, and small side effects

Active Publication Date: 2020-02-11
HEFEI HUAFANG PHARMA SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In Chinese medicine, Yinzhihuang Oral Liquid is used to treat neonatal jaundice, but it is an adult drug, and there is no safety data and clinical experiment data for neonatal medication. If it is directly used for the treatment of neonatal jaundice, there will be a major safety hazard

Method used

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  • A kind of pharmaceutical composition for preventing and treating neonatal jaundice, preparation method and application
  • A kind of pharmaceutical composition for preventing and treating neonatal jaundice, preparation method and application
  • A kind of pharmaceutical composition for preventing and treating neonatal jaundice, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 Preparation of freeze-dried oral powder

[0035] Weigh 0.25g of geniposide, 4.0g of baicalin, 0.01g of p-hydroxyacetophenone, and 0.35g of chlorogenic acid, dissolve them in 800ml of purified water, adjust the pH value to 7.0 with 10% NaOH, add purified water to 1000ml, and filter , Packed into vials, 1ml per bottle. Move the vials to a vacuum freeze dryer for freeze drying. The temperature drops to -40°C within 1 hour, after 2 hours of heat preservation, the vacuum pump is turned on, the vacuum degree is maintained at 300 Pa, and the temperature is gradually raised to -5°C within 10 hours, the vacuum degree is reduced to 10 Pa, and the temperature is raised to +35°C after maintaining for 2 hours. After maintaining for 3 hours, the vacuum degree does not change, and then it is out of the box, capped, inspected, and packaged. Product moisture is not more than 1%.

Embodiment 2

[0036] Example 2 Preparation of freeze-dried oral powder

[0037] Weigh 0.25g of pregeniposide, 1.7g of baicalin, 0.005g of p-hydroxyacetophenone, and 0.13g of chlorogenic acid, dissolve them in 800ml of purified water, adjust the pH value to 7.0 with 10% NaOH, and then add purified water to 1000ml. Filter and distribute to vials, 1ml per bottle. Move the vials to a vacuum freeze dryer for freeze drying. The temperature drops to -40°C within 1 hour, after 2 hours of heat preservation, the vacuum pump is turned on, the vacuum degree is maintained at 300 Pa, and the temperature is gradually raised to -5°C within 10 hours, the vacuum degree is reduced to 10 Pa, and the temperature is raised to +35°C after maintaining for 2 hours. After maintaining for 3 hours, the vacuum degree does not change, and then it is out of the box, capped, inspected, and packaged. Product moisture is not more than 1%.

Embodiment 3

[0038] Example 3 Preparation of freeze-dried oral powder

[0039] Weigh 0.7g of geniposide, 8.0g of baicalin, 0.02g of p-hydroxyacetophenone, and 0.7g of chlorogenic acid, dissolve them in 800ml of purified water, adjust the pH value to 7.0 with 10% NaOH, add purified water to 1000ml, and filter , Packed into vials, 1ml per bottle. Move the vials to a vacuum freeze dryer for freeze drying. The temperature drops to -40°C within 1 hour, after 2 hours of heat preservation, the vacuum pump is turned on, the vacuum degree is maintained at 300 Pa, and the temperature is gradually raised to -5°C within 10 hours, the vacuum degree is reduced to 10 Pa, and the temperature is raised to +35°C after maintaining for 2 hours. After maintaining for 3 hours, the vacuum degree does not change, and then it is out of the box, capped, inspected, and packaged. Product moisture is not more than 1%.

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Abstract

The invention discloses a medicinal composition for preventing and treating neonatal jaundice and a preparation method and application thereof, and belongs to the field of preparation and application of medicaments for the neonatal jaundice. The invention firstly discloses a medicinal composition for preventing and treating the neonatal jaundice. The medicinal composition is prepared from the following components of geniposide, baicalin, p-hydroxyacetophenone and chlorogenic acid. The invention further discloses a method for preparing the medicinal composition. The method comprises the following steps: weighing the geniposide, the baicalin, the p-hydroxyacetophenone and the chlorogenic acid according to parts by mass; dissolving the geniposide, the baicalin, the p-hydroxyacetophenone and the chlorogenic acid in water; adjusting the pH value to 7.0; filtering; performing split charging; performing freeze drying; pressing a cover; performing inspection; packaging to obtain the medicinal composition. The medicinal composition for preventing and treating the neonatal jaundice can be prepared into freeze-dried oral powder, and has the advantages of convenience in taking, definite curative effect, less adverse reactions, low side effect, high security and the like.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating neonatal jaundice, in particular to a pharmaceutical composition for preventing and treating neonatal jaundice, a preparation method and application, and belongs to the field of drug preparation and application for neonatal jaundice. Background technique [0002] In medicine, the jaundice of newborns within 28 days of birth is called neonatal jaundice. Neonatal jaundice refers to the abnormal bilirubin metabolism in the newborn period, which causes the level of bilirubin in the blood to rise, and appears on the skin and mucous membranes. and scleral jaundice. Traditional Chinese medicine generally divides jaundice in children into four types: damp-heat type, heat-toxin type, stasis type, and spleen-dampness type. [0003] Neonatal jaundice is caused by various etiologies. In severe cases, it can endanger the life of children. Currently the most common treatments are bl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P1/16A61K31/216
Inventor 汪六一杨贤龙冯栓何勇吴宗好陈开拓
Owner HEFEI HUAFANG PHARMA SCI & TECH
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