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Application of total saponins in radix polygalae to anti-aging and immunoregulation

A total saponin, anti-aging technology, applied in the anti-aging and immune regulation application fields of polygala total saponins

Active Publication Date: 2017-05-17
SHANXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, ginsenosides, notoginseng saponins, and astragalosides with triterpene saponins as the main active ingredients all have anti-inflammatory and immune effects, but there are few studies on total polygala saponins. Therefore, it is necessary to carry out anti-aging and immune Regulatory research, providing reference for further development of pharmacological effects of polygala saponins

Method used

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  • Application of total saponins in radix polygalae to anti-aging and immunoregulation
  • Application of total saponins in radix polygalae to anti-aging and immunoregulation
  • Application of total saponins in radix polygalae to anti-aging and immunoregulation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1, research on the anti-aging effect of polygala saponins

[0039] Seventy-two SPF-grade Kunming mice, half male and half male, were randomly divided into blank group, positive group, model group, and treatment group (high, medium, and low dose groups), 12 in each group, and were fed adaptively for one week. D-galactose 1.25g·kg was injected into the neck and back of the model group and each administration group -1 , the blank group was subcutaneously injected with an equal volume of normal saline; the positive group was intragastrically administered vitamin E 1.25g·kg -1 , the high, medium and low dose administration groups were given 400, 200, and 100 mg·kg of total saponins of polygala successively -1 , the blank group and the model group were given equal volumes of distilled water. For 4 consecutive weeks, the body weight of the mice was recorded once a week, and the general state of the mice was observed, and the gloss, thinning and activity of the mouse ...

Embodiment 2

[0059] Example 2, research on the immune effect of polygala saponins

[0060] The mice were randomly divided into blank group, model group, positive group, saponin high, medium and low dose groups, each group had 12 mice, half female and half male, and the intraperitoneal injection dose of each group except the blank group was 30mg· kg -1 Cyclophosphamide solution, the blank group was injected with the same dose of normal saline, and the positive group was administered with a dose of 20 mg·kg -1 The levamisole hydrochloride solution, the high, medium and low dose administration groups were given 400, 200, and 100 mg·kg of total saponins of Polygala successively. -1 , the blank group and the model group were administered intragastrically with equal volumes of distilled water for 14 consecutive days.

[0061] After the last administration, fast for 12 hours, weigh the body weight of the mice, take thymus and spleen, weigh the weight to calculate the thymus index and spleen ind...

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Abstract

The invention discloses application of total saponins in radix polygalae to anti-aging and immunoregulation. The total saponins in radix polygalae can be applied to preparation of an anti-aging product or a product for enhancing the immunity function. As proved by researches on the anti-aging effect, compared with a model set, the total saponins in radix polygalae have the advantages that thymus indexes and spleen indexes of the total saponins in radix polygalae in a high dosage set and a middle dosage set are lowered remarkably; the CAT activity of serum is increased remarkably; the SOD activity of the low dosage set is increased remarkably; the differences between the MDA levels and the SOD activities of brain tissues in the high dosage set, the middle dosage set and the low dosage set have statistical significance. Compared with the model set, the differences between the MDA content and the SOD activities of the brain tissues in the high dosage set, the middle dosage set and the low dosage set have statistical significance. As proved by immunity function regulation researches, compared with the model set, the spleen indexes and the thymus indexes of the total saponins in radix polygalae in the high and middle dosage sets are increased remarkably, and the contents of a serum cell factor IL-2 and a serum cell factor IL-6 in the high dosage set are increased remarkably.

Description

technical field [0001] The invention relates to the application of total polygala saponins in anti-aging and immune regulation. Background technique [0002] Polygala is the dry root of Polygala tenuifolia Willd. or Polygalasibirica L., a plant of Polygalaceae. Bitter, pungent, warm. Guixin, kidney, lung meridian. It has the effects of calming the nerves and improving intelligence, communicating with the heart and kidney, eliminating phlegm and reducing swelling. Polygala saponins are one of the main active ingredients. More than 80 different types of polygala saponins have been isolated. The main structure is pentacyclic triterpene type, and the basic core is oleanolic acid. At present, ginsenosides, notoginseng saponins, and astragalosides with triterpene saponins as the main active ingredients all have anti-inflammatory and immune effects, but there are few studies on total polygala saponins. Therefore, it is necessary to carry out anti-aging and immune The research o...

Claims

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Application Information

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IPC IPC(8): A61K36/69A61P39/06A61P37/04
CPCA61K36/69A61K2236/10A61K2236/333A61K2236/39A61K2236/55
Inventor 柴智张娟娟樊慧杰王颖莉马存根
Owner SHANXI UNIV OF CHINESE MEDICINE
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