Stem cell mediated magnetic knife and preparation method and application of same

A technology of stem cells and neural stem cells, applied in the field of biomedicine, can solve the problems of low affinity of target molecules, low specificity, and no outstanding curative effect, and achieve good tissue integration, extremely low immunogenicity, and easy integration Effect

Inactive Publication Date: 2017-05-24
成昱 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, there are many problems in the currently used targeted therapy strategies, and the preliminary clinical research results are still unsatisfactory, and no outstanding curative effect has been achieved.
Taking glioma as an example, there are mainly the following problems: a single targeted drug is difficult to meet the high heterogeneity of glioma cells and kill them; the targeting molecules themselves have low affinity and low specificity, etc. Problems; targeted drugs are easily captured by the reticuloendothelial system during the delivery of intravenous administration; Drugs cannot fully meet the requirements of targeted therapy

Method used

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  • Stem cell mediated magnetic knife and preparation method and application of same
  • Stem cell mediated magnetic knife and preparation method and application of same
  • Stem cell mediated magnetic knife and preparation method and application of same

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specific Embodiment approach

[0037] Preparation of magnetic knife:

[0038] Using Ni80Fe20 alloy as raw material, a nanodisk body with a side length of 2 microns was prepared by optical lithography. The content of iron in Ni80Fe20 alloy is 20%, and the content of nickel is 80%. Production steps such as figure 1 as shown,

[0039] Step 1: Spin-coat the photoresist 11 on the silicon wafer 12 .

[0040] Step 2, placing the mask plate on the upper layer of the previously baked photoresist 11, irradiating it with ultraviolet light, and then using an organic solvent to dissolve and remove the photoresist not exposed to the light. The light leakage area on the mask plate should conform to the shape of the magnetic knife. In this embodiment, the magnetic knife is a square with a side length of 2 microns, so the light leakage area on the mask plate is also a square with a side length of 2 microns.

[0041] Step 3. Deposit a layer of 5nm gold by magnetron sputtering, then deposit a layer of 60nm iron-nickel all...

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Abstract

The invention provides a stem cell mediated magnetic knife and a preparation method and application of the same. The stem cell mediated magnetic knife is characterized by comprising a magnetic knife body and neural stem cells. The magnetic knife body is located in the neural stem cells. The magnetic knife comprises a nanodisk body made of iron-nickel alloy and gold layers, wherein the gold layers are located on the two sides of the nanadisk body respectively, the nanodisk body is in a square shape, and the side length of the nanodisk body is 2 micrometers. According to the stem cell mediated magnetic knife, since the neural stem cells are adopted to serve as a targeted carrier, the tropism of the magnetic knife to brain tumors is higher. Besides, the stem cell mediated magnetic knife is good in tissue integrity and is easy for host cells to integrate structurally, and the normal tissue cannot be damaged.

Description

technical field [0001] The invention relates to a stem cell-mediated magnetic knife, and also relates to a preparation method and application of the stem cell-mediated magnetic knife, belonging to the field of biomedicine. Background technique [0002] Targeted therapy has become a tumor treatment method with great clinical application prospects due to its characteristic of specifically killing tumor cells. It targets cell receptors, key genes, and regulatory molecules, and uses specific carriers to selectively deliver therapeutic drugs or other active substances to the target without affecting the functions of normal cells, tissues, or organs. Thereby improving the curative effect, reducing a kind of treatment plan of side effect. In recent years, people have used biomolecules such as antibodies, peptides, and nucleic acid aptamers to identify glioma cells to construct a wide variety of biomolecular targeting strategies, usually through systemic drug delivery, transported ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/32A61B17/00A61L31/02A61L31/16
Inventor 成昱马特·莱斯尼亚克
Owner 成昱
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