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Targeted antitumor nano drug inhibiting expression of multi-drug resistance genes

A technology of gene expression and nano-drugs, applied in anti-tumor drugs, drug combinations, pharmaceutical formulations, etc., can solve problems such as lack of development, achieve high affinity, inhibit efflux function, and high yield

Inactive Publication Date: 2017-05-31
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are few reports on the new strategy of bifunctionalization on the surface of nanoparticles to increase the concentration of anticancer drugs in tumor cells or tissues, and the preparation and development of bifunctional nanomedicine on the surface of pluronic copolymer and hyaluronic acid has not yet been carried out.

Method used

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  • Targeted antitumor nano drug inhibiting expression of multi-drug resistance genes
  • Targeted antitumor nano drug inhibiting expression of multi-drug resistance genes
  • Targeted antitumor nano drug inhibiting expression of multi-drug resistance genes

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Embodiment

[0034] The embodiment provides a method for preparing targeted chemotherapy and anti-tumor nanomedicine that inhibits the expression of multidrug resistance genes, that is, the method for preparing bifunctional nanoparticles on pluronic and hyaluronic acid surfaces, including the following steps:

[0035] 1) Weigh 50 mg of polylactic acid-glycolic acid copolymer, 25 mg of pluronic and 5 mg of curcumin and dissolve them in 1 mL of dichloromethane-methanol (8:2) solvent;

[0036] 2) Add the above organic solution dropwise to 4 mL of 5% polyvinyl alcohol and 0.5% chitosan aqueous solution;

[0037] 3) Put the above solution in an ice bath immediately and perform ultrasound. The ultrasound parameter is 50% ultrasound amplitude, 10s each time, ultrasound 6 times;

[0038] 4) Pour the above emulsion quickly into 100 mL 0.3% polyvinyl alcohol aqueous solution;

[0039] 5) Under low vacuum conditions, evaporate the organic solvent in the above emulsion;

[0040] 6) Collect the above-mentioned na...

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Abstract

The invention discloses a targeted antitumor nano drug inhibiting expression of multi-drug resistance genes and a preparation method application thereof, and in particular relates to preparation, synthesis and application of the nano drug. The nano drug is prepared as follows: a polylactic acid-glycolic acid copolymer is used as a carrier material, curcumin-loaded nanoparticles are prepared by a solvent evaporation method, and pluronic F127 and hyaluronic acid are used for surface modification. The particle size of the nanoparticles is about 260nm, and the drug loading is about 6.6%. More importantly, the nanoparticles not only can be used for targeted delivery of drugs to tumor cells, but also can effectively inhibit the expression of the multi-drug resistance genes, thereby enhancing the efficacy of chemotherapy and reducing the side effects of the chemotherapy.

Description

Technical field [0001] The invention belongs to the technical field of nano-medicine carriers, and specifically relates to a preparation method and application of a targeted chemotherapy anti-tumor nano-medicine that inhibits the expression of multi-drug resistance genes. Background technique [0002] Among the more than 7 billion people in the world, there are more than 14 million new cancer patients and more than 8.2 million deaths every year. Cancer has become the main cause of death for residents in many countries or regions. In recent years, nanomedicine produced by combining chemotherapy and nanotechnology has been widely used in tumor treatment, mainly because it has controllable drug release characteristics, is easy to penetrate into tumor tissues, and can reduce the systemic toxicity of drugs, etc. . However, due to the low delivery efficiency of nano-drugs, it prevents the lethal dose of the drug from staying in the tumor tissue for a long enough time, thus limiting it...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K31/12A61K47/10A61K47/61A61K47/69A61P35/00
CPCA61K9/5161A61K9/5146A61K31/12
Inventor 肖波司笑莹
Owner SOUTHWEST UNIV
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