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Febrifuge for children

A technology for antipyretics and children, which is applied in antipyretics, drug combinations, and pharmaceutical formulas, etc. It can solve the problems of crying, uneasiness, high risk, and difficult operation of children, and achieves convenient portability, no side effects, and stable effects Effect

Inactive Publication Date: 2017-05-31
ZHENGZHOU ZHENGXIAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral antibiotics in children often cause gastrointestinal reactions, severe allergic reactions and other toxic side effects. At the same time, it is difficult for children to take medicine and it is difficult to operate. Intramuscular injection or intravenous infusion of antibiotics is risky and difficult to operate. Children cry uneasy, very uncooperative

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] An antipyretic for children, the main raw materials in parts by weight are: 23 parts of poplaraxanthin, 19 parts of dipyridamole, 7 parts of dicoumarol, 22 parts of 5-methyl-matrine C, 22 parts of matrine W 35 parts, 5 parts of procuractone, 8 parts of L-hydroxyproline, 4 parts of anisolactone, 2 parts of trizagaloside, 2 parts of apigenin-7-glucuronic acid, 8 parts of brachypine .

[0018] A preparation method of antipyretic for children, the specific steps are:

[0019] First, in the pharmaceutical-grade clean area, according to the above-mentioned metering ratio, take poplaraxanthin, dipyridamole, dicoumarol, 5-methyl-matrine alcohol C, matrine alcohol W, isoporacanthiolactone, L-Hydroxyproline, anisinolactone, trizagaloside, apigenin-7-glucuronic acid, brachypine, sieved, mechanically mixed, added ultrapure water, placed in a pharmaceutical mixer, mixed for 4 minutes, The RSD is controlled to be ≤5%. After mixing, the mixture is pressed into tablets and dried at a...

Embodiment 2

[0021] An antipyretic for children, the main raw materials in parts by weight are: 23 parts of poplaraxanthin, 22 parts of dipyridamole, 12 parts of dicoumarol, 24 parts of 5-methyl-matrine C, 24 parts of matrine W 38 parts, 5 parts of procuractone, 10 parts of L-hydroxyproline, 4 parts of anisolactone, 2 parts of trizagaloside, 2 parts of apigenin-7-glucuronic acid, 8 parts of brachypine .

[0022] A preparation method of antipyretic for children, the specific steps are:

[0023] First, in the pharmaceutical-grade clean area, according to the above-mentioned metering ratio, take poplaraxanthin, dipyridamole, dicoumarol, 5-methyl-matrine alcohol C, matrine alcohol W, isoporacanthiolactone, L-Hydroxyproline, anisinolactone, trizagaloside, apigenin-7-glucuronic acid, brachypine, sieved, mechanically mixed, added ultrapure water, placed in a pharmaceutical mixer, mixed for 4 minutes, The RSD is controlled to be ≤5%. After mixing, the mixture is pressed into tablets and dried at...

Embodiment 3

[0025] An antipyretic for children, the main raw materials in parts by weight are: 24 parts of poplaraxanthin, 24 parts of dipyridamole, 14 parts of dicoumarol, 25 parts of 5-methyl-matrine C, 25 parts of matrine W 42 parts, 8 parts of procuractone, 12 parts of L-hydroxyproline, 6 parts of anisolactone, 3 parts of trizagaloside, 3 parts of apigenin-7-glucuronic acid, 9 parts of brachypine .

[0026] A preparation method of antipyretic for children, the specific steps are:

[0027] First, in the pharmaceutical-grade clean area, according to the above-mentioned metering ratio, take poplaraxanthin, dipyridamole, dicoumarol, 5-methyl-matrine alcohol C, matrine alcohol W, isoporacanthiolactone, L-Hydroxyproline, anisinolactone, trizagaloside, apigenin-7-glucuronic acid, brachypine, sieved, mechanically mixed, added ultrapure water, placed in a pharmaceutical mixer, mixed for 6 minutes, The RSD is controlled to be less than or equal to 5%. After mixing, the mixture is pressed into...

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Abstract

The invention discloses febrifuge for children. The febrifuge is prepared from the following main raw materials in parts by weight: 23-25 parts of tectochrysin, 19-28 parts ofdipyridamole, 7-18 parts of bishydroxycoumarin, 22-27 parts of 5-methoxyl-kushenol C, 35-47 parts of kurarinol W, 5-10 parts of marmesin, 8-16 parts of L-hydroxyproline, 4-7 parts of pimpinellin, 2-3 parts of piceatannol 3'-O-glucoside, 2-4 parts of apigenin-7-glucuronide and 8-9 parts of pinobanksin. Since raw material components are strictly selected according to the recognition on children fever, the febrifuge can achieve the aim of overall recovery, and has the characteristics of quick response, stable effect, convenience in carrying and taking and no toxic or side effect in long-term taking.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to an antipyretic medicine for children. Background technique [0002] Antipyretics are medicines that can dilate blood vessels on the human body surface by regulating human body functions, and then increase heat dissipation through processes such as sweating, while suppressing chills and reducing body heat production. It can effectively control fever and lower body temperature, but it cannot fundamentally eliminate the cause of fever. Fever is one of the common symptoms of many diseases. It is not acceptable to use antipyretics to treat fever regardless of the etiology and condition. Antipyretics have toxic side effects. Antipyretics are commonly used, but their toxic side effects are also common. Such as drug eruption, gastrointestinal tract reaction, blood system reaction and damage to liver and kidney function, etc., especially when such drugs are used for a long time or e...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/519A61K31/37A61K31/352A61K31/401A61P29/00
CPCA61K31/7048A61K31/352A61K31/37A61K31/401A61K31/519A61K2300/00
Inventor 不公告发明人
Owner ZHENGZHOU ZHENGXIAN PHARMA CO LTD
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