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Method for extracting chronic cardiac failure-resistant medicine from periplaneta Americana

A technology for chronic heart failure and American cockroach, which is applied in the field of preparation of anti-chronic heart failure drugs, can solve the problems of electrolyte imbalance, cannot be used for a long time, and cannot fundamentally solve the problems of patients with dyspnea, and achieves the effect of good curative effect.

Inactive Publication Date: 2017-05-31
KUNMING SINOWAY NATURAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(3) Electrolyte disturbance
[0013] It can be seen that the use of diuretics cannot solve the cause of heart failure. Long-term use of vasodilators will accelerate the aging of blood vessels and cannot be used for a long time. Oxygen inhalation can only be used as a supplementary means of oxygen and cannot fundamentally solve the patient's dyspnea question

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] A method for extracting anti-chronic heart failure medicine from Periplaneta americana, realized by the following methods:

[0056] A, the fresh worm of Periplaneta americana adopts the hot water of 80 ℃ to kill, and temperature control is dried in the range of 60 ℃ ± 5 ℃, pulverizes, crosses 24 mesh sieves, makes the meal of Periplaneta americana;

[0057] B, step A gained Periplaneta americana coarse powder is carried out reflux extraction 3 times at 75 ℃ of temperature, when extracting for the first time, increase the ethanol of 5 times of concentration of coarse powder weight, extraction time is 4 hours; Second time Afterwards, add 90% ethanol with 3 times the weight of coarse powder each time, and the extraction time is 3 hours; during the extraction process, the temperature of ethanol is maintained at 75°C. After the extraction is completed, the extracts are combined and filtered to obtain the ethanol extract;

[0058] C. Concentrating the ethanol extract obtained...

Embodiment 2

[0070] A method for extracting anti-chronic heart failure medicine from Periplaneta americana, realized by the following methods:

[0071] A, the fresh worm of Periplaneta americana adopts 90 ℃ hot water to kill, and temperature control is dried in the range of 60 ℃ ± 5 ℃, pulverizes, crosses 24 mesh sieves, makes the meal of Periplaneta americana;

[0072] B, step A gained Periplaneta americana coarse powder is carried out reflux extraction 5 times at 80 ℃ of temperature, when extracting for the first time, add the ethanol of 8 times of concentration 95% of coarse powder weight, extraction time is 6 hours; Second time Add 95% ethanol with a concentration of 6 times the weight of coarse powder each time, and the extraction time is 5 hours; during the extraction process, the temperature of ethanol is kept at 80°C. After the extraction is completed, the extracts are combined and filtered to obtain the ethanol extract;

[0073] C. Concentrate the ethanol extract obtained in step ...

Embodiment 3

[0085] A method for extracting anti-chronic heart failure medicine from Periplaneta americana, realized by the following methods:

[0086] A, the fresh worm of Periplaneta americana adopts 85 ℃ hot water to kill, and temperature control is dried in the range of 60 ℃ ± 5 ℃, pulverizes, crosses 24 mesh sieves, makes the meal of Periplaneta americana;

[0087] B, be 90% ethanol reflux with concentration and extract Periplaneta americana coarse powder three times: when extracting for the first time, increase the ethanol of 6 times of concentration of coarse powder weight, extraction time is 5 hours; Increase the weight of coarse powder for the second time 4 times the concentration of 90% ethanol, the extraction time is 4 hours; the third time to increase the weight of coarse powder 4 times the concentration of 90% ethanol, the extraction time is 4 hours. During the extraction process, the ethanol temperature was maintained at 75°C. After the extraction was completed, the three ext...

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PUM

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Abstract

The invention relates to a method for extracting a chronic cardiac failure-resistant medicine from periplaneta Americana. The method comprises the following steps of A, killing fresh periplaneta Americana insects, drying, and crushing, so as to obtain crude powder; B, refluxing and extracting the crude powder by 90-95% ethyl alcohol at the temperature of 75 to 80 DEG C, so as to obtain ethyl alcohol extracting liquid; C, concentrating the ethyl alcohol extracting liquid, so as to obtain ethyl alcohol concentrated liquid; D, adding distilled water into the ethyl alcohol concentrated liquid, and adsorbing by activated carbon; E, charging medicine liquid containing the activated carbon into a chromatographic column, draining the medicine liquid, washing by water, and concentrating, so as to obtain clear ointment; F, flushing a cation exchange resin column by an HCl solution, and changing cation exchange resin into an H<+> type; G, charging an acidified periplaneta Americana clear ointment solution onto the column; H, adding water into the cation exchange resin column, and discarding flowing-out liquid; I, adding an NaOH water solution into the cation exchange resin column, and collecting flowing-out liquid; J, adding HCl into the flowing-out liquid to neutralize, and concentrating, so as to obtain flowing ointment; K, adding alcohol into the flowing ointment, filtering, and concentrating, so as to obtain periplaneta Americana cardiac failure-resistant extract ointment. The extract has a better therapy effect on the chronic cardiac failure diseases.

Description

technical field [0001] The invention relates to a preparation method of a medicine, in particular to a preparation method of an anti-chronic heart failure medicine. Background technique [0002] The clinical manifestations of chronic heart failure are closely related to which side of the ventricle or atrium is involved, and left heart failure is the most common clinically. The clinical features of left heart failure are mainly pulmonary stasis and pulmonary edema caused by left atrium and (or) right ventricle failure; while the clinical features of right heart failure are systemic venous stasis and pulmonary edema caused by right atrium and (or) right ventricle failure. Water and sodium retention, after the left heart failure occurs, the right heart often also suffers from functional damage one after another, eventually leading to total heart failure. When right heart failure occurs, the symptoms of left heart failure can be alleviated. Currently commonly used treatment met...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61P9/04
CPCA61K35/63
Inventor 郝振平徐溧
Owner KUNMING SINOWAY NATURAL PHARMA
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