Method for extracting chronic cardiac failure-resistant medicine from periplaneta Americana

Abstract

The invention relates to a method for extracting a chronic cardiac failure-resistant medicine from periplaneta Americana. The method comprises the following steps of A, killing fresh periplaneta Americana insects, drying, and crushing, so as to obtain crude powder; B, refluxing and extracting the crude powder by 90-95% ethyl alcohol at the temperature of 75 to 80 DEG C, so as to obtain ethyl alcohol extracting liquid; C, concentrating the ethyl alcohol extracting liquid, so as to obtain ethyl alcohol concentrated liquid; D, adding distilled water into the ethyl alcohol concentrated liquid, and adsorbing by activated carbon; E, charging medicine liquid containing the activated carbon into a chromatographic column, draining the medicine liquid, washing by water, and concentrating, so as to obtain clear ointment; F, flushing a cation exchange resin column by an HCl solution, and changing cation exchange resin into an H<+> type; G, charging an acidified periplaneta Americana clear ointment solution onto the column; H, adding water into the cation exchange resin column, and discarding flowing-out liquid; I, adding an NaOH water solution into the cation exchange resin column, and collecting flowing-out liquid; J, adding HCl into the flowing-out liquid to neutralize, and concentrating, so as to obtain flowing ointment; K, adding alcohol into the flowing ointment, filtering, and concentrating, so as to obtain periplaneta Americana cardiac failure-resistant extract ointment. The extract has a better therapy effect on the chronic cardiac failure diseases.

Description

technical field

[0001] The invention relates to a preparation method of a medicine, in particular to a preparation method of an anti-chronic heart failure medicine. Background technique

[0002] The clinical manifestations of chronic heart failure are closely related to which side of the ventricle or atrium is involved, and left heart failure is the most common clinically. The clinical features of left heart failure are mainly pulmonary stasis and pulmonary edema caused by left atrium and (or) right ventricle failure; while the clinical features of right heart failure are systemic venous stasis and pulmonary edema caused by right atrium and (or) right ventricle failure. Water and sodium retention, after the left heart failure occurs, the right heart often also suffers from functional damage one after another, eventually leading to total heart failure. When right heart failure occurs, the symptoms of left heart failure can be alleviated. Currently commonly used treatment met...