Combined application of statin and adrenocortical hormone medicaments to treatment of chronic subdural hematoma

A technology of adrenal cortex and hormones, applied in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of patients with complications, long cycle of chronic subdural hematoma, etc., and achieve shortened treatment cycle and broad Application prospect and clinical significance, effect of avoiding pain

Active Publication Date: 2017-05-31
张建宁 +2
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Problems solved by technology

[0007] The purpose of the present invention is to solve the long period of clinical use of statins in the treatment of chronic subdural hematoma, and to overcome the technical prejudice of those skilled in the art on the amount of hormone used, and the use of high-dose hormones brings a large number of complications to patients, etc. question

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  • Combined application of statin and adrenocortical hormone medicaments to treatment of chronic subdural hematoma
  • Combined application of statin and adrenocortical hormone medicaments to treatment of chronic subdural hematoma
  • Combined application of statin and adrenocortical hormone medicaments to treatment of chronic subdural hematoma

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Embodiment Construction

[0057] In order to further explain the technical solution of the present invention and the technical effects achieved by it, the present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0058] 1. Low-dose atorvastatin promotes the absorption of subdural hematoma

[0059] By improving the subdural model of rats, and according to different doses of oral atorvastatin, the experimental animals were divided into 3 groups: control group, low dose group (3mg / kg / day, equivalent to 10-20mg / day for adults) ) and high-dose group (8mg / kg / day, equivalent to 80-100mg / day for adults). The dynamic changes of hematoma volume in rats were observed by MRI. HE staining, transmission electron microscopy, immunohistochemistry, flow cytometry, real-time quantitative PCR, and ELISA were used to measure the physiological structure characteristics of neohematoma capsule disease, the number of peripheral blood endothelial progenitor cells, new b...

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Abstract

The invention discloses combined application of statin and adrenocortical hormone medicaments to treatment of chronic subdural hematoma. Through combined application of the medicaments, hematoma absorption can be accelerated remarkably, the curative effect of other oral statins is improved greatly, and other side effects are avoided; moreover, the dosage of the adrenocortical hormone medicament is one tenth of the dosage of hormone, and the incidence of relevant complications caused by hormone treatment is lowered greatly. Through the technical scheme of combined application of the medicaments, a good curative effect is achieved, and wide application prospect and clinical significance are achieved.

Description

technical field [0001] The invention belongs to the field of medical preparations containing active ingredients, and in particular relates to the combined application of statins, dexamethasone and structural analogues thereof in the treatment of chronic subdural hematoma. Background technique [0002] People have been exploring and researching chronic subdural hematoma (CSDH) for more than a century, and the earliest can be traced back to more than 150 years ago. According to literature records, it was Virchow who first proposed the study on the mechanism of chronic subdural hematoma formation. He first described the disease in 1857 and put forward the hypothesis that inflammatory hemorrhage in the inner dura mater is the cause of CSDH, namely: Pachymeningitis Theory. Later, a series of studies such as pathological detection and electron microscope observation found that the capsule of chronic subdural hematoma contained a large number of abnormal sinus-shaped lacunar blood ...

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Application Information

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IPC IPC(8): A61K45/06A61K31/573A61K31/40A61P25/00
CPCA61K31/40A61K31/573A61K45/06A61K2300/00A61K31/366A61K31/505A61P25/00
Inventor 张建宁江荣才王东权伟
Owner 张建宁
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