Combined application of statin and adrenocortical hormone medicaments to treatment of chronic subdural hematoma
A technology of adrenal cortex and hormones, applied in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of patients with complications, long cycle of chronic subdural hematoma, etc., and achieve shortened treatment cycle and broad Application prospect and clinical significance, effect of avoiding pain
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[0057] In order to further explain the technical solution of the present invention and the technical effects achieved by it, the present invention will be further described below in conjunction with the accompanying drawings and embodiments.
[0058] 1. Low-dose atorvastatin promotes the absorption of subdural hematoma
[0059] By improving the subdural model of rats, and according to different doses of oral atorvastatin, the experimental animals were divided into 3 groups: control group, low dose group (3mg / kg / day, equivalent to 10-20mg / day for adults) ) and high-dose group (8mg / kg / day, equivalent to 80-100mg / day for adults). The dynamic changes of hematoma volume in rats were observed by MRI. HE staining, transmission electron microscopy, immunohistochemistry, flow cytometry, real-time quantitative PCR, and ELISA were used to measure the physiological structure characteristics of neohematoma capsule disease, the number of peripheral blood endothelial progenitor cells, new b...
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