Nano material for tumor imaging and treatment and preparation method of nano material

A nanomaterial and tumor imaging technology, applied in the field of nanomaterials, can solve problems such as large side effects and poor targeting effect of tumor treatment drugs, and achieve the effects of less toxic side effects, low equipment requirements, and easy operation.

Active Publication Date: 2017-05-31
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above deficiencies, the object of the present invention is to provide a nanomaterial for tumor imaging and treatment and its preparation method, which overcomes the independent diagnosis and treatment encountered in the current cancer diagnosis and treatment pro

Method used

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  • Nano material for tumor imaging and treatment and preparation method of nano material
  • Nano material for tumor imaging and treatment and preparation method of nano material
  • Nano material for tumor imaging and treatment and preparation method of nano material

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Embodiment 1

[0037] The embodiment of the present invention provides a nano material for tumor imaging and treatment and a preparation method thereof, including the following steps:

[0038] (1) Add FeCl 3 ·6H 2 O and sodium oleate (molar ratio 1:1) are added to the mixture of ethanol, deionized water and n-hexane (volume ratio 4:3:7). After the ultrasonic dissolution is complete, it is stirred with a PTFE stirring blade. Condensate and reflux at 70°C and heat in an oil bath for 4 hours to obtain a reddish-brown viscous liquid. Transfer it to a pear-shaped separatory funnel, add an appropriate amount of deionized water, shake, stand still, discard the water phase, repeat washing 3 times, and take The oil phase was vacuum dried at 110°C overnight to obtain iron oleate;

[0039] (2) Using thermal cracking method, take the iron oleate, oleic acid and octadecene (molar ratio of 2:1:39.6) prepared in step (1) in a three-necked flask, after the ultrasonic dispersion is complete, under vacuum , Heati...

Embodiment 2

[0048] The embodiment of the present invention provides another nanomaterial for tumor imaging and treatment and a preparation method thereof, including the following steps:

[0049] (1) Add FeCl 3 ·6H 2 O and sodium oleate (molar ratio 1:1) are added to the mixture of ethanol, deionized water and cyclohexane (volume ratio 4:3:7), after the ultrasonic dissolution is complete, under the stirring of PTFE stirring blade , Condensate and reflux at 60°C, heat in an oil bath for 6 hours to obtain a reddish brown viscous liquid, transfer it to a pear-shaped separatory funnel, add an appropriate amount of deionized water, shake, stand still, discard the water phase, and repeat the washing 3 times. Take the oil phase and dry it in vacuum at 140°C overnight to obtain iron oleate;

[0050] (2) Using the thermal cracking method, take the iron oleate, oleic acid and octadecene (molar ratio of 2:1:39.6) prepared in step (1) in a three-necked flask. After the ultrasonic dispersion is complete, un...

Embodiment 3

[0068] The embodiment of the present invention provides another nanomaterial for tumor imaging and treatment and a preparation method thereof, including the following steps:

[0069] (1) Add FeCl 3 ·6H 2 O and sodium oleate (molar ratio 1:1) are added to the mixture of ethanol, deionized water and n-hexane (volume ratio 4:3:7), after the ultrasonic dissolution is complete, under magnetic stirring, 80℃ Condensate and reflux, heat in an oil bath for 3 hours to obtain a reddish brown viscous liquid, transfer it to a pear-shaped separatory funnel, add an appropriate amount of deionized water, shake, stand still, discard the water phase, repeat the washing 3 times, and take the oil phase Dry under vacuum at 100°C overnight to obtain iron oleate;

[0070] (2) Using the thermal cracking method, take the iron oleate, oleic acid and octadecene (molar ratio of 2:1:39.6) prepared in step (1) in a three-necked flask. After the ultrasonic dispersion is complete, under vacuum , Heat at 120°C fo...

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Abstract

The invention discloses a nano material for tumor imaging and treatment and a preparation method of the nano material. The nano material, which has functions of magnetic targeting, magnetic resonance imaging (MRI), up-conversion luminescence and photothermal therapy and is capable of achieving integrated diagnosis and treatment of tumors, is prepared by the following steps: firstly, preparing Fe3O4 nanocrystal by virtue of a thermal cracking process; then, on the basis of a self-assembling process, preparing a hollow polymer shell nanosphere which has a cavity and contains the Fe3O4 nanocrystal therein, carbonizing the shell and loading an up-conversion luminescence nanoparticle layer on the surface of the carbon shell by virtue of a solvent evaporation method; and finally, conducting surface modification by virtue of PEG (polyethylene glycol). The nano material, which is of a shell-core structure, comprises an external shell layer and an internal core; the external shell layer comprises the carbonized polymer shell layer; the up-conversion luminescence nanoparticle (UCNPs) layer is additionally attached to the carbonized polymer shell layer; the up-conversion luminescence nanoparticle layer is subjected to mPEG surface modification; and the internal core is Fe3O4 nanocrystal which is uniformly dispersed in the internal cavity and is superparamagnetic.

Description

Technical field [0001] The invention relates to a nano material, in particular to a nano material used for tumor imaging and treatment. Background technique [0002] The "World Cancer Report" pointed out that the global cancer incidence and mortality rates are on the rise. Approximately 4.3 million people were diagnosed with cancer in China in 2015, and 2.8 million died from cancer, an average of 7500 people per day. Cancer brings great pain to patients, families, and society. Therefore, the diagnosis and treatment of cancer has become a top priority in medical research. [0003] In the imaging diagnosis of cancer, magnetic resonance imaging (Magnetic Resonance Imaging, MRI) is a non-invasive imaging method with high tissue resolution and can achieve all-round imaging. In addition, the upconversion luminescent material uses near-infrared light as the excitation source, the penetration depth of the light is deep, there is no biological background fluorescence, and the biocompatibi...

Claims

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Application Information

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IPC IPC(8): A61K49/12A61K49/18A61K49/00A61K41/00A61K47/69A61K47/60A61P35/00
Inventor 刘金亮施利毅王佳昕孙丽宁牟晓明
Owner SHANGHAI UNIV
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