The production technology of ampicillin sodium crystal
A technology of ampicillin sodium and production process, applied in the direction of organic chemistry and the like, can solve the problems of long sublimation drying time, poor product quality, long freezing time, etc., and achieve the effects of shortening sublimation drying time, improving sublimation rate and facilitating sublimation
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Embodiment 1
[0026] Prepare the following raw materials: Ampicillin 60g, 10% NaOH solution (density 1.1g / cm 3 ) 54ml, water for injection 55ml, tert-butanol (density 0.81g / ml) 13ml, vitamin C 2g, EDTA-disodium 0.2g.
[0027]Specific process operation steps: add 55ml of water for injection at 0-5°C and 13ml of tert-butanol into the reactor, start stirring, add 60g of ampicillin and 0.2g of EDTA-disodium in turn and stir to form a suspension solution, slowly add 10ml of water below 4°C % sodium hydroxide solution 54ml until the solution is translucent, the pH value at the end of the solution is controlled at 9.3 After the reaction is completed, add vitamin C2g and activated carbon with a total solution volume of 1-3‰ in the reactor and stir evenly. After decarburization and 0.2um precision filtration, the solution that has completed the reaction is evenly poured into the tray of the freeze-drying equipment, the freeze-drying process is started, the temperature of the solution is lowered to -...
Embodiment 2
[0029] Prepare the following raw materials: Ampicillin 40g, 10% NaOH solution (density 1.1g / cm 3 ) 38ml, water for injection 35ml, tert-butanol (density 0.81g / ml) 12ml, vitamin C1g, EDTA-disodium 0.1g.
[0030] Specific process operation steps: add 35ml of water for injection at 1-4°C and 12ml of tert-butanol into the reactor, start stirring, add 40g of ampicillin and 0.4g of EDTA-disodium in turn and stir to form a suspension solution, slowly add 10ml of water below 3°C % sodium hydroxide solution 38ml until the solution is translucent, the pH value of the solution end point is controlled at 9.7 After the reaction is completed, add vitamin C1g and activated carbon with a total solution volume of 1-3‰ in the reactor and stir evenly. After decarburization and 0.2um precision filtration, the solution that has completed the reaction is evenly poured into the tray of the freeze-drying equipment, the freeze-drying process is started, the temperature of the solution is lowered to -3...
Embodiment 3
[0032] Prepare the following raw materials: Ampicillin 45g, 10% NaOH solution (density 1.1g / cm 3 ) 40ml, water for injection 40ml, tert-butanol (density 0.81g / ml) 14ml, vitamin C 1.3g, EDTA-disodium 0.13g.
[0033] Specific process steps: Add 40ml of water for injection at 2-3°C and 14ml of tert-butanol into the reactor, start stirring, add 45g of ampicillin and 0.13g of EDTA-disodium in turn and stir to form a suspension solution, slowly add 10 ml of water below 4°C 40ml of sodium hydroxide solution until the solution is translucent, and the pH value at the end of the solution is controlled at 9.6. After the reaction is completed, add 1.3g of vitamin C and activated carbon with a total volume of 1-3‰ of the solution in the reactor and stir evenly. After decarburization and 0.2um precision filtration, the solution that has completed the reaction is evenly poured into the tray of the freeze-drying equipment, the freeze-drying process is started, the temperature of the solution ...
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