Loaded chitosan/sodium alginate double-crosslinking hydrogel and preparation method and application thereof

A sodium alginate, double cross-linking technology, applied in the field of biomedical engineering materials, can solve the problems of drug leakage, fast drug release, poor targeting, etc. Good swelling effect

Active Publication Date: 2017-05-31
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This will cause a chain reaction. Although the drug can treat specific symptoms, it will cause other symptoms. The current commonly used drugs have problems such as poor targeting, high toxicity, and easy loss of drugs. Therefore, in order to overcome the above shortcomings, bioadhesive The drug carrier of attached colon-targeted drug delivery system has become a research hotspot in the field of medical engineering
[0003] Zhang Lina etc. disclose a kind of preparation method and application of carboxymethyl chitosan and sodium alginate blend microcapsule (CN200310111493.8), but the sodium alginate/carboxymethyl chitosan microcapsule of wherein lo...

Method used

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  • Loaded chitosan/sodium alginate double-crosslinking hydrogel and preparation method and application thereof
  • Loaded chitosan/sodium alginate double-crosslinking hydrogel and preparation method and application thereof
  • Loaded chitosan/sodium alginate double-crosslinking hydrogel and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1: Preparation of drug-loaded (doxorubicin hydrochloride) chitosan / sodium alginate double cross-linked hydrogel with colon targeting

[0048] (1) Weigh 0.312 g of chitosan (its molecular weight is 600,000), dissolve it in 20 ml of deionized water at room temperature, mechanically stir at room temperature, add 0.5 ml of acetic acid and stir to dissolve.

[0049] (2) Weigh 0.01 g of doxorubicin hydrochloride (Dalian Meilun Biotechnology Co., Ltd.) and dissolve it in 5 ml of deionized water (in the dark).

[0050] (3) Add the solution in (2) into the solution in (1) and continue mechanical stirring (the whole experiment should be protected from light).

[0051] (4) the sodium alginate that takes again by weighing 0.417g is dissolved in the solution that step (3) obtains and mechanically stirred for 1h, adjusts pH value to 5 with the NaOH of 0.1M and obtains the chitosan / alginic acid that is loaded with doxorubicin hydrochloride For sodium hydrogel, the chitosan / so...

Embodiment 2

[0053] Example 2: Preparation of drug-loaded (doxorubicin hydrochloride) chitosan / sodium alginate double cross-linked hydrogel with colon targeting

[0054] (1) Weigh 0.208 g of chitosan (its molecular weight is 600,000), dissolve it in 20 ml of deionized water at room temperature, mechanically stir at room temperature, add 0.5 ml of acetic acid and stir to dissolve.

[0055] (2) Weigh 0.01 g of doxorubicin hydrochloride (Dalian Meilun Biotechnology Co., Ltd.) and dissolve it in 5 ml of deionized water (in the dark).

[0056] (3) Add the solution in (2) into the solution in (1) and continue mechanical stirring (the whole experiment should be protected from light).

[0057] (4) Dissolve 0.417g of sodium alginate in the solution obtained in step (3) and mechanically stir for 1h, adjust the pH value to 5 with 0.1M NaOH to obtain chitosan / alginic acid loaded with doxorubicin hydrochloride For sodium hydrogel, the chitosan / sodium alginate blend gel loaded with doxorubicin hydrochl...

Embodiment 3

[0059] Example 3: Preparation of drug-loaded (doxorubicin hydrochloride) chitosan / sodium alginate double cross-linked hydrogel with colon targeting

[0060] (1) Weigh 0.156 g of chitosan (its molecular weight is 600,000), dissolve it in 20 ml of deionized water at room temperature, mechanically stir at room temperature, add 0.5 ml of acetic acid and stir to dissolve.

[0061] (2) Weigh 0.01 g of doxorubicin hydrochloride (Dalian Meilun Biotechnology Co., Ltd.) and dissolve it in 5 ml of deionized water (in the dark).

[0062] (3) Add the solution in (2) into the solution in (1) and continue mechanical stirring (the whole experiment should be protected from light).

[0063] (4) take again the sodium alginate of 0.469g and dissolve in the solution that step (3) obtains and mechanically stir for 1h, adjust the pH value to 5 with 0.1M NaOH, obtain chitosan / seaweed loaded with doxorubicin hydrochloride Sodium alginate hydrogel, the chitosan / sodium alginate hydrogel that will be lo...

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Abstract

The invention belongs to the field of biomedical engineering materials, and discloses a loaded chitosan (CS)/sodium alginate (SALG) double-crosslinking hydrogel with a colon target and a preparation method and an application thereof. In the invention, the hydrogel is firstly crosslinked with chitosan and then with sodium alginate, the medicine is wrapped in the chitosan, the sodium alginate is coated on the outer layer, and then double crosslinking is performed by the calcium ion and glutaraldehyde, the carboxy and amine are both fixed to form an interpenetrated network, and such a structure is not easy to be degraded and not easy to lose in the body fluid of human beings. After medicine loading, a small amount of medicine can be released after two hours in the gastric juice, and nearly no medicine is released after 4 hours in the intestine, while more medicine is released in the colon, and long-time release can be realized, which makes up the medicine burst release, medicine leakage and easy degradation and loose of materials reflected by the loaded gel prepared in the above, and colon targeting positioning and long-time release of medicine for treatment can be realized.

Description

technical field [0001] The invention belongs to the field of biomedical engineering materials, in particular to a drug-loaded chitosan (CS)-sodium alginate (SALG) double cross-linked hydrogel with colon targeting, a preparation method and application thereof. Background technique [0002] For a long time, the medical field has continued to use the medicinal principle of "no intramuscular injection if it can be taken orally, and no intravenous infusion if it can be injected intramuscularly". However, people often use infusion therapy for high efficiency. Its hazards and adverse reactions are also prominent, and improper infusion therapy will cause serious harm to the health of patients! Mainly decreased lung function. Long-term infusion will increase the burden on the heart and kidneys. Excessive infusion is often accompanied by the abuse of a large number of antibiotics, resulting in a decrease in the body's flora imbalance, decreased immunity, and increased bacterial resis...

Claims

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Application Information

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IPC IPC(8): C08J3/24C08J3/075A61K9/52A61K47/36
CPCA61K9/0009A61K9/5036C08J3/075C08J3/246C08J2305/04C08J2405/08
Inventor 马栋苗樱薛巍
Owner JINAN UNIVERSITY
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