A kind of green fruit extract and its preparation method and application

A technology of extract and cypress fruit, applied in the directions of pharmaceutical formulations, drug combinations, plant raw materials, etc., can solve problems such as water and electrolyte disorders, nutritional disorders, and easy recurrence, and achieve the effects of improving abdominal pain, reducing expression, and improving SOD activity.

Active Publication Date: 2020-09-15
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has the characteristics of high morbidity, slow recovery after treatment and easy recurrence. If the treatment is not timely, it can cause diarrhea, water and electrolyte disorders, nutritional disorders, etc., and make the disease worse.
At present, there is no effective treatment drug or method. Generally, symptomatic treatment is selected, mainly Western medicine, such as anti-inflammatory and pain relief, rehydration and antidiarrheal, etc., but the effect is often poor, which brings great inconvenience and pain to the work and life of the patient.

Method used

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  • A kind of green fruit extract and its preparation method and application
  • A kind of green fruit extract and its preparation method and application
  • A kind of green fruit extract and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Preparation of Green Fruit Extract

[0025] (1) After crushing 500g green fruit, pass through a 40-mesh sieve, take the under-sieve, and use supercritical fluid extraction method to extract it with supercritical CO 2 As a supercritical extractant, the green fruit with a particle size of -40 mesh was extracted. The extraction was carried out at 40°C and 300 bar at a speed of 0.62g / min for 6 hours, and the extract was collected every 20 minutes;

[0026] (2) Using a supercritical fluid extraction device, with acetone as the extraction agent, the green fruit after the treatment in step (1) is extracted again to obtain the extract A. Extract at a rate of g / min for 6 hours, and collect the extract every 20 minutes;

[0027] (3) Using a supercritical fluid extraction device, water is used as the extraction agent to extract the green fruit after the treatment in step (2) again to obtain the extract B. Extract at a rate of g / min for 6 hours, and collect the extract every 20 m...

Embodiment 2

[0030] Preparation of Green Fruit Extract

[0031] (1) After crushing 400g green fruit, pass it through a 40-mesh sieve, take the under-sieve, and use supercritical fluid extraction method to extract it with supercritical CO 2 As a supercritical extractant, the green fruit with a particle size of -40 mesh was extracted. The extraction was carried out at 45°C and 350 bar at a speed of 0.58g / min for 6 hours, and the extract was collected every 20 minutes;

[0032] (2) Using a supercritical fluid extraction device, with acetone as the extraction agent, the green fruit after the treatment in step (1) is extracted again to obtain the extract A. Extract at a rate of g / min for 6 hours, and collect the extract every 20 minutes;

[0033] (3) Using a supercritical fluid extraction device, water is used as the extraction agent to extract the green fruit after the treatment in step (2) again to obtain the extract B. Extract at a rate of g / min for 6 hours, and collect the extract every 2...

Embodiment 3

[0036] Preparation of Green Fruit Extract

[0037] (1) After crushing 500g green fruit, pass through a 40-mesh sieve, take the under-sieve, and use supercritical fluid extraction method to extract it with supercritical CO 2 As a supercritical extractant, the green fruit with a particle size of -40 mesh was extracted. The extraction was carried out at a speed of 1.0 g / min for 6 hours at 35°C and 450 bar, and the extract was collected every 20 minutes;

[0038] (2) Using a supercritical fluid extraction device, with acetone as the extraction agent, the green fruit after the treatment in step (1) is extracted again to obtain the extract A. Extract at a rate of g / min for 6 hours, and collect the extract every 20 minutes;

[0039] (3) Using a supercritical fluid extraction device, water is used as the extraction agent to extract the green fruit after the treatment in step (2) again to obtain the extract B. Extract at a rate of g / min for 6 hours, and collect the extract every 20 m...

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Abstract

The invention relates to a fructus chebulae immaturus extract and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine preparation. The fructus chebulae immaturus extract has the effects of clearing away heat and toxic materials, astringing to arrest diarrhea, resisting inflammation and oxidization and the like, and can be used for repairing radioactive injuries, treating intestinal mucosal hyperemia, edema and cell injuries caused by radiographic exposure, and improving the symptoms of stomachache, diarrhea, bloody purulent stool and the like. As proved by experiments, the fructus chebulae immaturus extract can be used for resisting inflammatory injury caused by radiation at a certain degree, lowering the expression of an inflammatory factor TNF-alpha, and increasing the SOD (Superoxide Dismutase) activity of an oxidation-resistant active enzyme (p is less than 0.05). The fructus chebulae immaturus extract can be used for preparing radioactive enteritis medicine, and a novel method is provided for clinical treatment of radioactive enteritis.

Description

technical field [0001] The invention belongs to the technical field of preparation of Chinese herbal medicines, and in particular relates to a green fruit extract and its preparation method and application. Background technique [0002] With the worsening of environmental pollution, food insecurity and increasing social pressure, the incidence of malignant tumors is increasing. In clinical treatment of malignant tumors such as abdomen or pelvis, in addition to surgery, chemotherapy and other means, it is often used together or alone. Radiation Therapy. Among them, radiation proctitis is a common intestinal complication caused by radiation therapy of malignant tumors such as the pelvis, which can involve the small intestine, colon, and rectum, so it is also called radiation rectum, colon, and enteritis. It has the characteristics of high morbidity, slow recovery after treatment and easy recurrence. If the treatment is not timely, it can cause diarrhea, water and electrolyte ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P1/00
CPCA61K36/185A61K2236/33A61K2236/331A61K2236/37A61K2236/39A61K2236/51
Inventor 刘松青刘芳赵鸿燕谢永红戴青
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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