A kind of coating method of double biomimetic dopamine phosphorylcholine substance

A technology of dopamine phosphorylcholine and phosphorylcholine, which is applied in the coating field of double biomimetic dopamine phosphorylcholine substances, can solve problems such as difficulties in preparation, and achieve broad application prospects, mild conditions, and simple preparation methods
CN106832382BInactive Publication Date: 2020-11-13XIAN UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
XIAN UNIV OF SCI & TECH
Publication Date
2020-11-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a synthesis and coating method of a double bionic dopamine and phosphorylcholine substance. The synthesis and coating method comprises the following steps of enabling a vinyl monomer containing a phosphorylcholine group and dopamine hydrochloride to generate Michael addition reaction in a polarity solvent at certain temperature, so as to obtain the double bionic dopamine and phosphorylcholine substance; thinning a reaction solution, coating the surface of the to-be-modified material, airing, heating at high temperature, treating by a Tris-HCl solution, adhering to the surface of a substrate, and building a bionic cell outer membrane structure. A preparation method of a coating with the bionic cell outer membrane structure has the advantages that the preparation method is simple, and the conditions are mild; a novel path is provided for obtaining a stable phosphorylcholine bionic coating, and the important academic meaning is realized for modifying the biological compatibility of the biological material. A modifying material with the bionic cell outer membrane structure has broad application prospect in the fields of in-vivo implant materials, tissue engineering, medicine slow release, biological sensors and the like.
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Description

technical field

[0001] The invention relates to the technical fields of material surface science and biomedical polymer materials, in particular to a method for coating double biomimetic dopamine phosphorylcholine substances. Background technique

[0002] When the material is used in a living body, it is easy to non-specifically adsorb proteins, activate complement molecules and the immune system, thereby causing blood coagulation, immune and inflammatory reactions, resulting in a significant decrease in its performance or even failure. This is due to the poor biocompatibility of materials, therefore, biocompatibility research has become the primary issue in the field of biomaterial research. The surface of a material is the medium through which the material contacts the organism. Surface charge, hydrophilicity / hydrophobicity, chemical composition, and morphology are important factors that affect the interface interaction between the material and the organism, and determine ...

Claims

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