Mesoporous organosilicon-gold nano-triangular sheet composite material loaded with photosensitizer and its preparation method and application
A technology of mesoporous silicone and composite materials, applied in photodynamic therapy, wave energy or particle radiation treatment materials, medical preparations with non-active ingredients, etc., can solve the problems of high early release rate and low loading efficiency, etc. Good dispersion, high loading efficiency, and high morphological and dimensional stability
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Embodiment 1
[0033] (1) Preparation and identification of aromatic mesoporous organic silica layer-wrapped gold nanotriangular sheets
[0034] (1) 25.4mM chloroauric acid solution and 0.1M sodium hydroxide solution are mixed according to the molar ratio of 1:1, and 100 μL of the resulting solution is added to 10 mL of a mixed aqueous solution containing 16mM cetyltrimethylammonium chloride and 0.75mM potassium iodide and shake gently; then add 100 μL 64mM ascorbic acid to the obtained solution, shake gently until the solution becomes colorless, then add 5 μL 0.1M sodium hydroxide, and mix quickly; stand at room temperature for 0.5-1h, then The product is centrifuged and washed at room temperature;
[0035](2) Transfer the product obtained in step (1) to water for dispersion, add 2 mL of the dispersion with an absorbance of 3.0 to 10 mL of a 20 mM cetyltrimethylammonium chloride aqueous solution, 0.1 mL of ammonia, and 2.9 mL of ethanol and mix In the solution, add 0.1mL of 10wt% 1,4-bis(t...
Embodiment 2
[0059] (1) Preparation of aromatic mesoporous organic silica layer-wrapped gold nanotriangular sheets
[0060] (1) 20mM chloroauric acid solution and 0.05M sodium hydroxide solution are mixed according to the molar ratio of 1:1, and 100 μL of the resulting solution is added to 10 mL of a mixed aqueous solution containing 10 mM cetyltrimethylammonium chloride and 0.5 mM potassium iodide , shake gently; then add 100μL 60mM ascorbic acid to the obtained solution, shake gently until the solution becomes colorless, then add 5μL 0.05M sodium hydroxide, mix quickly; stand at room temperature for 0.5-1h, and then dissolve the product Centrifuge and wash at room temperature;
[0061](2) Transfer the product obtained in step (1) to water for dispersion, add 2 mL of the dispersion with an absorbance of 2.0 to a mixed solution containing 10 mL of 10 mM cetyltrimethylammonium bromide aqueous solution, 0.1 mL of ammonia water, and 1 mL of ethanol , add 0.1mL of 5wt% 1,4-bis(triethoxysilyl)...
Embodiment 3
[0067] (1) Preparation of aromatic mesoporous organic silica layer-wrapped gold nanotriangular sheets
[0068] (1) 30mM chloroauric acid solution is mixed with 0.2M sodium hydroxide solution at a molar ratio of 1:1, and 100 μL of the resulting solution is added to 10 mL of a mixed aqueous solution containing 10 mM cetyltrimethylammonium chloride and 1 mM potassium iodide, Shake gently; then add 100μL 100mM ascorbic acid to the resulting solution, shake gently until the solution becomes colorless, then add 5μL 0.2M sodium hydroxide, mix quickly; let stand at room temperature for 0.5-1h, and then put the product in Centrifuge and wash at room temperature;
[0069] (2) Transfer the product obtained in step (1) to water for dispersion, add 2 mL of the dispersion with an absorbance of 4.0 to a mixed solution containing 10 mL of 10 mM cetyltrimethylammonium chloride aqueous solution, 0.1 mL of ammonia water, and 10 mL of ethanol 0.1 mL of 10 wt% 1,4-bis(triethoxysilyl)phenethyl alc...
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