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A kind of pericardial collagen composite material and its preparation method and application
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A composite material and pericardial technology, applied in prosthetics, tissue regeneration, medical science, etc., can solve problems such as osteoinductive and bionic bone structures are not ideal
Active Publication Date: 2020-07-07
SHANDONG UNIV
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Artificial bone materials have been formed rapidly in recent years, and can better synthesize bone repair substitute materials that are close to the shape of defective bone, but their osteoinductive and biomimetic bone structures are not ideal enough
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Embodiment 1
[0026] This embodiment provides a polysaccharide-containing pericardial composite material, which is prepared by the following steps:
[0027] 1. Remove the fat from the pericardium purchased in the market with a glass plate or steel plate, and freeze it in the refrigerator for 24 hours;
[0028] 2. Put the fat-removed pericardium into a beaker and rinse it with deionized water for 3 times, each time for 5 minutes. At this time, if there is any fat tissue, remove it sharply with scissors and tweezers;
[0029] 3. Degreasing: the ratio of solid to liquid is 3:1, the temperature is 40°C, add a degreasing agent with a weight ratio of 0.6% of pig pericardium, and act for 1.5h. The ratio of solid to liquid is 4:1, washed twice with water;
[0030] 4. Alkali treatment: the ratio of solid to liquid is 3:1, the temperature is 28°C, add sodiumhydroxide with a mass ratio of 0.8% of pig pericardium, and 0.6% degreasing agent, turn for 30 minutes, turn for 10 minutes every 50 minutes, a...
Embodiment 2
[0042] This embodiment provides a pericardial composite material containing bone substitute material or growth factor, which is prepared by the following steps:
[0043] Operate according to example 1
[0044] 7. Compounding: liquid ratio 2.5:1, temperature 35°C, pH value 6.4-6.8, hydroxyapatite 2.0%, react for 90 minutes, wash with PBS;
[0045] 8. Cross-linking: liquid ratio 2.0:1, temperature 30°C, glutaraldehyde 0.2%, add in portions, adjust the pH value to 8, react for 60 minutes, wash with water until the pH value is neutral;
[0046] 9. Washing with PBS: liquid ratio 3:1, temperature 25°C, wash 3 times.
[0048] The pericardial collagen composite material prepared by the above method can be used as a bone repair material.
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technical field [0001] The invention relates to the fields of chemical engineering, bioengineering, medicine and material science, and in particular to a pericardial collagen composite material and its preparation method and application. Background technique [0002] Guided bone regeneration membranes are divided into two categories: non-absorbable membranes and absorbable membranes. Non-absorbable membranes include polytetrafluoroethylene (expanded polytetrafluoroethylene, e-PTFE) and titanium-enhanced polytetrafluoroethylene (Ti-e-PTFE) membranes. , peptide film, these polymer materials have good physical, chemical, thermal and mechanical properties, but due to their inertness, they cannot be degraded in the body, and patients need to undergo a second operation to remove them, which will cause additional surgical costs and pain, and prolong the life of the patient. the patient's healing cycle. Absorbable membranes overcome this shortcoming and are widely used. However, cu...
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