Application of tofacitinib citrate in the treatment of Takayasu arteritis

Abstract

The invention discloses an application method of tofacitinib citrate in the medical field. The specific implementation method is that drug administration per oral is carried out to treat the multiple arteritis. Clinical experimental study indicates that the tofacitinib citrate can be given to a multiple arteritis patient to obviously relieve symptoms including limb intermittent dyskinesia, aorta and branch or limb proximal aortic stenosis or occlusion and the like, laboratory index C reactive protein is obviously lowered, the relapse risk of diseases can be lowered, and the living quality of the patient is improved.

Description

technical field [0001] The invention relates to an application of tofacitinib citrate in medicine for treating Takayasu arteritis. Background technique [0002] Takayasuarteritis (TA), also known as Kawasaki disease, is a chronic inflammatory disease of unknown etiology, mainly involving the aorta and its main branches, and the pulmonary artery can also be involved. The disease is more common in women of childbearing age, but also in men and other age groups. Clinical manifestations mainly include nonspecific systemic symptoms and characteristic ischemic symptoms. Systemic symptoms mainly include fever, arthralgia, night sweats, weight loss, etc.; ischemic symptoms are mainly related to the scope and severity of blood vessels involved, including intermittent claudication, weak pulse, angina, vision loss, and stroke. The disease is a worldwide disease, and the incidence rate in East Asia, South Asia, and Latin America is higher than other regions, and the annual incidence r...

AI Technical Summary

Problems solved by technology

There are few clinical reports on the use of this type of drug. Although it has a certain effect in the treatment of patients with recurrent and refractory Takayasu arteritis, the application effect in mild to moderate patients is not clear.

In addition, there are methods such as interventional therapy and surgical treatment, but they also have disadvantages such as high cost, high risk, and unsatisfactory long-term effect.