Aromatic hydrocarbon ruthenium complex and preparation method and applications thereof

A technology of ruthenium complexes and aromatic hydrocarbons, applied in the directions of ruthenium organic compounds, platinum group organic compounds, chemical instruments and methods, etc.

Inactive Publication Date: 2017-07-14
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of compound has good activity against A2780 human ovarian cancer in vitro, but has no cross-resistance

Method used

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  • Aromatic hydrocarbon ruthenium complex and preparation method and applications thereof
  • Aromatic hydrocarbon ruthenium complex and preparation method and applications thereof
  • Aromatic hydrocarbon ruthenium complex and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Microwave Synthesis of RAM01

[0061] by RuCl 3 Reaction with 1-methyl-1,4-cyclohexadiene at 30-180°C, microwave irradiation for 15s-60min to obtain the intermediate, the intermediate obtained by the above reaction and imidazol[4,5f][1,10]phenanthrene Roline (IP) was irradiated with microwave for 15s at 60°C in dichloromethane solvent. After the reaction, it was dissolved with a small amount of methanol to obtain RAM01, whose structural formula is as follows.

[0062]

Embodiment 2

[0064] Microwave Synthesis of RAM09

[0065] The foregoing steps are the same as in Example 1;

[0066] The intermediate and 2-phenyl-imidazo[4,5f][1,10]phenanthroline (PIP) were irradiated with microwaves at 120°C for 30 minutes in dichloromethane solvent to obtain RAM09 with the following structural formula.

[0067]

Embodiment 3

[0069] Microwave synthesis of RAM031

[0070] The foregoing steps are the same as in Example 1;

[0071] The intermediate and 2-(2-fluorophenyl)-imidazol[4,5f][1,10]phenanthroline (PIP) were irradiated by microwave at 90°C for 30min in dichloromethane solvent.

[0072]

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PUM

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Abstract

The invention discloses an aromatic hydrocarbon ruthenium complex and an application thereof as an antitumor drug. For the aromatic hydrocarbon ruthenium complex, methyl benzene is taken as a ligand, phenanthro-imidazole and derivatives of phenanthro-imidazole are taken as the second ligand, and a chlorine atom is taken as the third ligand. The complex can inhibit the propagation, invasion and metastasis of tumor cells, has an especially good effect on inhibiting growth of cells of breast cancer, brain glioma, leukemia, nasopharyngeal carcinoma, and pulmonary adenocarcinoma, and barely damages the normal cells of human body. The invention also discloses a preparation and applications of the aromatic hydrocarbon ruthenium complex.

Description

technical field [0001] The invention relates to the technical field of synthetic chemistry, in particular to an arene ruthenium complex, and also relates to a preparation method and application of the arene ruthenium complex. Background technique [0002] The arene ruthenium complex has a classic "piano bench" spatial structure, and is a small covalent bond with the central metal ruthenium through electrons on the π orbital on the benzene ring, which use strongly hydrophobic benzene or substituted benzene as an auxiliary ligand. Molecular organometallic compounds. Since Winkhaus and Singer first synthesized arene ruthenium (II) compounds in 1967 [1], there have been a large number of literatures at home and abroad reporting the synthesis and antitumor effects of various types of arene ruthenium complexes. [0003] Kondapi et al. reported that [(η 6 -C 6 h 6 )Ru(DMSO)Cl 2 ] 2 + The representative aromatic hydrocarbon ruthenium complex exhibits good inhibitory effects o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F15/00C07D401/14A61P35/00A61P35/04
CPCC07F15/0046C07D401/14
Inventor 汪保国吴琼梅文杰蓝宇涛王涛
Owner GUANGDONG PHARMA UNIV
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