Targeted gene next-generation sequencing data automatic analysis system and method

A data analysis and next-generation sequencing technology, applied in the direction of electrical digital data processing, special data processing applications, instruments, etc., can solve the problems of manual operation and inapplicability of large-scale automatic analysis of data, etc., to achieve easy management and save manpower Cost, the effect of reducing the probability of error

Active Publication Date: 2018-06-26
上海序祯达生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] One of the technical problems to be solved by the present invention is to provide an automatic analysis system for targeted gene next-generation sequencing data, which overcomes the shortcomings of the prior art that there are many manual operations and is not suitable for automatic analysis of large-scale data

Method used

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  • Targeted gene next-generation sequencing data automatic analysis system and method
  • Targeted gene next-generation sequencing data automatic analysis system and method
  • Targeted gene next-generation sequencing data automatic analysis system and method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0115] Example 1 Cloud automated analysis of targeted gene sequencing data

[0116] 1. Put the sequencing data of sample 1 in the designated location according to the requirements.

[0117] 2. The system automatically detects the sample 1 to be analyzed.

[0118] 3. Upload the data to the cloud.

[0119] 4. The data is uploaded successfully, and cloud data analysis is started.

[0120] 5. Monitor the status of cloud data analysis and the analysis is successful.

[0121] 6. After passing the quality inspection, the data is placed in the analysis result storage unit.

Embodiment 2

[0122] Example 2 Local automated analysis of targeted gene sequencing data

[0123] 1. Put the sequencing data of sample 2 in the designated location as required.

[0124] 2. The system automatically detects the sample to be analyzed 2.

[0125] 3. Upload the data to the cloud.

[0126] 4. Data upload failed, copy the data to the local server.

[0127] 5. Start local data analysis.

[0128] 6. Monitor the local data analysis status, and the analysis is successful.

[0129] If the quality inspection is passed, the data is placed in the analysis result storage unit.

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Abstract

The invention discloses an automated analysis system for targeted gene next-generation sequencing data. The automated analysis system comprises a to-be-analyzed data storage unit, an analysis way decision unit, a cloud data analysis unit, a backup data analysis unit and an analysis result storage unit, wherein the to-be-analyzed data storage unit is used for storing to-be-analyzed data, and if the unit has the data, the analysis way decision unit is entered; the analysis way decision unit is used for deciding data analysis ways, and the cloud data analysis unit or the backup data analysis unit is independently entered; the cloud data analysis unit carries out data analysis on the to-be-analyzed data uploaded to the cloud by taking a sample as a unit; the backup data analysis unit carries out data analysis on a local analysis platform; and the analysis result storage unit is used for storing an analysis result of quality detection qualified data from the cloud data analysis unit and the backup data analysis unit. By use of the system, the problem in the prior art that more manual operations are not suitable for the full automatic analysis of large-scale data is solved, and a cloud and local calculation double-platform automatic switching strategy is adopted to guarantee the robustness of automated analysis.

Description

technical field [0001] The invention belongs to the field of biomedical detection, and relates to the detection of single nucleotide variation (SNV, SingleNucleotide Variant) and segment insertion-deletion (InDel, Short Insertion-Deletion) of next-generation sequencing data, specifically for the detection of next-generation sequencing data of targeted genes An automated analysis system and method for SNV and InDel detection. Background technique [0002] The core idea of ​​next-generation gene sequencing technology is sequencing while synthesizing. Four different deoxyribonucleic acid A, T, C, G are labeled with fluorescent colors of different colors, and deoxyribonucleotides are added sequentially when synthesizing the complementary strand of the gene template by polymerase chain reaction (PCR, Polymerase Chain Reaction). To the end of the complementary strand, the added deoxyribonucleotide species are identified by capturing the fluorescent signal at the end, thereby dete...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G06F19/20
CPCG16B25/00
Inventor 孟鑫祝鹏飞彭建龙戴珩
Owner 上海序祯达生物科技有限公司
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