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Process for extracting maackiain from radix millettiae speciosae

A technology of sophorin and Niu Dali, which is applied in the direction of organic chemistry, can solve the problems of failing to meet the requirements of qualitative and quantitative reference substances and low purity of sophorin

Inactive Publication Date: 2017-07-21
南宁馨艺荣生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention provides a process for extracting sophorin from Niu Dali to solve the problem that the purity of sophorin extracted and purified from Niu Dali is low and cannot meet the requirements of qualitative and quantitative reference substances

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A process for extracting sophorin from Niu Dali, comprising the following steps:

[0037] S1: Pulverize Niu Dali and pass through a 50-mesh sieve to obtain Niu Dali powder;

[0038] S2: Add 76% ethanol 7 times its weight to the Niu Dali powder prepared in step S1, and extract twice under ultrasonic reflux under the condition of water bath, the frequency of each ultrasonic wave is 780W, the temperature is 44°C, and the time is 10min. After completion, combine the extracts, adjust the pH value of the extracts to 4.5, control the temperature at 46°C, decolorize and remove impurities by activated carbon for 1.2 hours, and obtain a decolorized solution after filtration;

[0039] S3: Concentrate and dry the primary decolorization solution obtained in step S2 to obtain an extract extract, which is dissolved in water at 50° C. with 5.6 times the volume of the extract extract, extracted twice with anhydrous ethyl acetate solvent, and continued to use Anhydrous ethyl acetate was...

Embodiment 2

[0044] A process for extracting sophorin from Niu Dali, comprising the following steps:

[0045] S1: Pulverize Niu Dali and pass through a 40-mesh sieve to obtain Niu Dali powder;

[0046] S2: Add 6 times the weight of 70% ethanol to the Niu Dali powder prepared in step S1, and extract twice by ultrasonic reflux under water bath conditions, the frequency of each ultrasonic wave is 750W, the temperature is 40°C, and the time is 11min. After completion, combine the extracts, adjust the pH value of the extracts to 4.4, control the temperature at 42°C, decolorize and remove impurities by activated carbon for 1.4 hours, and obtain a decolorized solution after filtration;

[0047] S3: Concentrate and dry the primary decolorization solution obtained in step S2 to obtain an extract extract, which is dissolved in water at 48°C with 5.2 times the volume of the extract extract, extracted twice with anhydrous ethyl acetate solvent, and continued to use Anhydrous ethyl acetate is carried ...

Embodiment 3

[0052] A process for extracting sophorin from Niu Dali, comprising the following steps:

[0053] S1: Pulverize Niu Dali and pass through a 60-mesh sieve to obtain Niu Dali powder;

[0054] S2: Add 80% ethanol 8 times its weight to the Niu Dali powder prepared in step S1, and extract 3 times under ultrasonic reflux under the condition of water bath, the frequency of each ultrasonic wave is 820W, the temperature is 46°C, and the time is 8min. After completion, combine the extracts, adjust the pH value of the extracts to 4.6, control the temperature at 50°C, decolorize and remove impurities by activated carbon for 0.7h, and obtain a decolorized solution after filtration;

[0055] S3: Concentrate and dry the primary decolorization solution obtained in step S2 to obtain an extract extract, which is dissolved in water at 52°C with 6 times the volume of the extract extract, extracted 3 times with anhydrous ethyl acetate solvent, and continued to use Anhydrous ethyl acetate was cryst...

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PUM

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Abstract

The invention discloses a process for extracting maackiain from radix millettiae speciosae, and belongs to the technical field of extracting active ingredients from radix millettiae speciosae. The maackiain is prepared by crushing, primary decolorization, crude crystallization, secondary decolorization, separation by macroporous adsorption resin for purification, concentrated crystallization, drying and other steps. The maackiain obtained with the method disclosed by the invention has the extraction rate being equal to or higher than 62.05 and the purity being equal to or higher than 98.34%, and the purity meets a requirement of the purity of a qualitative and quantitative reference substance.

Description

[0001] 【Technical field】 [0002] The invention belongs to the technical field of extracting active ingredients from Niu Dali, in particular to a process for extracting sophorin from Niu Dali. [0003] 【Background technique】 [0004] Niu Dali is the root of the beautiful Yadou vine of the genus Fabaceae, commonly known as mountain lotus root, blood rattan, Jiulong string of beads, Niugu Dali, and Dali potato. It is flat in nature and sweet in taste, has the effects of tonifying deficiency and moistening lungs, strengthening tendons and activating collaterals. It has been clinically proven to have certain curative effects on lumbar muscle strain, rheumatoid arthritis, tuberculosis, and chronic bronchitis. It is widely used as a raw material for soup in Guangxi, which can nourish the waist and kidneys and strengthen the bones. It is a famous medicinal and edible plant in the Lingnan area. The main ingredients in the bovine herbal medicine are formononetin and sophorin. In the p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/14
CPCC07D493/14
Inventor 梁可文黄能谢冬养
Owner 南宁馨艺荣生物科技有限公司