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Traditional Chinese medicine composition and application thereof to preparation of drugs for treating pulmonary fibrosis diseases

A composition and technology of traditional Chinese medicine, applied in the field of medicine, can solve the problem that it is difficult for medicine to achieve effective treatment

Active Publication Date: 2017-07-25
BINZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The pathogenesis of pulmonary fibrosis is complexly regulated by multiple factors, and it is difficult to achieve effective treatment with a single-target drug. Therefore, people began to pay more attention to multi-component, multi-target traditional Chinese medicine.

Method used

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  • Traditional Chinese medicine composition and application thereof to preparation of drugs for treating pulmonary fibrosis diseases
  • Traditional Chinese medicine composition and application thereof to preparation of drugs for treating pulmonary fibrosis diseases
  • Traditional Chinese medicine composition and application thereof to preparation of drugs for treating pulmonary fibrosis diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1. The preparation of Chinese medicine composition oral liquid

[0029] Take 300g of Astragalus, 200g of Codonopsis, 100g of Ophiopogon japonicus, 100g of Schisandra chinensis, 50g of Panax notoginseng, 100g of Zhebei, 100g of Anemarrhena, 50g of roasted licorice, the above eight flavors, add 20 liters of water, decoct twice, 2 hours each time, combine The decoction is concentrated to 10 liters, left to stand overnight, filtered, and the filtrate is added with 5% white granulated sugar and 0.01% potassium sorbate, filled and sterilized to obtain the product. Each bottle is equivalent to 10g of raw medicinal materials.

Embodiment 2

[0030] Embodiment 2. The preparation of Chinese medicine composition ointment

[0031] Take 300g Sun-roasted Astragalus, 180g Codonopsis, 120g Ophiopogon japonicus, 90g Southern Schisandra, 60g Panax notoginseng, 60g Zhebei, 60g Anemarrhena, 30g Zhigancao, the above eight flavors, add 20 liters of water, decoct twice, 2 hours each time, Combine the decoction liquid, concentrate to 10 liters, stand overnight, filter, and further concentrate the filtrate to a clear paste (density 1.1-1.5), add 5% white sugar and 0.01% potassium sorbate, fill and sterilize, to obtain . Each ml of extract is equivalent to 1g of the original medicinal material.

Embodiment 3

[0032] Embodiment 3. The preparation of Chinese medicine composition granule

[0033] Take 250g Astragalus, 200g Codonopsis, 150g Ophiopogon japonicus, 100g Southern Schisandra, 100g Panax notoginseng, 100g Chuanbei, 100g Anemarrhena, 50g roasted licorice, the above eight flavors, add 20 liters of water, decoct twice, 2 hours each time, combine After the decoction is concentrated to a clear paste, powdered sugar is added as an auxiliary material at a ratio of 1:1, mixed evenly, granulated, dried and packaged to obtain the product. Each bag is equivalent to 10g of raw medicinal materials.

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PUM

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Abstract

The invention relates to a constitution and preparing method of a traditional Chinese medicine composition and application thereof to preparation of drugs for treating pulmonary fibrosis diseases. The composition is composed of radix astragali, radix codonopsis, radix ophiopogonis, fructus schizandrae, radix notoginseng, thunberg fritillary bulb, rhizoma anemarrhenae and licorice roots. The composition can regulate the expression of short-chain non-coding RNA (miRNAs) and long-chain non-coding RNA (incRNA), and can protect alveolar epithelial cells and interfere with the activity of myofibroblasts, so that the process of pulmonary fibrosis can be inhibited. Therefore, the composition is expected to be well applied to preparation of drugs for treating pulmonary fibrosis diseases.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a traditional Chinese medicine composition and its application in preparing medicine for treating pulmonary fibrosis. Background technique [0002] Pulmonary fibrosis (PF) is a group of pulmonary interstitial diseases of unknown etiology, with progressively aggravated dyspnea as the most prominent clinical manifestation, and the main pathological features are alveolar epithelial cell damage, fibroblast activation, fibroblast Foci formation and excessive deposition of extracellular matrix eventually lead to abnormal remodeling of lung tissue architecture. The current treatment drugs are mainly corticosteroids, immunosuppressants, anti-inflammatory drugs, and cytotoxic drugs, but most patients are not sensitive to drugs, the disease progresses rapidly, and the mortality rate is high. Treatment is still an international problem. In the study of anti-pulmonary fibrosis ...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61P11/00
CPCA61K9/0053A61K9/06A61K9/08A61K9/1623A61K9/2018A61K9/2031A61K9/4858A61K36/258A61K36/344A61K36/481A61K36/484A61K36/57A61K36/79A61K36/8964A61K36/8966A61K36/8968A61K47/26A61K2300/00
Inventor 吕长俊刘玉霞刘博宋晓冬王友磊张瑾锦曲桂武
Owner BINZHOU MEDICAL COLLEGE
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