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Method for characterisation of perivascular tissue

A technology for surrounding tissues and blood vessels, applied in cardiac catheterization, application, echo tomography, etc., can solve the problems of not characterization of PVAT, differentiation, etc.

Active Publication Date: 2017-08-01
OXFORD UNIV INNOVATION LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Available techniques provide information on the amount of perivascular PVAT, but this data does not characterize measured PVAT and it cannot be differentiated between lesions

Method used

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  • Method for characterisation of perivascular tissue
  • Method for characterisation of perivascular tissue
  • Method for characterisation of perivascular tissue

Examples

Experimental program
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Effect test

Embodiment 1

[0080] Available computed tomography (CT) images from a 64-slice scanner (General Electric, LightSpeed ​​Ultra, General Electric, Milwaukee, WI, USA) were used to analyze perivascular tissue and vascular disease tables. type. Adjust the acquisition environment according to the local clinical protocol to achieve optimal image quality. The reconstructed contrast-enhanced images were transferred to Aquarius from TeraRecon, Inc. (San Mateo, CA V.4.4.11) Used to perform volumetric reconstruction analysis. Use 3D curved multiplanar reconstruction to define vessel segments of interest and analyze perivascular tissue. The reader needs to manually trace the region of interest and the perivascular tissue is then segmented into concentric layers around the outer vessel wall in a semi-automatic fashion. Perivascular tissue characteristics were analyzed to determine radiodensity values ​​corresponding to voxels of adipose tissue or water in each pericardiovascular layer within the firs...

Embodiment 2

[0082] research group

[0083]Study arm 1 consisted of 453 patients undergoing cardiac surgery at Oxford University Hospitals NHS Foundation Trust (see Table 1). Exclusion criteria were any inflammatory, infectious, liver / renal disease or malignancy. Patients receiving non-steroidal anti-inflammatory drugs were also excluded. During surgery, samples of adipose tissue were harvested, subcutaneous (ScAT, from the chest incision site), thoracic (ThAT, from the central thoracic area, attached to the pericardium) and epicardial adipose tissue (EpAT, from the right atrioventricular groove site, away from visible blood vessels). Adipose tissue samples were snap frozen for gene expression studies, histology, and CT imaging as explants, as described below. A subgroup of 105 of these patients also underwent CT angiography (CTA), as described below, with the goal of correlating the histological and biological characteristics of the adipose tissue biopsy with the image characteristics ...

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Abstract

The present invention defines methods for volumetric characterisation of perivascular adipose tissue using data collected by computed tomography (CT) scanning. The volumetric characterisation of perivascular adipose tissue allows the inflammatory status of underlying blood vessels to be established by CT scanning. This is of use in the diagnosis, prognosis and treatment of coronary and vascular disease..

Description

[0001] field of invention [0002] The present invention relates to perivascular tissue and methods for its characterization. Background technique [0003] Perivascular adipose tissue (PVAT) surrounds (coronary) arteries and may participate in the local stimulation of atherosclerotic plaque formation. PVAT can be quantified using a variety of techniques including, for example, echocardiography, computed tomography (CT), and magnetic resonance imaging (MRI). The amount of PVAT correlates with several parameters of the metabolic syndrome, including increased waist circumference, hypertriglyceridemia and hyperglycemia, and coronary atherosclerosis. PVAT has long been known to secrete pro-inflammatory proteins and induce inflammation of arterial walls. The long-standing understanding of the pathology of atherosclerosis in the vessel wall is that it is externally stimulated, and PVAT was proposed to play a key role in this process. [0004] Atherosclerosis is a progressive proce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B6/00
CPCA61B6/032A61B6/504A61B6/5217G16H50/30
Inventor C·安东尼亚德斯
Owner OXFORD UNIV INNOVATION LTD
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