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Pochoxime conjugates useful for the treatment of HSP90 related pathologies

A compound, CH2 technology, used in drug combinations, skin diseases, sugar derivatives, etc., can solve problems such as no pharmacological properties

Inactive Publication Date: 2017-08-04
UNIVERSITY OF STRASBOURG +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, neither of these two natural products possess acceptable pharmacological properties for clinical applications

Method used

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  • Pochoxime conjugates useful for the treatment of HSP90 related pathologies
  • Pochoxime conjugates useful for the treatment of HSP90 related pathologies
  • Pochoxime conjugates useful for the treatment of HSP90 related pathologies

Examples

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Embodiment Construction

[0032] The present invention provides pochoxime derivatives as described herein. In one embodiment, the compounds of the present invention have the structural formula (I), (II), (IIIa), (IIIb) and (IIIc), and any subgenus and species thereof, wherein the targeting moiety is linked to the allylic Carbon 6 connection. Specifically, allylic carbon 6 refers to the carbon atom (marked with *) covalently attached to "L", as shown below in structural formula (I):

[0033]

[0034] Wherein the respective substituents are as defined in the above "Summary of the Invention".

[0035] The term "targeting moiety" as used herein may be a moiety of a molecule that specifically binds to a biological site under physiological conditions. For example, a targeting moiety can bind to a defined cell population or to a selected cell type. A targeting moiety can also bind a receptor, oligonucleotide, enzyme substrate, antigenic determinant, or other binding site present on or in a target cell o...

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Abstract

The present invention includes novel derivatives, analogs, and intermediates of the natural products radicicol, pochonins, pochoximes, and their syntheses. The present invention also provides a pharamceutical composition comprising the present compound and the use of the compound as inhibitors of kinases and of the enzyme family known as heat shock protein 90 (HSP90).

Description

[0001] This application is a Chinese invention patent application (application date: October 24, 2011; application number: 201180060183.0 (international application number: PCT / IB2011 / 002796); invention name: Pochoxime conjugates for the treatment of HSP90-related conditions) Divisional application. [0002] Cross References to Related Applications [0003] This application claims priority to U.S. Provisional Application 61 / 405,882, filed October 22, 2010, and entitled "POCHOXIME CONJUGATES USEFULFOR THE TREATMENT OF HSP90RELATED PATHOLOGIES," the entire disclosure of 61 / 405,882 is incorporated herein by reference for all purposes All purposes. This application is also related to International Application PCT / US2007 / 017754, filed August 10, 2007 and entitled "Macrocyclic Compounds Useful as Inhibitors of Kinase and HSP90"; and filed January 15, 2009 and entitled "Synthesis of Resorcylic Acid Lactones Useful as Therapeutic Agents", International Application PCT / US2009 / 031149, t...

Claims

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Application Information

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IPC IPC(8): C07D313/00C07H17/08C07D495/04A61K31/335A61K31/7048A61K31/4188A61P37/00A61P29/00A61P25/00A61P35/00A61P9/00A61P11/06A61P5/00
CPCC07D313/00C07D495/04C07H17/08C07H15/26A61K31/4523A61K31/454A61K31/706C07D405/12C07D405/14A61P11/06A61P17/02A61P17/06A61P19/02A61P19/06A61P25/00A61P27/02A61P27/06A61P29/00A61P35/00A61P35/02A61P37/00A61P37/02A61P37/06A61P37/08A61P43/00A61P5/00A61P9/00A61P9/10A61K31/4427
Inventor N.温辛格S.巴鲁恩嘉
Owner UNIVERSITY OF STRASBOURG
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