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A kind of protoporphyrin fluorescent carbon dot and its preparation method and application

A technology of fluorescent carbon dots and protoporphyrin, applied in botany equipment and methods, applications, chemical instruments and methods, etc., to achieve the effects of low risk, good water solubility, and mild reaction conditions

Active Publication Date: 2019-04-26
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of this, the object of the present invention is to overcome the shortcoming that protoporphyrin is insoluble in water, obtain a kind of water-soluble protoporphyrin fluorescent carbon point, and propose a kind of preparation method and application of protoporphyrin fluorescent carbon point

Method used

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  • A kind of protoporphyrin fluorescent carbon dot and its preparation method and application
  • A kind of protoporphyrin fluorescent carbon dot and its preparation method and application
  • A kind of protoporphyrin fluorescent carbon dot and its preparation method and application

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Embodiment 1

[0026] The preparation method of protoporphyrin fluorescent carbon dot 1 comprises the following steps:

[0027] 1) Mix 10mL of 2mg / mL PEI (Mn=550~650) solution, weigh 10mg of protoporphyrin, add them together into the hydrothermal reaction kettle, and react at 220°C for 10h;

[0028] 2) After the reaction is completed, cool to room temperature, and perform dialysis with a 1000D dialysis bag for 3 days, and then filter the dialysis product with a 0.22 μm pinhole filter, and the obtained filtrate is protoporphyrin fluorescent carbon dots.

Embodiment 2

[0030] The preparation method of protoporphyrin fluorescent carbon dot 2 comprises the following steps:

[0031] 1) Mix 10mL of 2mg / mL PEI (Mn=550~650) solution, weigh 10mg of protoporphyrin, add them together into the hydrothermal reaction kettle, and react at 220°C for 8h;

[0032] 2) After the reaction is completed, cool to room temperature, and perform dialysis with a 1000D dialysis bag for 3 days, and then filter the dialysis product with a 0.22 μm pinhole filter, and the obtained filtrate is protoporphyrin fluorescent carbon dots.

Embodiment 3

[0034] The preparation method of protoporphyrin fluorescent carbon dot 3 comprises the following steps:

[0035] 1) Mix 10mL of 2mg / mL PEI (Mn=550~650) solution, weigh 10mg of protoporphyrin, add them together into the hydrothermal reaction kettle, and react at 180°C for 8h;

[0036] 2) After the reaction is completed, cool to room temperature, and perform dialysis with a 1000D dialysis bag for 3 days, and then filter the dialysis product with a 0.22 μm pinhole filter, and the obtained filtrate is protoporphyrin fluorescent carbon dots.

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Abstract

The invention relates to a protoporphyrin fluorescent carbon dot, and a preparation method and application thereof. The preparation method comprises the following concrete steps: reacting protoporphyrin with polyethyleneimine (PEI) at 170 to 220 DEG C for 7 to 10 h; and then successively carrying out cooling, dialysis and filtering so as to obtain the protoporphyrin fluorescent carbon dot. The protoporphyrin fluorescent carbon dot prepared in the invention has good water solubility and maintains the intact properties of protoporphyrin; photodynamic effect produced by a porphyrin photosensitizer can effectively inactivate yeast cells, so bactericidal effect is exerted; and the preparation method has the advantages of simple reaction steps, mild reaction conditions, small danger, low toxicity, etc.

Description

technical field [0001] The invention belongs to the technical field of polymer material synthesis and preparation, and relates to a protoporphyrin fluorescent carbon point and a preparation method thereof. Background technique [0002] In recent years, due to the abuse of antibiotics has led to the emergence and spread of "super bacteria". The so-called "super bacteria" means that these bacteria have multi-drug resistance to current antibiotics, which adds great difficulty to the treatment of clinical wound infections. Therefore, the development of new anti-infection strategies is imminent. Photodynamic antimicrobial therapy is one of the most promising new therapies, which has shown good curative effect on infections caused by bacteria, fungi and viruses, especially for drug-resistant bacterial infections. [0003] Protoporphyrin is a well-known aromatic macrocyclic compound widely present in nature. Protoporphyrin is purple-brown crystalline powder, easily soluble in me...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G73/02C09K11/06A01N43/90A01P1/00A01P3/00
CPCA01N43/90C08G73/0213C09K11/06C09K2211/1466
Inventor 徐立群宁玲贵蔡晓燕
Owner SOUTHWEST UNIV
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