A kind of absorbable chitin-based composite patch and its application

A chitin and patch technology, used in prostheses, surgery, coatings, etc., can solve the problems of degradation time and mechanical strength and abdominal wall defects, body tissue growth and repair, and hernia repair rates. Epithelial cell growth, promotion of fibroblast growth, and reduction of intraperitoneal adhesions

Active Publication Date: 2020-08-07
青岛健康海洋生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the long-term existence of non-degradable materials such as polypropylene, there are still problems such as sterile inflammation caused by physical stimulation, and at the same time, it does not match the growth and repair of body tissues.
Therefore, research on degradable surgical mesh has received extensive attention, such as biogenic acellular matrix mesh, but biogenic mesh often degrades quickly, has low mechanical strength, and may even produce immunogenic reactions. The degradation time and mechanical The strength does not match the speed of abdominal wall defect and hernia repair, so there is no ideal patch for the treatment of abdominal wall defect

Method used

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  • A kind of absorbable chitin-based composite patch and its application
  • A kind of absorbable chitin-based composite patch and its application
  • A kind of absorbable chitin-based composite patch and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: Water Solubility Test of Chitin-based Fibers Containing Different Acylation Groups and Hydrophilic Groups

[0016] Chitin-based fibers with different acylation group contents and hydrophilic group contents were purchased from Qingdao Shunbo Biotechnology Research Institute. The water solubility of these different chitin-based fibers was tested through experiments, and the results are shown in Table 1. It can be seen from Table 1 that when the molar percentage of the acyl group of the chitin-based fiber is greater than or equal to 68.5%, and the molar percentage of the hydrophilic group is less than or equal to 30.9%, the chitin-based Fiber does not dissolve in water.

[0017] Table 1. Comparison of water solubility of chitin-based fibers

[0018]

Embodiment 2

[0019] Embodiment 2: the mechanical strength comparison of chitin-based fiber and chitosan fiber

[0020] Cut out 5 pieces of chitin-based fiber 3 (containing 68.5% acetyl group) and chitin-based fiber 5 (containing 73.8% propionyl group and 10.3% hydroxypropyl group) with a length of 10 cm of equivalent weight, and cut 5 pieces of length Chitosan fiber (purchased from Qingdao Shunbo Biotechnology Research Institute, containing 2.5% acetyl group) was 10cm, and the breaking strength of chitin-based fiber and chitosan fiber was tested on an electronic tensile machine. The measurement results show that the average breaking strength of chitin-based fiber 4 is 14.5N, the average breaking strength of chitin-based fiber 5 is 15.2N, and the average breaking strength of chitosan fiber is 10.3N, indicating that the breaking strength of chitin-based fiber Higher than the breaking strength of chitosan fiber. Further experiments show that when the mole percentage of hydrophilic groups is ...

Embodiment 3

[0022] Embodiment 3: Water-soluble aminoglycan promotes cell growth experiment

[0023] Using chondroitin sulfate (purchased from Qingdao Jiulong Biomedical Co., Ltd.), carboxymethyl chitin, and hydroxyethyl chitosan (purchased from Qingdao Honghai Biotechnology Co., Ltd.) as experimental materials, L929 fibroblasts were cultured in vitro and evaluated. Effects of 3 kinds of hydrophilic aminoglycans on cell generation. The L929 cells in the logarithmic growth phase were trypsinized, and the cell concentration was adjusted to 2.0×10 with DMEM medium. 4 cells / mL, seeded in 96-well cell culture plate, in CO 2 Incubator (37°C, 5% CO 2) after 24 hours of culture, the medium was changed, the culture wells without water-soluble aminoglycans were used as the control group, and the culture wells containing different concentrations of water-soluble aminoglycans (concentrations were 10, 50, 100, 250, 500 μg / mL) For the experimental group, the cell growth was observed after the cells w...

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Abstract

The invention discloses an absorbable chitin-based composite patch and an application thereof. The absorbable chitin-based composite patch is a mesh composed of chitin-based fibers or threads respectively having a surface coating; the chitin-based fibers or threads are insoluble in water, the main chain of the molecular structure of the chitin-based fibers or threads is polyglucosamine and contains an acyl group and a hydrophilic group, the total molar percent content of the acyl group is greater than or equal to 70%, and the total molar percent content of the hydrophilic group is less than 30%; and the surface coating is a water-soluble aminoglycan coating. The absorbable chitin-based composite patch is implanted in an abdominal wall in the operations of abdominal wall defect repairing and hernia repairing, can reduce the inflammatory response in the acute stage, reduce abdominal adhesions, promote the growth of the tissue cells and the synthesis of an extracellular matrix and accelerate the defect repairing of the abdominal walls in the physiologic repairing stage after the operation, and is gradually degraded after the abdominal wall defect repairing, and degradation products are absorbed and utilized by local tissue cells to further promote the abdominal wall defect repairing, so the absorbable chitin-based composite patch has no residual in bodies after being completely degraded, and no foreign matters exist in the bodies.

Description

technical field [0001] The invention relates to a biological patch, in particular to an absorbable chitin-based composite patch and its application, belonging to the field of biomedical materials. Background technique [0002] Hernia is a common disease in general surgery. It is mainly formed by organs or tissues together with the peritoneal wall, which protrudes from the abdominal wall defect or weak point to the body surface, such as inguinal hernia, incisional hernia, stoma hernia, etc., and generally cannot heal by itself. Tension-free hernia repair is the most widely used hernia treatment method in recent years. Open surgery or laparoscopic surgery is used to repair abdominal wall hernia. In the abdominal wall defect, and sutured fixed. Non-degradable synthetic polymer patches such as polypropylene patches and polyester patches commonly used at present are mesh structures woven from synthetic materials such as polypropylene fibers and polyester fibers, and have good te...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/20A61L27/34A61L27/58A61L31/04A61L31/10A61L31/14
CPCA61L27/20A61L27/34A61L27/58A61L31/042A61L31/10A61L31/148A61L2420/02A61L2430/00C08L5/08C08L5/00
Inventor 刘万顺
Owner 青岛健康海洋生物制药有限公司
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