Process for preparing 1-naphtylacetonitrile via potassium cyanide and 1-chloromethyl naphthalene

A technology of chloromethylnaphthalene and potassium cyanide, which is applied in the field of preparing 1-naphthaleneacetonitrile, can solve the problems of waste of resources, unsatisfactory homogeneity of 1-naphthaleneacetonitrile, and low success rate, so as to reduce adverse effects and improve preparation success rate, improve the effect of stability

Inactive Publication Date: 2017-08-11
枣阳市残联福利生物化工厂
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] 1-naphthaleneacetonitrile is an important intermediate for the synthesis of agomelatine. For this reason, the preparation of 1-naphthaleneacetonitrile has also attracted much attention. The existing preparation processes are directly synthesized, and the prepared 1-naphthalene Acetonitrile is not ideal in homogeneity, and the success rate of synthesis is not high, often causing unnecessary waste of resources

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The present invention proposes a kind of technique that prepares 1-naphthalene acetonitrile by potassium cyanide and 1-chloromethyl naphthalene, comprises the steps:

[0022] S1. Potassium cyanide, 1-chloromethylnaphthalene and protective agent are selected as the main raw materials, and the weight ratio of potassium cyanide and 1-chloromethylnaphthalene is 1:1.5, and the main raw materials are sealed and preserved;

[0023] S2. Potassium cyanide is placed in a heating container, and after the temperature of potassium cyanide is maintained at 40 degrees Celsius, it is moved to a constant temperature container;

[0024] S3, 1-chloromethylnaphthalene is placed in the heating container, and after the temperature of 1-chloromethylnaphthalene is maintained at 30 degrees Celsius, it is moved to a constant temperature container;

[0025] S4, the potassium cyanide treated in S2 is placed in the reactor, and the 1-chloromethylnaphthalene treated in S3 is slowly added dropwise to...

Embodiment 2

[0036] The present invention proposes a kind of technique that prepares 1-naphthalene acetonitrile by potassium cyanide and 1-chloromethyl naphthalene, comprises the steps:

[0037] S1. Potassium cyanide, 1-chloromethylnaphthalene and protective agent are selected as the main raw materials, and the weight ratio of potassium cyanide and 1-chloromethylnaphthalene is 1:1.5, and the main raw materials are sealed and preserved;

[0038] S2. Potassium cyanide is placed in a heating container, and after the temperature of potassium cyanide is maintained at 43 degrees Celsius, it is moved to a constant temperature container;

[0039] S3, 1-chloromethylnaphthalene is placed in the heating container, and after the temperature of 1-chloromethylnaphthalene is maintained at 32 degrees Celsius, it is moved to a constant temperature container;

[0040] S4, the potassium cyanide treated in S2 is placed in the reactor, and the 1-chloromethylnaphthalene treated in S3 is slowly added dropwise to...

Embodiment 3

[0051] The present invention proposes a kind of technique that prepares 1-naphthalene acetonitrile by potassium cyanide and 1-chloromethyl naphthalene, comprises the steps:

[0052] S1. Potassium cyanide, 1-chloromethylnaphthalene and protective agent are selected as the main raw materials, and the weight ratio of potassium cyanide and 1-chloromethylnaphthalene is 1:1.5, and the main raw materials are sealed and preserved;

[0053] S2. Potassium cyanide is placed in a heating container, and after the temperature of potassium cyanide is maintained at 47 degrees Celsius, it is moved to a constant temperature container;

[0054] S3, 1-chloromethylnaphthalene is placed in the heating container, and after the temperature of 1-chloromethylnaphthalene is maintained at 34 degrees Celsius, it is moved to a constant temperature container;

[0055] S4, the potassium cyanide treated in S2 is placed in the reactor, and the 1-chloromethylnaphthalene treated in S3 is slowly added dropwise to...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a process for preparing 1-naphtylacetonitrile via potassium cyanide and 1-chloromethyl naphthalene; the process comprises the steps of selecting potassium cyanide, 1-chloromethyl naphthalene, and a protectant as main materials, adding the treated potassium cyanide into a reactor, dropwise adding the treated 1-chloromethyl naphthalene slowly into the reactor holding the potassium cyanide, with the temperature of the reactor kept at 55-70 DEG C, mixing and stirring after dropwise adding, heating to 90-120 DEG C, adding a catalyst into the mixed solution, allowing reacting at 75-80 DEG C for 30-45 s, transferring into a drying device, drying at 200-240 DEG C, adding the protectant into the reacted liquid, concentrating the reacted liquid, crystallizing to obtain white powder, extracting the white powder, and recrystallizing to obtain 1-naphtylacetonitrile. The process has the advantages that preparation stability is effectively improved, the preparation method is reliable and the process is suitable for late large-batch production.

Description

technical field [0001] The invention relates to the technical field of chemical substance synthesis, in particular to a process for preparing 1-naphthaleneacetonitrile from potassium cyanide and 1-chloromethylnaphthalene. Background technique [0002] 1-naphthaleneacetonitrile is an important intermediate for the synthesis of agomelatine. For this reason, the preparation of 1-naphthaleneacetonitrile has also attracted much attention. The existing preparation processes are directly synthesized, and the prepared 1-naphthalene The homogeneity of acetonitrile is not ideal, and the success rate of synthesis is not high, often causing unnecessary waste of resources. Therefore, a process for preparing 1-naphthaleneacetonitrile from potassium cyanide and 1-chloromethylnaphthalene was proposed, and the existing preparation process was optimized. Contents of the invention [0003] The present invention proposes a process for preparing 1-naphthaleneacetonitrile by potassium cyanide ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07C253/14C07C255/33C07C17/263C07C22/04
CPCC07C253/14C07C17/263C07C255/33C07C22/04
Inventor 曹亮
Owner 枣阳市残联福利生物化工厂
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap