Double-echo based single-sweep quantitative magnetic resonance T2* imaging method

An imaging method, a single-scan technology, applied in the directions of magnetic resonance measurement, nuclear magnetic resonance imaging system for measurement, magnetic variable measurement, etc., can solve the problems of increasing time and signal attenuation, prolonging repetition time, and insufficient effect

Inactive Publication Date: 2017-08-15
XIAMEN UNIV
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Problems solved by technology

However, this method has limitations. One is that this method needs to prolong the echo chain, which will inevitably lead to increased acquisition time and signal attenuation; on the other hand, compared with the conventional EPI method, the realization of this method is to prolong the repetition time ( TR), which may require sacrificing the spatial res

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  • Double-echo based single-sweep quantitative magnetic resonance T2* imaging method

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Embodiment Construction

[0039] Below in conjunction with accompanying drawing and specific embodiment, the present invention will be further described:

[0040] Each step in the specific implementation process of the present invention is as follows:

[0041] (1) On the operating table of the magnetic resonance imager, open the corresponding operating software in the imager, first locate the region of interest of the imaging object, and then perform tuning, shimming, power and frequency correction;

[0042] (2) Import the pre-compiled T2*-OLED imaging sequence: according to the specific experimental situation, set the parameters of the pulse sequence;

[0043] The structure of the T2*-OLED sequence is as figure 1 In order: excitation pulse with flip angle α, pulse spacing δ TE (which includes the displacement gradient), the excitation pulse with flip angle α, the displacement gradient, and the sampling echo chain;

[0044] Two small-angle excitation pulses combined with two displacement gradients G...

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Abstract

A double-echo based single-sweep quantitative magnetic resonance T2* imaging method relates to magnetic resonance imaging. Two low-angle excitation pulses of the same deflection angle are used, an evolution period is added after the first excited pulse, two echoes of different evolution time are generated, the two echoes include different horizontal relaxation time, and a shift gradient is added after each excitation pulse so that two echo signals are offset in the center of a signal space. The two echo signals are from the same imaging slice, so that the two echo signals can be separated by utilizing prior knowledge including structural similarity and sparsity of combined edges of the signals, and a proper separation algorithm corresponding to sparse transformation cooperation can be used to separate the two echo signals. T2* calculation is carried out on the two signals obtained by separating to obtain a quantitative T2* image.

Description

technical field [0001] The invention relates to magnetic resonance imaging, in particular to a double-echo-based single-scan quantitative magnetic resonance T2* imaging method. Background technique [0002] T2* imaging, as a type of quantitative MRI imaging, provides a contrasting mechanism for analyzing normal and diseased living tissues in a non-invasive manner, and the iron content of tissues can be obtained through the measurement of T2* relaxation. [1,2] The measurement of T2* relaxation has been applied to functional magnetic resonance imaging (fMRI), such as the measurement of brain oxygen uptake and venous blood volume, and the diagnosis of brain diseases. [3,4] T2* imaging needs to obtain a series of contrast-weighted images, and T2* can be calculated only through two or more T2* weighted images with different echo times, which requires multiple scans to achieve. Multiple scans not only make T2* imaging vulnerable to motion, but also make the measurement time longe...

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Application Information

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IPC IPC(8): G01R33/54A61B5/055
CPCG01R33/54A61B5/055
Inventor 蔡聪波马崚嶒陈忠蔡淑惠丁兴号
Owner XIAMEN UNIV
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