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Application of isoliquiritigenin to preparation of drugs used for improving or treating exercise-induced fatigue, and pharmaceutical composition

A technology for anti-exercise fatigue and isoliquiritigenin, which is used in drug combinations, antidote, metabolic diseases, etc.

Inactive Publication Date: 2017-09-05
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Isoliquiritigenin has the pharmacological activity of eliminating free radicals and anti-oxidation, but the research on isoliquiritigenin for anti-exercise fatigue has not been reported yet

Method used

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  • Application of isoliquiritigenin to preparation of drugs used for improving or treating exercise-induced fatigue, and pharmaceutical composition
  • Application of isoliquiritigenin to preparation of drugs used for improving or treating exercise-induced fatigue, and pharmaceutical composition
  • Application of isoliquiritigenin to preparation of drugs used for improving or treating exercise-induced fatigue, and pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Research on the effect of isoliquiritigenin on exercise-induced fatigue in swimming training mice

[0018] 1. Experimental animals:

[0019] Experimental mice were purchased from the Experimental Animal Center of Ningxia Medical University, male, four weeks old, body weight (22 ± 2g), SPF grade, animal production license number: SYXK (Ning). Feeding conditions include standard feed, tap water, room temperature maintained at (24±2)°C, humidity 50-60%, and daily light and dark times of 12 hours each. Before the preparation of the experiment, the animals were placed in the experimental environment for 3 days to adapt.

[0020] 2. Experimental drugs and instruments

[0021] Medicines: Isoliquiritigenin (purity 98%, purchased from Aladdin Reagent Company), trichloroacetic acid (AR, McLean Reagent Company), glucose (AR, Aladdin Reagent Company), sodium carboxymethylcellulose (AR, Mike Lean’s Reagent Company), Lin Reagent Company), Anthrone (AR, Aladdin Reagent C...

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Abstract

The invention provides application of isoliquiritigenin to preparation of drugs used for improving or treating exercise-induced fatigue, and a pharmaceutical composition. The pharmaceutical composition is a preparation prepared from isoliquiritigenin used as a main active component and a pharmaceutically acceptable adjuvant, wherein the adjuvant may be any acceptable excipient, and a weight ratio of isoliquiritigenin to the adjuvant is 10: 90 to 90: 10. According to the invention, an animal model is constructed in the process of research of isoliquiritigenin, and the variation levels of hepatic glycogen, blood lactate and blood urea nitrogen in mouse samples are detected; and isoliquiritigenin is proved to have prevention effect on exercise-induced fatigue, and the pharmaceutical composition capable of preventing exercise-induced fatigue is prepared.

Description

technical field [0001] The invention belongs to the technical field of application of isoliquiritigenin, in particular to the application and pharmaceutical composition of isoliquiritigenin as a medicine for improving or treating exercise-induced fatigue. Background technique [0002] Exercise-induced fatigue is an eternal theme in the research of sports medicine and exercise physiology. Regarding the formation mechanism of exercise-induced fatigue, various hypotheses have been put forward, such as the theory of energy material depletion, the theory of free radical damage, the theory of neurotransmitters, the theory of lactic acid accumulation and the theory of Ca 2+ Steady-state anomaly theory, etc. [0003] The theory of exhaustion of energy substances proposes that energy substances include various glycogen, ATP, creatine phosphate, etc. During short-term high-intensity exercise, the body will use a large amount of energy substances such as glycogen to decompose to provi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61P3/00A61P39/00
CPCA61K31/12
Inventor 王志忠褚慧敏罗生霞戈胡蓉黄青马沛沛魏世杰
Owner NINGXIA MEDICAL UNIV
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