Method for inhibiting proliferation of gastric cancer and drug thereof

A gastric cancer and drug technology, applied in drug combinations, antineoplastic drugs, digestive system, etc., can solve problems such as poor prognosis, lack of early diagnosis, and unoptimistic prospects for patients with advanced gastric cancer

Inactive Publication Date: 2017-09-22
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although improvements in diagnosis and treatment have resulted in relatively good long-term survival expectations for early gastric cancer, the outlook for patients with advanced gastric cancer remains grim
The poor prognosis is often due to the lack of biomarkers for early diagnosis and effective treatments

Method used

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  • Method for inhibiting proliferation of gastric cancer and drug thereof
  • Method for inhibiting proliferation of gastric cancer and drug thereof
  • Method for inhibiting proliferation of gastric cancer and drug thereof

Examples

Experimental program
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Embodiment Construction

[0021] Referring to the accompanying drawings, the method for inhibiting the proliferation of gastric cancer disclosed by the present invention reduces the copy number of mitochondrial mtDNA and the expression of DNA polymerase gamma in gastric cancer cells, enhances oxidative stress and triggers the disorder of cellular energy metabolism, so as to inhibit the proliferation of gastric cancer cells.

[0022] The invention also provides the following technical scheme: a drug for inhibiting the proliferation of gastric cancer, the drug being curcumin.

[0023] 1. Curcumin inhibits the growth of gastric cancer cells and promotes ROS-mediated apoptosis

[0024] To investigate the role of curcumin in regulating the growth of gastric cancer cells, we determined the concentration of curcumin (0-40 µg / ml) that affected cell viability and found that its effect on reducing cell viability was dose-dependent ( Figure 1A and B). In addition, curcumin treatment (10 µg / ml) reduced cell proli...

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Abstract

The invention relates to a method for inhibiting the proliferation of gastric cancer and drugs thereof. The method comprises the steps that through the reduction of the copy number of gastric cancer cell mitochondria mtDNA and the expression of DNA polymerase gamma, oxidative stress is enhanced and further metabolism disorders of cell energy are triggered in order to inhibit the proliferation of gastric cancer cells. The technical scheme has the technical effects of being effective in inhibiting the proliferation of gastric cancer.

Description

technical field [0001] The invention relates to a method and medicine for inhibiting gastric cancer proliferation. Background technique [0002] Gastric cancer is the fourth most common tumor and the second most common cause of cancer death in the world. Although improvements in diagnosis and treatment have resulted in relatively good long-term survival expectations for early gastric cancer, the outlook for patients with advanced gastric cancer is still not optimistic. The poor prognosis is often due to the lack of biomarkers for early diagnosis and effective treatments. Therefore, we are very eager to identify a new and more effective therapeutic drug to overcome this difficulty. [0003] Of the thousands of natural compounds initially tested for their anticancer potential, only about 40 promising drugs have made it to clinical trials. Curcumin, a diketone compound derived from turmeric tubers and commonly known as "Haldi" in India, is one of these drugs currently in cli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61P35/00A61P1/00
Inventor 陈通克王丽花蓝林华
Owner WENZHOU MEDICAL UNIV
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