Bone-cartilage defect integrated repair bioceramic scaffold and preparation method and use thereof

A bioceramic and cartilage technology, applied in ceramic molding machines, prostheses, manufacturing tools, etc., can solve the problems that articular cartilage defects cannot be repaired, tricalcium phosphate does not have the function of cartilage repair, etc., and achieve excellent biological activity and excellent mechanical properties. Intensity, effect of increasing alkaline phosphatase activity

Active Publication Date: 2020-07-14
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, tricalcium phosphate does not have the function of cartilage repair and cannot be used for the repair of articular cartilage defects

Method used

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  • Bone-cartilage defect integrated repair bioceramic scaffold and preparation method and use thereof
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  • Bone-cartilage defect integrated repair bioceramic scaffold and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Dissolve diammonium hydrogen phosphate in deionized water (pH is 8, concentration is 0.5mol / L), manganese chloride tetrahydrate and calcium nitrate are respectively mixed and dissolved in deionized water according to the molar mass of (2.5, 5, 10): 100 In deionized water, and the resulting mixed solution of manganese chloride tetrahydrate and calcium nitrate (pH is 4.5, Mn ion concentration is respectively 0.012mol / L, 0.024mol / L, 0.05mol / L, Ca ion concentration is 0.5mol / L ) into the diammonium hydrogen phosphate solution, adjust the pH value to 7.49-7.53 with 10% ammonia water, fully stir at room temperature for 24 hours, filter with suction, and wash three times with deionized water and three times with absolute ethanol, 100 ℃ drying for 12 hours, and sintering at 800 ℃ for 3 hours to prepare Mn-TCP bioceramic powders with different Mn contents;

[0078] Mix the obtained series of Mn-TCP ceramic powder (with a particle size of 50 μm): sodium alginate (with a particle ...

Embodiment 2

[0081] Dissolve diammonium hydrogen phosphate in deionized water (pH is 7.5, concentration is 0.4mol / L), manganese chloride tetrahydrate and calcium nitrate are mixed according to the molar mass of 4:100, dissolved in deionized water, and the obtained Manganese chloride tetrahydrate and calcium nitrate mixed solution (pH is 4, Mn ion concentration is 0.02mol / L, Ca ion concentration is 0.4mol / L) is added dropwise in diammonium hydrogen phosphate solution, adjust pH with 10% ammonia water The value is 7.53-7.62, fully stirred at room temperature for 24 hours, suction filtered, washed three times with deionized water, washed three times with absolute ethanol, dried at 100°C for 12 hours, and sintered at 700°C for 4 hours to obtain Mn- TCP bioceramic powder;

[0082] The obtained Mn-TCP ceramic powder (with a particle size of 75 μm): sodium alginate (with a particle size of 20 μm): F127 (with a concentration of 10%) was mixed with a mass ratio of 1:0.05:0.6, and a printing program...

Embodiment 3

[0085] Dissolve diammonium hydrogen phosphate in deionized water (pH is 8.5, concentration is 0.6mol / L), manganese chloride tetrahydrate and calcium nitrate are mixed according to the molar mass of 7.5:100, dissolved in deionized water, and the obtained Manganese chloride tetrahydrate and calcium nitrate mixed solution (pH is 5, Mn ion concentration is 0.0375mol / L, Ca ion concentration is 0.6mol / L) is added dropwise in diammonium hydrogen phosphate solution, adjust pH with 10% ammonia water The value is 7.6-7.7, fully stirred at room temperature for 24 hours, suction filtered, washed three times with deionized water, washed three times with absolute ethanol, dried at 100°C for 12 hours, and sintered at 900°C for 5 hours to obtain Mn- TCP bioceramic powder;

[0086] The obtained Mn-TCP ceramic powder (with a particle size of 75 μm): sodium alginate (with a particle size of 50 μm): F127 (with a concentration of 15%) was mixed with a mass ratio of 1:0.15:1.0, and a printing progr...

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Abstract

The invention relates to a bioceramic scaffold for integrated repair of bone-cartilage defects and a preparation method and application thereof; the bioceramic scaffold comprises a three-dimensional tricalcium phosphate ceramic scaffold and manganese ions distributed evenly in the same. The bioceramic scaffold of the invention provides bidirectional biological function of cartilage and subchondral bone integrated repair for arthritic bone-cartilage complex defects.

Description

technical field [0001] The invention relates to a novel bifunctional bioceramic support and its preparation method and application, belonging to the field of biomaterials. Background technique [0002] Bone-cartilage complex tissue, also known as osteochondral complex, includes articular cartilage and subchondral bone [1] , cartilage and subchondral bone are a whole, they are interdependent and inseparable [2] . There are many factors that cause articular cartilage defects, such as trauma, disease, congenital deformity, aging and improper exercise, etc. Due to the physiological characteristics of cartilage tissue, the ability of articular cartilage to repair itself is extremely poor, so cartilage damage often causes joint dysfunction and Subchondral bone involved [3-7] . While repairing cartilage defects, we must attach great importance to the relationship between subchondral bone and articular cartilage, and strive to achieve simultaneous and integrated repair of the os...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/04A61L27/50A61L27/54B28B1/00C04B35/447C04B35/622
CPCA61L27/047A61L27/12A61L27/50A61L27/54A61L2300/412A61L2430/02A61L2430/06B28B1/001C04B35/447C04B35/622C04B2235/3262C04B2235/449C04B2235/5436C04B2235/6026
Inventor 吴成铁邓翠君常江
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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