Preparation method of a clinically sculptable magnesium silicate/polyamino acid composite material

A polyamino acid and composite material technology, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems of lack of biological activity, inability to effectively promote the proliferation of osteoblasts, poor osteogenicity, etc., and achieve good biological activity, The effect of promoting the proliferation of bone marrow mesenchymal stem cells and facilitating clinical shaping

Active Publication Date: 2021-09-24
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although there have been a few reports on polymer materials used as bone repair materials in recent years, most of them lack biological activity, cannot effectively promote the proliferation of osteoblasts, and have poor osteogenesis.

Method used

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  • Preparation method of a clinically sculptable magnesium silicate/polyamino acid composite material
  • Preparation method of a clinically sculptable magnesium silicate/polyamino acid composite material
  • Preparation method of a clinically sculptable magnesium silicate/polyamino acid composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The preparation of embodiment 1 amino acid copolymer

[0047] Weigh 95g of 6-aminocaproic acid, 24g of 4-aminobutyric acid, 5g of proline, and 3g of lysine, put them into a 250ml three-neck flask, add 60mL of deionized water at the same time, and add 0.1mL of catalyst phosphoric acid, oil Heat the bath and keep stirring to 160°C for 1 hour of dehydration, raise the temperature to 200°C for 1 hour, and continue to raise the temperature to 210°C for 3 hours. In order to avoid oxidation, nitrogen protection was used throughout the experiment, and the resulting product was amino acid copolymer, named PAA.

Embodiment 2

[0048] The preparation of embodiment 2 amino acid copolymers

[0049] Weigh 95g of 6-aminocaproic acid, 24g of 4-aminobutyric acid, 5g of proline, and 3g of lysine, put them into a 250ml three-neck flask, add 60mL of deionized water at the same time, and add 0.1mL of catalyst phosphoric acid, oil Heat the bath and keep stirring to dehydrate at 160°C for 1 hour, raise the temperature to 200°C for 1 hour, and continue to raise the temperature to 220°C for 4 hours. In order to avoid oxidation, nitrogen protection was used throughout the experiment, and the resulting product was amino acid copolymer.

Embodiment 3

[0050] Embodiment 3 Preparation of amino acid copolymer

[0051] Weigh 94g of 6-aminocaproic acid, 24g of 4-aminobutyric acid, 5g of proline, 3g of lysine, and 1.5g of glutamic acid, put them into a 250ml three-necked flask, add 60mL of deionized water at the same time, and add Catalyst Phosphoric acid 0.1mL, heated in an oil bath and continued to stir to dehydrate at 160°C for 1h, raise the temperature to 200°C for 1h, and continue to raise the temperature to 220°C for 3h. In order to avoid oxidation, nitrogen protection was used throughout the experiment, and the resulting product was amino acid copolymer.

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Abstract

The invention provides a method for preparing a clinically sculptable magnesium silicate / polyamino acid composite material. The method uses the clinically sculptable polyamino acid and magnesium silicate as raw materials for reaction; The polyamino acid for clinical shaping is obtained by polymerizing any 3 or 4 amino acids of 6-aminocaproic acid and 4-aminobutyric acid, proline, lysine, and glutamic acid as monomers. The composite material prepared by the above method can be arbitrarily shaped at a relatively low temperature, which is beneficial for doctors to operate according to the specific shape of the bone defect during the operation; the composite material has good biological activity, is conducive to bone formation in vivo, and can It effectively promotes the proliferation of bone marrow mesenchymal stem cells, and has a good application prospect in the preparation of bone repair materials for repairing irregular bone defects and promoting bone defect regeneration. The preparation method of the invention is simple, the raw materials are easy to obtain, and the cost is low, which is suitable for industrialized expanded production.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a clinically plastic magnesium silicate / polyamino acid composite material, a preparation method thereof, and an application in preparing bone repair materials. Background technique [0002] Bone injury repair has always been one of the common problems in orthopedics. Every year in my country, more than 50 million people suffer from bone injuries or bone defects caused by trauma, tumors, congenital diseases and other reasons. For large areas of damage, bone tissue is difficult to repair itself, and bone substitute materials are needed for filling and repairing. Therefore, the research and development of new bone defect repair materials is of great clinical significance. [0003] The shape of human bone defects is often irregular, such as skull, jaw, vertebrae and other defects such as limb bones, etc., which requires bone repair materials to have the characteristi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/44A61L27/50A61L27/56A61L27/58
CPCA61L27/446A61L27/50A61L27/56A61L27/58A61L2430/02C08L77/04
Inventor 李鸿魏杰李漱阳何浩生李林郑衡彭海涛杜艳杨爱萍吕国玉
Owner SICHUAN UNIV
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