37 results about "Radial cartilage" patented technology

The invention is directed to a process for making a tissue repair implant having a porous sponge-like structure to repair bone, cartilage, or soft tissue defects by producing a connective tissue homogenate from one or more connective tissues; mixing the connective tissue homogenate with a carrier solution to produce a connective tissue carrier; optionally mixing one or more natural or synthetic bone fragements with said connective tissue carrier to produce a tissue repair mixture; freezing or freeze-drying the tissue repair mixture to produce a porous sponge-like structure and create a three-dimensional framework to entrap the natural or synthetic bone fragments, treating the frozen or freeze-dried porous sponge-like structure with one or more treatment solutions to produce a stabilized porous sponge-like structure. A crudely fragmented connective tissue from one or more connective tissues is optionally mixed with the tissue repair mixture before freezing or freeze-drying. The tissue repair implant having a porous sponge-like structure is optionally combined with one or more bioactive supplements or one or more agents that have bioactive supplement binding site(s) to increase the affinity of growth factors, differentiation factor, cytokines, or anti-inflammatory agents to the tissue repair implant. The invention is further directed toward applying such tissue repair implant for tissue repair.

A portable surgical workstation for implant formation comprising a base with a central planar section. The central planar section has a plurality of tracks and a throughgoing slot with a recessed stepped surrounding surface formed on a bottom surface of the central planar section. A vise assembly mounted to the base comprises a fixed jaw member secured to the base, a traveling jaw member moveably mounted to the base and a fixed drive housing mounted to the base. The traveling jaw member has a plurality of rail members adapted to be slidably mounted in the central planar section tracks. The fixed drive housing has a threaded longitudinal bore which receives a threaded drive shaft, one end of the drive shaft being secured in the traveling jaw member to transport the traveling jaw member.

The invention relates to a kind of laminated gradient composite scaffold material based on the bionic structure and its preparation method. The said material has three or more layers of porous structure, comprising of hyaluronic acid, PLGA, PLA, collagen II and nano-hydroxyapatite (nano-HA) , beta- tricalcium phosphate ( beta-TCP). The upper layer is made by collagen II / hyaluronic acid or PLGA and PLA imitating the cartilage layer. With the counterfeit the calcified cartilage layer in the middle, it is one layer or multi- sublayer, made by nano-HA or beta-TCP with collagen II / hyaluronic acid or PLGA and PLA; the bottom is made of nano-HA or beta-TCP with collagen II or PLGA and PLA. From top to bottom, the content of inorganic material increases in its layers, about 0 to 60 mass percent of layers. The aperture of the scaffold material is 50 to 450 micron, with 70 to 93 percent porosity. The scaffold material made by this invention has an adjustable degradation rate, good mechanical and biocompatible properties, can adapt to culture with cartilage bone cells and compound with growth factor and small molecular or peptides, it can be used to repair cartilage simultaneously.

The invention relates to a method of producing an elastin-reduced cartilage scaffold containing channels and / or lacunae, the method comprising the steps of providing an elastic cartilage sample and reducing elastin from said cartilage sample to produce said channels and / or lacunae. The invention further relates to an elastin-reduced cartilage scaffold. Said elastin-reduced cartilage scaffold can be used in a method of implantation in vivo, for repairment of cartilage, repairment of osteochondral defects and repairment of bone defects.

The present invention provides a scaffold for artificial cornea and its preparation method, which includes decalcified and decellularized cancellous bone matrix sheet → soaking and sticking nano-scale cartilage, umbilical cord and other ECM cell extracellular matrix inside and outside the scaffold → composite autologous Mesenchymal stem cells (bone marrow, fat and other cells), cultured and placed in the interlayer, front surface, conjunctiva or submucosal of the cornea, used to replace bone, cartilage or tooth bone in artificial corneal surgery, as a scaffold or reinforcement of artificial cornea Material. The scaffold for artificial cornea according to the present invention has a microenvironment that is conducive to the growth of cells in vivo and in vitro through adsorption induction, can promote the differentiation of mesenchymal stem cells into cartilage-like and osteogenic tissues in vivo, facilitates the fixation of artificial cornea, and improves the artificial cornea. occupancy rate.

The invention provides a 3D biomimetic biological scaffold containing stem cell exosomes and its application. The biomimetic scaffold uses methacrylic anhydride gelatin, oxidized hyaluronic acid and dopamine-modified hyaluronic acid as the main material, and adds cartilage decellularization Matrix (DCM) or bone decellularized matrix (DBM) mimics the microenvironment of cartilage or osteochondral bone and adds mesenchymal stem cell exosomes (Exos) as a bioink, using 3D printing bioinks to construct containing Hydrogel‑DCM‑Exos and Hydrogel‑DBM‑Exos, a composite scaffold that mimics the bioactivity of cartilage and subchondral bone while promoting healing of articular cartilage and subarticular bone.

The invention provides a bionic osteochondral complex and a preparation method thereof. The bionic osteochondral complex includes a cartilage layer, a barrier layer and a subchondral bone layer, and the two sides of the barrier layer are respectively connected to the subchondral bone layer and the subchondral bone layer. The cartilage layer is connected. The bionic osteochondral complex provided by the present invention can be implanted in human cartilage damage sites, and the cartilage, subchondral barrier layer and subchondral bone can be repaired in an integrated way, and the formation can not only induce the migration of endogenous cells but also play a barrier function biomimetic osteochondral prosthesis.

The present invention proposes a method for preparing an osteochondral integrated scaffold based on 3DP and laser cladding composite technology, using 3DP technology to prepare the subchondral bone layer of the scaffold, laser cladding technology to prepare the cartilage layer, and 3DP and laser cladding technology to prepare the calcified layer of the scaffold , while realizing the precise preparation of osteochondral integrated scaffolds, it meets the requirements of biocompatibility of osteochondral scaffolds, meets the requirements of connection strength and mechanical strength between each layer of scaffolds, and prepares bionic integrated bone that meets structural gradients and mechanical gradients. Cartilage scaffolding.