26 results about "Radial cartilage" patented technology

The present invention relates to a device and method for obtaining an augmented patient-specific bone / cartilage model of a target anatomical structure of a patient.

A system may be provided for osteochondral defect repair, and may include a guide with a first leg, a second leg, a third leg, a fourth leg, and a guide feature. The first leg, the second leg, the third leg, and the fourth leg may each have a distal tip. The distal tips of the first leg, the second leg, the third leg, and the fourth leg may lie in a plane. The guide feature may be oriented to define a working axis, perpendicular to the plane, along which a cutter is movable to remove bone and cartilage from a first bone.

There is disclosed a defect sizer tool for selection of an appropriately sized pre-cut core for a cryopreserved osteochondral allograft (COCA) transplantation procedure. In an embodiment, the tool includes an elongated connector that provides a handle portion. A ring measurement guide at one end, with a given diameter, and alignable with a cartilage defect to provide an estimated measurement of a diameter. There is disclosed an instrument kit with a pin, a pin guide, and a reamer configured to slidingly receive the pin, blades at one end, and a rotational drive connector at the other end. In an embodiment, a method for a COCA transplantation procedure includes providing an instrument kit, using the pin guide to place the pin in the subchondral bone, and operating the reamer to score surrounding cartilage prior to the reamer bit portion reaming the subchondral bone to the desired depth. Other embodiments are also disclosed.

A system for osteochondral defect repair may include a guide configured to determine a topography of a section of a cartilage surface of a first bone. The guide may have a body defining a longitudinal axis, a plurality of legs extending from the body, and a locking mechanism that is movable, without application of force along the longitudinal axis, between an unlocked configuration, in which each of the legs is slidable, relative to the body, along the longitudinal axis to contact the cartilage surface to capture the topography, and a locked configuration, in which the locking mechanism engages the legs to prevent sliding of the legs, relative to the body, along the longitudinal axis.

The application discloses a kind of bionic bone / cartilage double-layer composite scaffold material and its preparation method and application.The bionic bone / cartilage double-layer composite scaffold material of the application is composed of upper cartilage repair hydrogel layer and lower bone repair scaffold layer.The main feature of the application is that by radial freezing, the chitosan-chitin whisker liquid crystal composite hydrogel micron radial channel with diameter gradient change is constructed in the lower scaffold, which can promote the transport of nutrients, cell recruitment, migration and adhesion;At the same time, the drug-loaded liquid crystal hydrogel constructed in the longitudinal large channel of the scaffold and the upper cartilage repair layer can realize the sustained release of active drugs, so as to further regulate stem cell osteogenesis / cartilage differentiation and promote the generation of blood vessels, and is expected to have good application prospect as biomedical materials such as bone / cartilage tissue repair materials.

A system for harvesting bone material from a bone may include a rotary cutter defining a rotary cutter longitudinal axis extending between a rotary cutter proximal end and a rotary cutter distal end. The rotary cutter may have a drive shaft configured to receive input torque, and an osteochondral cutter configured to cut the tissue and receive the tissue material in response to rotation of the osteochondral cutter under pressure against the tissue. The system may further include a bone port defining a bone port longitudinal axis extending between a bone port proximal end and a bone port distal end. The bone port may have a bone port cannulation sized to closely fit over the osteochondral cutter. At least one of the bone port proximal end and the bone port distal end may be securable to the tissue. A stratiform tissue graft may be delivered through the bone port.

The invention relates to the technical field of biomedical materials, in particular to a double-network hydrogel material for bionic cartilage and subchondral bone and a preparation method of the double-network hydrogel material. According to the double-network hydrogel material for the bionic cartilage and the subchondral bone, polyvinyl alcohol is adopted as a first network skeleton, and a high-toughness hydrogel structure is formed through a circulating freezing and thawing method; sulfobetaine methacrylate and a calcium chloride solution are introduced as a second network cross-linking system, so that the material is endowed with excellent hydrophilic lubrication performance; furthermore, liposome microspheres are compounded to form a self-renewal liposome boundary layer, so that the friction coefficient is remarkably reduced; the material has high strength, high toughness, low friction, self-lubrication and biocompatibility, is suitable for precise repair and functional reconstruction of osteochondral defects such as femoral head necrosis and the like, and has a wide clinical application prospect.

The application relates to the technical field of femoral head necrosis treatment, in particular to a bionic artificial balloon type half hip joint, which comprises a sleeve, a femoral neck, a fixing screw and a femoral neck limiting nut, the sleeve is fixed on a femur through the fixing screw, the femoral neck is slidingly connected in the sleeve, a balloon is fixed on the outer periphery of the top section of the femoral neck, the inside of the femoral neck is hollow, and a side hole is arranged at the top end of the femoral neck and communicates with the balloon, and the femoral neck limiting nut is used for being fixed in the sleeve to position the femoral neck. The balloon type femoral head is compared with the metal and ceramic femoral heads, the balloon type femoral head is more matched with the shape of the acetabulum in terms of shape, the elastic modulus of the balloon type femoral head is equivalent to that of the bone cartilage of the acetabulum, the balloon type femoral head is beneficial to cartilage nutrition, and the wear of the bone cartilage of the acetabulum is small; the balloon is in a shriveled state when no filler is filled in the balloon, the balloon can be placed in the femur along the sleeve, the joint capsule and the medullary cavity do not need to be opened, the trauma is small, the risk of subsequent infection and dislocation is small, meanwhile, the prosthesis wear can be replaced through the sleeve, and the replacement is convenient and fast and can be completed under local anesthesia.

The invention belongs to the field of tissue regeneration materials, and relates to a 3D printing triboelectric material and application thereof in bone and cartilage defect repair. The material can be used as 3D printing ink for manufacturing a triboelectric bracket. The scaffold is prepared by taking biodegradable PGS as a matrix, PEDOT: PSS as a conductive component and sodium chloride as a pore-forming agent through combination of 3D printing and a salt particle pore-forming method, and has a multi-stage porous structure and excellent triboelectric properties. The wire diameter, interlayer spacing and micropore distribution of the stent are accurately regulated and controlled through the 3D printing technology, so that in-situ self-energized electrical stimulation of the stent is realized in an in-vivo dynamic mechanical environment; the scaffold can promote the BMSCs to differentiate into cartilage cells, construct tissue engineering cartilage and accelerate the process of ossification in cartilage, finally realizes efficient repair of bone and cartilage defects, is excellent in biocompatibility and biodegradable, does not need an external power supply device, and has a wide clinical transformation prospect in the field of bone and cartilage defect repair.

A method of repairing a chondral or osteochondral defect using an implant composition made of a plurality of demineralized bone fibers formed into a contiguous shape having a peg portion and a sheet portion to facilitate cartilage repair.

The invention relates to the fabrication of biocompatible scaffolds, in particular materials capable of inducing hypoxia in order to enhance cartilage regeneration by creating and maintaining an optimal microenvironment. Compositions and methods for their preparation and use thereof in the treatment of chondral and osteochondral diseases or lesions are described.

The invention discloses an intelligent matching and operation planning system for osteochondral defect repair, and relates to the technical field of orthopedic implant design, and the system comprises an image acquisition and preprocessing module which is used for obtaining high-resolution nuclear magnetic resonance image data of both knee joints of a patient; and the three-dimensional modeling module is used for carrying out segmentation and three-dimensional reconstruction on the nuclear magnetic resonance image data, generating a knee joint three-dimensional entity model comprising the proximal tibia, the proximal fibula, the distal femur and the surface cartilage of the proximal tibia, the proximal fibula, the distal femur and the surface cartilage of the proximal tibia, the proximal fibula and the distal femur. The bearing curved surface of the prosthesis can accurately reproduce the self-healthy articular surface curvature of a patient, so that good anatomical matching and biomechanical compatibility are formed with an opposite-side joint after the prosthesis is implanted. Meanwhile, the handle structure is intelligently generated according to the three-dimensional shape of the defect area, and initial stable fixation of the prosthesis in the bone is facilitated.

The invention belongs to the field of tissue regeneration materials, and relates to a 3D printing triboelectric material and application thereof in bone and cartilage defect repair. The material can be used as 3D printing ink for manufacturing a triboelectric bracket. The scaffold is prepared by taking biodegradable PGS as a matrix, PEDOT: PSS as a conductive component and sodium chloride as a pore-forming agent through combination of 3D printing and a salt particle pore-forming method, and has a multi-stage porous structure and excellent triboelectric properties. The wire diameter, interlayer spacing and micropore distribution of the stent are accurately regulated and controlled through the 3D printing technology, so that in-situ self-energized electrical stimulation of the stent is realized in an in-vivo dynamic mechanical environment; the scaffold can promote the BMSCs to differentiate into cartilage cells, construct tissue engineering cartilage and accelerate the process of ossification in cartilage, finally realizes efficient repair of bone and cartilage defects, is excellent in biocompatibility and biodegradable, does not need an external power supply device, and has a wide clinical transformation prospect in the field of bone and cartilage defect repair.

Cutting elements may include points, tips, cutting portions and / or shafts of various geometries depending on requirements of the intended use. Tip geometries described may be used for cutting burrs, k-wires and / or drill bits in many types of applications. In particular, the tip geometries described may be used in medical applications. For example, tip geometries as described herein may be used for drilling bones, cartilage, and similar structures during surgery. Tip geometry may influence cutting ability. Use of the tip geometries described may allow the cutting element to be positioned at varying angles relative to the surface to be cut. In some instances, a tip geometry for a cutting element may be selected such that it reduces and / or inhibits movement of the cutting element during use and / or allows for a predetermined angle of entry into a surface to be cut. Using the designs described herein may reduce and / or inhibit damage, heat, and / or trauma to materials that are to be cut, for example, tissues such as bone and / or cartilage.

The invention relates to an osteochondral syringe type adsorption pen. The osteochondral syringe type adsorption pen comprises an adsorption sleeve with an inner cavity, an adsorption assembly connected with one end of the adsorption sleeve and an operating rod. The adsorption assembly is provided with adsorption holes communicated with the inner cavity, and the front end face of the adsorption assembly is an arc-shaped adsorption face. Two opposite ends of the operating rod are respectively marked as a first end extending into the inner cavity and a second end located outside the inner cavity and provided with a pressing part, and the first end is provided with a piston head matched with the inner wall of the inner cavity; an elastic device is arranged between the operating rod and the adsorption sleeve, and the operating rod overcomes the elastic force of the elastic device when bearing external force and drives the piston head to move towards one side of the adsorption assembly. And when the external force is removed, the piston head is driven to move towards one side far away from the adsorption assembly under the action of the restoring force of the elastic device. Non-contact operation in the whole process of graft obtaining and transplantation is achieved, edge damage is avoided, and structural integrity is guaranteed. Meanwhile, the obtaining and transplanting integrated function is achieved, surgical instrument replacement is reduced, and the pollution risk is reduced.

There is disclosed a defect sizer tool for selection of an appropriately sized pre-cut core for a cryopreserved osteochondral allograft (COCA) transplantation procedure. In an embodiment, the tool includes an elongated connector that provides a handle portion. A ring measurement guide at one end, with a given diameter, and alignable with a cartilage defect to provide an estimated measurement of a diameter. There is disclosed an instrument kit with a pin, a pin guide, and a reamer configured to slidingly receive the pin, blades at one end, and a rotational drive connector at the other end. In an embodiment, a method for a COCA transplantation procedure includes providing an instrument kit, using the pin guide to place the pin in the subchondral bone, and operating the reamer to score surrounding cartilage prior to the reamer bit portion reaming the subchondral bone to the desired depth. Other embodiments are also disclosed.

The application provides a kind of ankle talus cartilage segmentation and thickness measurement method, it is related to image processing technical field, the ankle talus nuclear magnetic image of the present application is collected, constructs ankle talus cartilage segmentation standard data set to be used to network training. Method first to ankle talus nuclear magnetic image is standardized, and the data set of being labeled is used to train segmentation model. Then, the trained model is applied to new nuclear magnetic image data, and the segmentation result of talus cartilage is obtained by model prediction. Finally, based on the segmentation result, the average thickness of talus cartilage is calculated using mathematical algorithms and image processing techniques. The method provided by the present application can provide accurate diagnostic basis for clinicians, help orthopedic surgeons predict the amount of cartilage that needs to be repaired, avoid over-treatment, significantly improve the accuracy and efficiency of ankle talus cartilage segmentation, and reduce the time and error of manual operation. The method has wide application prospects in talus cartilage injury assessment and treatment effect monitoring.

The present invention provides a method for producing an artificial bone-cartilage complex, the method comprising: (i) a step for inducing differentiation of pluripotent stem cells to obtain a precartilage cell mass; (ii) a step for seeding and culturing the precartilage cell mass obtained in the step (i) on the surface of an artificial bone having communication holes; and (iii) a step for recovering an artificial bone-cartilage complex in which a cartilage layer is formed on the surface of the artificial bone. Also provided is an artificial bone-cartilage complex produced by said method.

The invention discloses a double-layer piezoelectric hydrogel scaffold for realizing articular cartilage injury repair through ultrasonic regulation, the piezoelectric hydrogel scaffold comprises a scaffold upper layer for cartilage repair and a scaffold lower layer for subchondral bone repair, the upper layer and the lower layer both comprise a colloid component and a piezoelectric component, wherein the mass percent concentration of piezoelectric components in the upper layer of the piezoelectric hydrogel stent is lower than that of piezoelectric components in the lower layer of the piezoelectric hydrogel stent. The mechanical property and gradient piezoelectric property of the double-layer piezoelectric hydrogel scaffold are matched with articular bone cartilage tissue regeneration, and cartilage-bone synergistic regeneration can be accurately regulated and controlled. The novel bionic hydrogel scaffold can significantly improve articular cartilage injury, and has a wide clinical application prospect.

A paste graft construct for repairing cartilage defects includes a prepared bone and cartilage plug that is ground into a paste and combined with a hyaluronic acid-based hydrogel. The combined paste and hydrogel may also be mixed with mesenchymal stem cells (MSCs) and / or birth tissue such as Wharton's jelly. The bone and cartilage plug may be prepared by smashing or cutting.

The invention discloses a preparation method and an application of a double-layer GelMA-AlgMA functional hydrogel scaffold loaded with a growth factor. Comprising the following steps: preparing a GelMA hydrogel precursor solution of composite KGN; an AlgMA hydrogel precursor solution of the composite BMP-2 is prepared; and 3D printing. The preparation method has the beneficial effects that the GelMA compounded with the KGN and the AlgMA compounded with the BMP-2 are combined into the double-layer stent, the KGN promotes cartilage formation, the BMP-2 promotes bone formation, growth factors are released in a targeted manner, and specific repair is performed aiming at different tissue layers of an osteochondral interface.

The invention belongs to the technical field of bone tissue engineering and regenerative medicine, and particularly discloses a piezoelectric-photo-thermal dual-mode composite stent for articular cartilage repair and a preparation method of the piezoelectric-photo-thermal dual-mode composite stent. The preparation method comprises the three steps of MXene preparation, electrostatic spinning and paper folding structure construction, poly-L-lactic acid and MXene nanosheets are compounded to prepare a fiber membrane, and then the fiber membrane is subjected to hot pressing through a corrugated mold to form the three-dimensional stent with the periodic creased structure. The scaffold has piezoelectric property and photo-thermal property at the same time, promotes cartilage differentiation through the piezoelectric effect, inhibits subchondral bone angiogenesis through the photo-thermal effect, maintains a low-oxygen microenvironment, realizes integral repair of cartilage-subchondral bone functional units, can be used for treatment of cartilage defects, osteochondral defects and osteoarthritis, and has a wide application prospect. The problem that the cartilage steady state is damaged due to the fact that a traditional piezoelectric material promotes bone vascularization is solved.

The invention relates to the technical field of auxiliary diagnosis, and discloses a talus health monitoring and recognition system fusing image features and biomechanical parameters, and the system comprises an image processing module which is used for extracting a talus cartilage geometric mask, reconstructing a boundary signal, and outputting a pure biochemical voxel set; the grid construction module is used for generating an individualized calculation grid by using non-rigid registration and transmitting an anatomical partition label; the constitutive mapping module is used for constructing a non-uniform dynamic viscoelastic stiffness matrix based on the biochemical numerical value and the partition strain rate; the finite element solving module is used for calculating a stress distribution field under the physiological load; and the evaluation output module is used for determining a local yield strength threshold value according to the biochemical numerical value and calculating a local tissue vulnerability index by comparing the local yield strength threshold value with a stress field. According to the method, deep coupling analysis of cartilage biochemical degeneration and mechanical response is realized, a recessive high-risk area caused by tissue degeneration can be accurately identified, and a reliable quantitative basis is provided for talus health monitoring.

The invention provides an osteochondral repair scaffold based on an extremely small curved surface, and belongs to the field of tissue engineering repair materials, the scaffold comprises a cartilage repair layer and a subchondral bone repair layer which are made of the same material, and the cartilage repair layer and the subchondral bone repair layer are both of an extremely small curved surface bionic porous structure. And the bionic porous structures of the cartilage repair layer and the subchondral bone repair layer are in continuous smooth transition at the junction of the two layers. Furthermore, the pore diameter and the pore wall thickness of the subchondral bone repair layer are gradually changed in a gradient mode in the longitudinal axis direction of the stent. The problems of interface layering, incompatibility of mechanical properties and pore structures and the like of a multi-layer bracket are solved.

Systems, methods, and compositions directed to the engineered incorporation of a tidemark-mimetic into a 3D printed osteochondral (OC)-mimetic hydrogel scaffold configured to recapitulate a mineralized barrier that restricts transport of calcifying ions into the articular (hyaline) cartilage layer, and / or an engineered cement line-mimetic configured to prevent cellular migration from the subchondral bone layer into the cartilage layers.

The application relates to an in-situ osteochondral regeneration and repair support and a preparation method thereof. The in-situ osteochondral regeneration and repair support prepared by the method comprises a cartilage layer, a connecting layer and a subchondral bone layer. The porosity of the cartilage layer is not less than 85%, the Young's modulus is 6-13 KPa, and the pore size is 130-140 mu m. The porosity of the connecting layer is not less than 95%, the Young's modulus is 4-19 KPa, and the pore size is 50-120 mu m. The porosity of the subchondral bone layer is not less than 95%, the Young's modulus is 4-19 KPa, and the pore size is 300-400 mu m. The in-situ osteochondral regeneration and repair support prepared by the method has good biocompatibility, is beneficial to the adhesion, migration and proliferation of cartilage cells and bone marrow mesenchymal stem cells, cannot cause immune rejection, provides a better support environment for the repair after osteochondral implantation, and does not affect the migration of cells through experiments. The in-situ osteochondral regeneration and repair support has a good repair effect on the osteochondral defects of rats through animal experiments.