58 results about "Radial cartilage" patented technology

The invention belongs to the technical field of biomedical materials, and particularly relates to a gradient bionic wood-based collagen bone-cartilage repair scaffold and a preparation method and application thereof.The scaffold comprises a surface layer, a middle layer and a bottom layer, the surface layer is composed of collagen, the middle layer is composed of collagen and nano-hydroxyapatite, and the bottom layer is composed of collagen and nano-hydroxyapatite; the bottom layer is composed of wood, collagen and nano-hydroxyapatite, the scaffold is obtained by stacking the surface layer, the middle layer and the bottom layer and then conducting freeze-drying, the structure of the scaffold is similar to that of natural osteochondral cartilage, the surface layer is of a porous structure communicated with one another, and the bottom layer is of a directionally-arranged pore channel structure; the main composition of a natural bone cartilage tissue can be highly simulated, and the gradient is presented; the bone marrow mesenchymal stem cell prepared by the method has the advantages of high mechanical performance, gradient enhancement from the surface layer to the bottom layer, excellent biocompatibility and biological activity, capability of remarkably promoting cell proliferation and gradient differentiation of bone marrow mesenchymal stem cells, and application to osteochondral tissue regeneration and clinical treatment of osteoarthritis.

The invention discloses a method for preparing a personalized biphasic condylar scaffold, which comprises the following steps: collecting data to separate a mandibular digital model; selecting data on the opposite side of a lesion area in the mandibular digital model, and mirror-symmetric mapping the data to the lesion area to obtain a condylar head and neck prosthesis model; designing and printing a bone phase scaffold according to the condylar tissue structure morphology; preparing a cartilage phase scaffold; spraying a dense layer on the surface of the bone phase scaffold head, connecting the cartilage phase scaffold with the dense layer by a "dissolution-adhesion" process to form a dense layer bone-cartilage composite scaffold, thereby constructing a condylar biphasic composite scaffold; and designing a retention handle on the condylar biphasic composite scaffold to construct a personalized biphasic bionic condylar scaffold, which not only solves the problem that autologous bone transplantation for temporomandibular joint reconstruction cannot restore the condylar morphology and there are complications in the bone donor area, but also solves the problem that the mechanical properties of the materials and the degradation cycle of the existing prosthesis do not meet clinical needs.

The present invention relates to a device and method for obtaining an augmented patient-specific bone / cartilage model of a target anatomical structure of a patient.

The periosteum detacher comprises a handle, a telescopic assembly and a tool bit part, the two ends of the telescopic assembly are connected with the handle and the tool bit part respectively, and the telescopic assembly is used for adjusting the distance between the handle and the tool bit part; the tool bit part is in bent connection with the telescopic assembly, and the included angle formed by the tool bit part and the telescopic assembly is larger than 80 degrees; the outer edge of the cutter head part extends towards the direction of the handle to form a curved surface, and a cutting edge is arranged on the outer edge of the cutter head part. According to the utility model, the distance between the handle and the cutter head part can be adjusted through the telescopic assembly according to requirements, so that the operation of the stripper is facilitated; the included angle formed by the knife head part and the telescopic assembly is larger than 80 degrees, so that the operation convenience of an operator can be improved, the tissue stripping difficulty in the costal cartilage taking process can be reduced, wounds are reduced to the minimum, rapid recovery of a patient is promoted, and the pain of the patient is relieved.

A system may be provided for osteochondral defect repair, and may include a guide with a first leg, a second leg, a third leg, a fourth leg, and a guide feature. The first leg, the second leg, the third leg, and the fourth leg may each have a distal tip. The distal tips of the first leg, the second leg, the third leg, and the fourth leg may lie in a plane. The guide feature may be oriented to define a working axis, perpendicular to the plane, along which a cutter is movable to remove bone and cartilage from a first bone.

There is disclosed a defect sizer tool for selection of an appropriately sized pre-cut core for a cryopreserved osteochondral allograft (COCA) transplantation procedure. In an embodiment, the tool includes an elongated connector that provides a handle portion. A ring measurement guide at one end, with a given diameter, and alignable with a cartilage defect to provide an estimated measurement of a diameter. There is disclosed an instrument kit with a pin, a pin guide, and a reamer configured to slidingly receive the pin, blades at one end, and a rotational drive connector at the other end. In an embodiment, a method for a COCA transplantation procedure includes providing an instrument kit, using the pin guide to place the pin in the subchondral bone, and operating the reamer to score surrounding cartilage prior to the reamer bit portion reaming the subchondral bone to the desired depth. Other embodiments are also disclosed.

A system for osteochondral defect repair may include a guide configured to determine a topography of a section of a cartilage surface of a first bone. The guide may have a body defining a longitudinal axis, a plurality of legs extending from the body, and a locking mechanism that is movable, without application of force along the longitudinal axis, between an unlocked configuration, in which each of the legs is slidable, relative to the body, along the longitudinal axis to contact the cartilage surface to capture the topography, and a locked configuration, in which the locking mechanism engages the legs to prevent sliding of the legs, relative to the body, along the longitudinal axis.

The present invention provides an integrated design and manufacturing technology for a bone cartilage biomimetic gradient scaffold. The invention includes a functionally graded integrated bone cartilage biomimetic gradient scaffold, a transition structure for achieving graded transition between hard bone and cartilage tissue, and a biomimetic cartilage formation and post-processing method. The integrated bone cartilage biomimetic gradient scaffold is a porous interconnected ceramic structure that can be manufactured through integrated additive manufacturing. The transition structure is a special structure for firmly connecting hard bone and cartilage. The biomimetic cartilage formation and post-processing method involves performing special treatment on the 3D-printed bone scaffold to form biomimetic cartilage, thereby improving the strength of the cartilage layer and preventing cartilage damage caused by joint friction. The bone cartilage biomimetic scaffold structure proposed by the present invention has effective functional grading to mimic natural bone cartilage tissue, which is beneficial for preventing stress shielding and can be manufactured in one piece using 3D additive manufacturing technology.

The application discloses a kind of bionic bone / cartilage double-layer composite scaffold material and its preparation method and application.The bionic bone / cartilage double-layer composite scaffold material of the application is composed of upper cartilage repair hydrogel layer and lower bone repair scaffold layer.The main feature of the application is that by radial freezing, the chitosan-chitin whisker liquid crystal composite hydrogel micron radial channel with diameter gradient change is constructed in the lower scaffold, which can promote the transport of nutrients, cell recruitment, migration and adhesion;At the same time, the drug-loaded liquid crystal hydrogel constructed in the longitudinal large channel of the scaffold and the upper cartilage repair layer can realize the sustained release of active drugs, so as to further regulate stem cell osteogenesis / cartilage differentiation and promote the generation of blood vessels, and is expected to have good application prospect as biomedical materials such as bone / cartilage tissue repair materials.

A system for harvesting bone material from a bone may include a rotary cutter defining a rotary cutter longitudinal axis extending between a rotary cutter proximal end and a rotary cutter distal end. The rotary cutter may have a drive shaft configured to receive input torque, and an osteochondral cutter configured to cut the tissue and receive the tissue material in response to rotation of the osteochondral cutter under pressure against the tissue. The system may further include a bone port defining a bone port longitudinal axis extending between a bone port proximal end and a bone port distal end. The bone port may have a bone port cannulation sized to closely fit over the osteochondral cutter. At least one of the bone port proximal end and the bone port distal end may be securable to the tissue. A stratiform tissue graft may be delivered through the bone port.

The invention relates to the technical field of medicine, in particular to a minimally invasive construction method of a pig bone load-bearing and non-load-bearing area cartilage injury animal model, which comprises the following steps of: performing modeling based on pig CT (Computed Tomography) data; setting boundary conditions and applying a load; determining a stress area and a non-stress area according to a finite element analysis result; minimally-invasively exposing the medial condyle of the femur and performing osteochondral injury modeling; and noninvasively exposing the thighbone tackle cartilage and carrying out osteochondral injury modeling. According to the method, the stress area and the non-stress area of the pig knee joint are accurately defined through the finite element analysis technology. A minimally invasive surgery approach is creatively developed, full exposure of cartilages in different stress areas of the knee joint is achieved, and an important tool is provided for deep repair and reconstruction of cartilage injuries.

The invention relates to an in-situ lubrication 3D printing Janus bone cartilage repair scaffold and a preparation method thereof.The scaffold is prepared through 3D printing and comprises a subchondral bone layer and a cartilage layer, the subchondral bone layer is prepared from GelMA and NAGA loaded nHA, and bone healing is promoted; the cartilage layer is provided with zwitterionic monomers, and in-situ lubrication is achieved. In-situ lubrication can be realized through lubrication modification of the cartilage layer scaffold structure, and bone healing is promoted by loading hydroxyapatite on the subchondral bone layer scaffold.

The invention relates to the technical field of biomedical materials, in particular to a double-network hydrogel material for bionic cartilage and subchondral bone and a preparation method of the double-network hydrogel material. According to the double-network hydrogel material for the bionic cartilage and the subchondral bone, polyvinyl alcohol is adopted as a first network skeleton, and a high-toughness hydrogel structure is formed through a circulating freezing and thawing method; sulfobetaine methacrylate and a calcium chloride solution are introduced as a second network cross-linking system, so that the material is endowed with excellent hydrophilic lubrication performance; furthermore, liposome microspheres are compounded to form a self-renewal liposome boundary layer, so that the friction coefficient is remarkably reduced; the material has high strength, high toughness, low friction, self-lubrication and biocompatibility, is suitable for precise repair and functional reconstruction of osteochondral defects such as femoral head necrosis and the like, and has a wide clinical application prospect.

The application relates to the technical field of femoral head necrosis treatment, in particular to a bionic artificial balloon type half hip joint, which comprises a sleeve, a femoral neck, a fixing screw and a femoral neck limiting nut, the sleeve is fixed on a femur through the fixing screw, the femoral neck is slidingly connected in the sleeve, a balloon is fixed on the outer periphery of the top section of the femoral neck, the inside of the femoral neck is hollow, and a side hole is arranged at the top end of the femoral neck and communicates with the balloon, and the femoral neck limiting nut is used for being fixed in the sleeve to position the femoral neck. The balloon type femoral head is compared with the metal and ceramic femoral heads, the balloon type femoral head is more matched with the shape of the acetabulum in terms of shape, the elastic modulus of the balloon type femoral head is equivalent to that of the bone cartilage of the acetabulum, the balloon type femoral head is beneficial to cartilage nutrition, and the wear of the bone cartilage of the acetabulum is small; the balloon is in a shriveled state when no filler is filled in the balloon, the balloon can be placed in the femur along the sleeve, the joint capsule and the medullary cavity do not need to be opened, the trauma is small, the risk of subsequent infection and dislocation is small, meanwhile, the prosthesis wear can be replaced through the sleeve, and the replacement is convenient and fast and can be completed under local anesthesia.

The present invention relates to a fully automatic spatial registration system based on multimodal information fusion, comprising: a preoperative planning module for fusing preoperative knee joint MRI and CT images to reconstruct a "bone + cartilage" combined navigation model; an intraoperative point cloud extraction module for scanning and automatically extracting intraoperative knee joint lesion cartilage surface point cloud data; and a spatial registration module for aligning the cartilage surface point cloud reconstructed in the preoperative CT image space with the cartilage surface point cloud data scanned intraoperatively, thereby achieving navigation registration between the intraoperative patient space and the preoperative image space. The present invention's point cloud-based registration method can achieve similar accuracy registration without selecting anatomical points, greatly reducing the degree of dependence on the doctor. This technology greatly assists doctors, allowing them to focus more on the surgery itself.

The invention relates to an osteochondral scaffold with biological energy activity and a preparation method of the osteochondral scaffold, and belongs to the technical field of biological materials and tissue engineering. The method comprises the following steps: carrying out first chemical reaction on an intermediate of tricarboxylic acid cycle and trihydric alcohol to obtain a bio-energy material prepolymer; performing a second chemical reaction on the bio-energy material prepolymer and a cross-linking agent, and adding an osteogenesis promoting agent into a system of the second chemical reaction to obtain composite slurry; regulating and controlling the weight of the osteogenesis promoting agents in the composite slurry to obtain three biological energy material inks containing the osteogenesis promoting agents with different weights; carrying out gradient type 3D printing on the three kinds of biological energy material ink containing the osteogenesis promoting agents with different weights so as to respectively simulate a cartilage layer, a transition layer and a subchondral bone layer in the articular cartilage, and carrying out a third chemical reaction after 3D printing, so as to obtain the target osteochondral scaffold. The osteochondral scaffold provided by the invention has biological energy activity, and realizes regeneration of transparent cartilage and reconstruction of an osteochondral complex interface.

The invention belongs to the field of tissue regeneration materials, and relates to a 3D printing triboelectric material and application thereof in bone and cartilage defect repair. The material can be used as 3D printing ink for manufacturing a triboelectric bracket. The scaffold is prepared by taking biodegradable PGS as a matrix, PEDOT: PSS as a conductive component and sodium chloride as a pore-forming agent through combination of 3D printing and a salt particle pore-forming method, and has a multi-stage porous structure and excellent triboelectric properties. The wire diameter, interlayer spacing and micropore distribution of the stent are accurately regulated and controlled through the 3D printing technology, so that in-situ self-energized electrical stimulation of the stent is realized in an in-vivo dynamic mechanical environment; the scaffold can promote the BMSCs to differentiate into cartilage cells, construct tissue engineering cartilage and accelerate the process of ossification in cartilage, finally realizes efficient repair of bone and cartilage defects, is excellent in biocompatibility and biodegradable, does not need an external power supply device, and has a wide clinical transformation prospect in the field of bone and cartilage defect repair.

A method of repairing a chondral or osteochondral defect using an implant composition made of a plurality of demineralized bone fibers formed into a contiguous shape having a peg portion and a sheet portion to facilitate cartilage repair.

The invention relates to the fabrication of biocompatible scaffolds, in particular materials capable of inducing hypoxia in order to enhance cartilage regeneration by creating and maintaining an optimal microenvironment. Compositions and methods for their preparation and use thereof in the treatment of chondral and osteochondral diseases or lesions are described.

The invention discloses an intelligent matching and operation planning system for osteochondral defect repair, and relates to the technical field of orthopedic implant design, and the system comprises an image acquisition and preprocessing module which is used for obtaining high-resolution nuclear magnetic resonance image data of both knee joints of a patient; and the three-dimensional modeling module is used for carrying out segmentation and three-dimensional reconstruction on the nuclear magnetic resonance image data, generating a knee joint three-dimensional entity model comprising the proximal tibia, the proximal fibula, the distal femur and the surface cartilage of the proximal tibia, the proximal fibula, the distal femur and the surface cartilage of the proximal tibia, the proximal fibula and the distal femur. The bearing curved surface of the prosthesis can accurately reproduce the self-healthy articular surface curvature of a patient, so that good anatomical matching and biomechanical compatibility are formed with an opposite-side joint after the prosthesis is implanted. Meanwhile, the handle structure is intelligently generated according to the three-dimensional shape of the defect area, and initial stable fixation of the prosthesis in the bone is facilitated.

The invention belongs to the field of tissue regeneration materials, and relates to a 3D printing triboelectric material and application thereof in bone and cartilage defect repair. The material can be used as 3D printing ink for manufacturing a triboelectric bracket. The scaffold is prepared by taking biodegradable PGS as a matrix, PEDOT: PSS as a conductive component and sodium chloride as a pore-forming agent through combination of 3D printing and a salt particle pore-forming method, and has a multi-stage porous structure and excellent triboelectric properties. The wire diameter, interlayer spacing and micropore distribution of the stent are accurately regulated and controlled through the 3D printing technology, so that in-situ self-energized electrical stimulation of the stent is realized in an in-vivo dynamic mechanical environment; the scaffold can promote the BMSCs to differentiate into cartilage cells, construct tissue engineering cartilage and accelerate the process of ossification in cartilage, finally realizes efficient repair of bone and cartilage defects, is excellent in biocompatibility and biodegradable, does not need an external power supply device, and has a wide clinical transformation prospect in the field of bone and cartilage defect repair.

Provided is a method of stimulating regeneration of cartilage in an area of diseased cartilage in a layer of cartilage in a first bone of a joint. The method includes forming a first recess in the first bone at the area of diseased cartilage, and positioning a first spherical implant within the first recess, where the first spherical implant is dimensioned to be smaller than the first recess so that the first spherical implant is capable of moving in two dimensions within the first recess resulting in shear forces between the first spherical implant and the cartilage and stimulates formation of fibrous tissue which subsequently transforms into cartilage.

Cutting elements may include points, tips, cutting portions and / or shafts of various geometries depending on requirements of the intended use. Tip geometries described may be used for cutting burrs, k-wires and / or drill bits in many types of applications. In particular, the tip geometries described may be used in medical applications. For example, tip geometries as described herein may be used for drilling bones, cartilage, and similar structures during surgery. Tip geometry may influence cutting ability. Use of the tip geometries described may allow the cutting element to be positioned at varying angles relative to the surface to be cut. In some instances, a tip geometry for a cutting element may be selected such that it reduces and / or inhibits movement of the cutting element during use and / or allows for a predetermined angle of entry into a surface to be cut. Using the designs described herein may reduce and / or inhibit damage, heat, and / or trauma to materials that are to be cut, for example, tissues such as bone and / or cartilage.

The invention relates to an osteochondral syringe type adsorption pen. The osteochondral syringe type adsorption pen comprises an adsorption sleeve with an inner cavity, an adsorption assembly connected with one end of the adsorption sleeve and an operating rod. The adsorption assembly is provided with adsorption holes communicated with the inner cavity, and the front end face of the adsorption assembly is an arc-shaped adsorption face. Two opposite ends of the operating rod are respectively marked as a first end extending into the inner cavity and a second end located outside the inner cavity and provided with a pressing part, and the first end is provided with a piston head matched with the inner wall of the inner cavity; an elastic device is arranged between the operating rod and the adsorption sleeve, and the operating rod overcomes the elastic force of the elastic device when bearing external force and drives the piston head to move towards one side of the adsorption assembly. And when the external force is removed, the piston head is driven to move towards one side far away from the adsorption assembly under the action of the restoring force of the elastic device. Non-contact operation in the whole process of graft obtaining and transplantation is achieved, edge damage is avoided, and structural integrity is guaranteed. Meanwhile, the obtaining and transplanting integrated function is achieved, surgical instrument replacement is reduced, and the pollution risk is reduced.

There is disclosed a defect sizer tool for selection of an appropriately sized pre-cut core for a cryopreserved osteochondral allograft (COCA) transplantation procedure. In an embodiment, the tool includes an elongated connector that provides a handle portion. A ring measurement guide at one end, with a given diameter, and alignable with a cartilage defect to provide an estimated measurement of a diameter. There is disclosed an instrument kit with a pin, a pin guide, and a reamer configured to slidingly receive the pin, blades at one end, and a rotational drive connector at the other end. In an embodiment, a method for a COCA transplantation procedure includes providing an instrument kit, using the pin guide to place the pin in the subchondral bone, and operating the reamer to score surrounding cartilage prior to the reamer bit portion reaming the subchondral bone to the desired depth. Other embodiments are also disclosed.

The application provides a kind of ankle talus cartilage segmentation and thickness measurement method, it is related to image processing technical field, the ankle talus nuclear magnetic image of the present application is collected, constructs ankle talus cartilage segmentation standard data set to be used to network training. Method first to ankle talus nuclear magnetic image is standardized, and the data set of being labeled is used to train segmentation model. Then, the trained model is applied to new nuclear magnetic image data, and the segmentation result of talus cartilage is obtained by model prediction. Finally, based on the segmentation result, the average thickness of talus cartilage is calculated using mathematical algorithms and image processing techniques. The method provided by the present application can provide accurate diagnostic basis for clinicians, help orthopedic surgeons predict the amount of cartilage that needs to be repaired, avoid over-treatment, significantly improve the accuracy and efficiency of ankle talus cartilage segmentation, and reduce the time and error of manual operation. The method has wide application prospects in talus cartilage injury assessment and treatment effect monitoring.

A device and method for applying compressive load to the irregular complete surface of bone cartilage, relating to the fields of biomechanics and mechanics. It comprises a cylindrical loading cylinder, a cross-shaped loading slider, a base, a customized mold, a U-shaped clamp, a positioning splint, and a connector. The bottom of the cylindrical loading cylinder is provided with a base that matches it, and the inner wall of the cylindrical loading cylinder is provided with a rectangular sliding guide rail, which matches the cross-shaped loading slider. The lower end of the cross-shaped loading slider is provided with a U-shaped clamp, and bolts and rectangular guide rails are installed on one side of the U-shaped clamp, and the bolts and rectangular guide rails are connected to the positioning splint. It is conducive to achieving full contact between the surface of the bone cartilage and the surface of the customized mold, so as to achieve the effect of simulating the interaction between the joint surfaces of animals; it is conducive to simulating the contact and force conditions of the surface of the articular cartilage when it is subjected to a compressive load in vivo, and plays a positive role in promoting in vitro cartilage experiments.

The present invention relates to a surgical kit of parts comprising the following instruments: • a guide wire (a1) having a drill tip (a2); • a cartilage punch (b1) with an axial hole (b3) with a circular geometry in the radial direction over the whole length such that the guide wire (a1) can be slid through the axial hole (b3) of the cartilage punch (b1), wherein the hollow cylinder (b2) forms at one end (b4) a circular cutting edge (b5) with an external diameter Db,external and an inwardly tapered circular cutting wall (b6); and • a bone milling drill (c1) with an axial hole (c3) having a circular geometry in the radial direction over the whole length, wherein one end (c4) of the hollow cylinder (c2) has the form of an end milling cutter (c5) with an external diameter Dc,external, with the proviso that the guide wire (a1) can be slid through the axial hole (c3) of the bone milling drill (c1) and with the further proviso that the external diameter Db,external of the circular cutting edge (b5) of the cartilage punch (b1) equals the external diameter Dc,external of the end milling cutter (c5) of the bone milling drill (c1). The invention further pertains to a method of repairing an (osteo)chondral defect of the knee in a subject with the surgical kit.

The present invention provides a method for producing an artificial bone-cartilage complex, the method comprising: (i) a step for inducing differentiation of pluripotent stem cells to obtain a precartilage cell mass; (ii) a step for seeding and culturing the precartilage cell mass obtained in the step (i) on the surface of an artificial bone having communication holes; and (iii) a step for recovering an artificial bone-cartilage complex in which a cartilage layer is formed on the surface of the artificial bone. Also provided is an artificial bone-cartilage complex produced by said method.

The invention relates to a cartilage injury identification system based on multi-modal deep learning, and relates to the field of cartilage injury identification, and the system comprises a deep learning mechanism which is used for executing deep learning operation on a feedforward neural network to obtain an intelligent injury identification model; and the intelligent identification mechanism is used for identifying the patella cartilage injury level of the current patient according to the multi-modal data of the current patient by adopting an intelligent injury identification model. The invention also relates to a cartilage injury identification method based on multi-modal deep learning. According to the invention, for the technical problem that the patella cartilage injury level of each patient lacks a targeted multi-modal intelligent identification model, customized visual information of various nuclear magnetic images and knee front images and multiple patella cartilage associated data of the current patient can be introduced as multi-modal data; an intelligent injury identification model which is customized and designed for a current patient and is subjected to deep learning is introduced as an artificial intelligence model, so that the technical problem is solved.