Implantation tool and protocol for optimized solid substrates promoting cell and tissue growth

A technology of solid matrix and tissue growth, applied in the direction of joint implants, joint implants, prostheses, etc., can solve the problem of lack of ideal means and materials for restoring tissue function and promoting the reconstruction of its shape

Pending Publication Date: 2020-10-16
CARTIHEAL 2009
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] So far, there is still a lack of ideal means and materials to restore the tissue function of such tissues and promote the reconstruction of their morphology

Method used

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  • Implantation tool and protocol for optimized solid substrates promoting cell and tissue growth
  • Implantation tool and protocol for optimized solid substrates promoting cell and tissue growth
  • Implantation tool and protocol for optimized solid substrates promoting cell and tissue growth

Examples

Experimental program
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Embodiment 1

[0363] Optimized approach for solid matrix implantation

[0364] A variety of tools and implants are contemplated for implanting in osteochondral defects and are considered equivalents for use in the methods / procedures of the present invention.

[0365] Figures 1A-1S A general procedure for preparing defect site 1-05 is described. In this particular procedure, osteochondral defects in the condyles are treated. As a first step, the area in need of osteochondral repair is exposed by conventional means. Before implanting the osteochondral inductive implant, prepare the implantation site. First, and as described in WO 2014 / 072982, fully incorporated herein by reference, an implant alignment tool 1-10 is placed on the desired implant site, which tool facilitates rod-like structures (eg, k-wire 1 -20) Insertion therethrough for insertion into the tissue repair site at an angle / perpendicular to the tissue surface of substantially 90 degrees. Figure 1B depicts the ability to at...

Embodiment 2

[0390] Improved solid substrate incorporation as a function of coral-based solid substrate positioning according to methods according to the invention

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Abstract

This invention provides methods for optimal implantation of a solid substrate for promoting cell or tissue growth or restored function in an osteochondral, bone or cartilage tissue in a subject in need thereof. The methods include selecting and preparing a solid substrate for promoting cell or tissue growth or restored function for implantation, which solid substrate has a length and width or thatpromotes a tight fit within the boundaries of the implantation site and is further characterized by a height sufficient such that when a first terminus of said solid substrate is implanted within a bone in a site for implantation, a second terminus of said solid substrate is at a height at least 2 mm less than an articular cartilage layer surface or is proximal to a tide mark region in said implantation site and optionally applying a biocompatible polymer layer to an apical surface of said implant, which layer does not exceed the articular cartilage layer surface in height. Tools for implementation of optimal positioning are described including a unique tool (5-120) for trimming cartilage at the implantation site.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Patent Application No. 62 / 612,735, filed January 2, 2018, and U.S. Provisional Patent Application No. 62 / 783,221, filed December 21, 2018, both of which are incorporated herein by reference in their entirety . Background technique [0003] Tissue growth, regeneration, and repair are often necessary to restore tissue function and remodel tissue morphology, for example, as a result of trauma exposure, neoplasia, abnormal tissue growth, aging, and others. [0004] Articular cartilage is a highly specialized tissue that coats the surface of long bones to allow nearly frictionless movement under large loads. In healthy bones, this joint function allows the bone to change its relative angular relationship to the joint, as in the hip and knee joints. This function of the joint occurs painlessly and with little additional effort due to the properties of synovial fluid in...

Claims

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Application Information

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IPC IPC(8): A61F2/30A61B17/16A61B17/17A61F2/46
CPCA61F2/30756A61B17/1604A61B17/1615A61B17/1635A61B17/1659A61B17/17A61B17/1764A61F2/4618A61B2017/0046A61F2002/30759A61F2002/30214A61F2002/30224A61F2002/30253A61F2002/30593A61F2002/30617A61F2002/30761
Inventor N·阿尔特舒勒
Owner CARTIHEAL 2009
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