A method for preparing osteochondral integrated scaffold based on 3dp and laser cladding composite technology

A composite process and laser cladding technology, which is applied in prosthesis, medical science, joint implants, etc., can solve the problems of lack of transition layer and difficulty in preventing implanted cell migration, and achieve good repeatability, compact structure, and high precision. high effect

Active Publication Date: 2021-02-02
西安博恩生物科技有限公司
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Problems solved by technology

This method has good biocompatibility and is easy to operate, but there is no transition layer between the cartilage tissue and the hard bone tissue prepared by this method, and a structural mutation occurs at the joint surface of the cartilage and hard bone, which makes it difficult to prevent the implanted cells from developing in the osteogenic state. Migrate between cells and chondrogenic scaffolds, affecting the proliferation and differentiation of cells in specific areas in their respective microenvironments

Method used

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Embodiment Construction

[0042] Embodiments of the present invention are described in detail below, and the embodiments are exemplary and intended to explain the present invention, but should not be construed as limiting the present invention.

[0043] The present invention proposes a method for preparing an osteochondral integrated scaffold based on 3DP and laser cladding composite technology, that is, using 3DP technology to prepare the subchondral bone layer of the scaffold, laser cladding technology to prepare the cartilage layer, and 3DP and laser cladding technology to prepare the scaffold The calcified layer, while realizing the precise preparation of the osteochondral integrated scaffold, meets the biocompatibility requirements of the osteochondral scaffold, meets the requirements of the connection strength and mechanical strength between the tissues of each layer of the scaffold, and prepares a bionic integration that meets the structural gradient and mechanical gradient. Osteochondral Scaffol...

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Abstract

The present invention proposes a method for preparing an osteochondral integrated scaffold based on 3DP and laser cladding composite technology, using 3DP technology to prepare the subchondral bone layer of the scaffold, laser cladding technology to prepare the cartilage layer, and 3DP and laser cladding technology to prepare the calcified layer of the scaffold , while realizing the precise preparation of osteochondral integrated scaffolds, it meets the requirements of biocompatibility of osteochondral scaffolds, meets the requirements of connection strength and mechanical strength between each layer of scaffolds, and prepares bionic integrated bone that meets structural gradients and mechanical gradients. Cartilage scaffolding.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterial preparation, relates to a three-dimensional osteochondral scaffold and a preparation method thereof, in particular to a method for preparing an osteochondral integrated scaffold based on a composite process of 3DP and laser cladding. Background technique [0002] Articular cartilage defects caused by trauma, sports injuries, various arthritic diseases and other factors are very common in clinical practice. Osteochondral damage is often irreversible, often causing osteoarthritis, and even life-threatening. Osteochondral composite tissue defects in joints have become one of the main causes of physical disability. At present, articular cartilage lesions are mainly treated by implanting substitutes, which mainly include autologous or allogeneic tissues, artificial cartilage, etc. Among them, there are problems such as limited sources of autologous or allogeneic tissues and difficulty in s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/30A61L27/12A61L27/02A61L27/18A61L27/50
Inventor 汪焰恩白宗耀魏庆华张娟郭莹王艳梅
Owner 西安博恩生物科技有限公司
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